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ZY39

Name: ZY39
Brand: TargetMol
SKU: T212928
Price: 279 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T212928 Copy Product Info

Purity: 99.96%

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ZY39 is a selective casein protease P (ClpP) agonist that inhibits the growth of multidrug-resistant strains by selectively activating Staphylococcus aureus ClpP (SaClpP). ZY39 also promotes the enzymatic hydrolysis of human ClpP (HsClpP) in vitro. ZY39 inhibits the growth of multidrug-resistant strains in a mouse peritonitis model of Staphylococcus aureus infection. ZY39 can be used in research related to Staphylococcus aureus infections.

Cas No. 2999673-51-5

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Pack Size	Price	USA Stock	Global Stock
1 mg	$279	-	In Stock
5 mg	$683	-	In Stock
10 mg	$1,090	-	In Stock
25 mg	$2,190	-	In Stock
50 mg	$3,550	-	In Stock
1 mL x 10 mM (in DMSO)	$879	-	In Stock

For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)

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For research use only—not for human use. No sales to individuals. Use as intended only.

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Purity:99.96%

Appearance:Solid

Color:White

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COA LCMS HNMR

Product Introduction

Bioactivity

Description	ZY39 is a selective casein protease P (ClpP) agonist that inhibits the growth of multidrug-resistant strains by selectively activating Staphylococcus aureus ClpP (SaClpP). ZY39 also promotes the enzymatic hydrolysis of human ClpP (HsClpP) in vitro. ZY39 inhibits the growth of multidrug-resistant strains in a mouse peritonitis model of Staphylococcus aureus infection. ZY39 can be used in research related to Staphylococcus aureus infections.
In vitro	Methods: The MIC of ZY39 against Newman, USA300, and multidrug-resistant MRSA clinical isolates (XJ009, XJ025, XJ049, etc.) was determined; ΔclpP mutant and rescue strains were constructed to verify target dependency. Results: The MIC of ZY39 against all tested Staphylococcus aureus strains ranged from 0.03 to 0.13 μg/mL, with potent inhibition of MRSA; the antimicrobial activity was entirely dependent on SaClpP. [1]
In vivo	Methods: An acute infection model in zebrafish was established by intraperitoneal injection of USA300. Thirty minutes after infection, ZY39 (0.5, 5, 25 mg/kg) was administered intraperitoneally, and survival rates were monitored for 5 days. Results: A dose of 0.5 mg/kg ZY39 effectively improved the survival rate of zebrafish. [1] Methods: ICR mice were administered a lethal dose of USA300 or XJ049 via intraperitoneal injection. One hour after infection, ZY39 (25, 50 mg/kg), (R)-ZG197, vancomycin, and benzylpenicillin were administered intraperitoneally, and survival rates and organ bacterial loads were monitored. Results: ZY39 (25, 50 mg/kg) increased the survival rate of USA300-infected mice to 89%–100% and significantly reduced bacterial loads in the heart, liver, spleen, lungs, kidneys, and peritoneal fluid; there were no significant changes in body weight during the treatment period, indicating good safety.[1]

Chemical Properties

Molecular Weight	548.60
Formula	C₂₈H₃₅F₃N₄O₄
Cas No.	2999673-51-5
Smiles	C(NCCCC(F)(F)F)(=O)N1[C@@]2(N([C@@]([C@H](CC)C)(C(=O)N(CC=3C4=C(C(OC)=CC3)C=CC=C4)C2)[H])C(=O)CC1)[H]
Relative Density.	no data available

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 80 mg/mL (145.83 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.8228 mL	9.1141 mL	18.2282 mL	91.1411 mL
5 mM	0.3646 mL	1.8228 mL	3.6456 mL	18.2282 mL
10 mM	0.1823 mL	0.9114 mL	1.8228 mL	9.1141 mL
20 mM	0.0911 mL	0.4557 mL	0.9114 mL	4.5571 mL
50 mM	0.0365 mL	0.1823 mL	0.3646 mL	1.8228 mL
100 mM	0.0182 mL	0.0911 mL	0.1823 mL	0.9114 mL

Note : The dilution table applies only to solid products. For liquid products, please calculate the stock solution based on the stated concentration and/or density.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Keywords

ZY39

Related Tags: ZY39 chemical structure | ZY39 in vivo | ZY39 in vitro | ZY39 formula | ZY39 molecular weight