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LY 2389575 hydrochloride

🥰Excellent
Catalog No. T22204Cas No. 885104-09-6

LY2389575 hydrochloride is an mGlu3 negative allosteric modulator (NAM) that is selective and non-competitive, with an IC50 value of 190 nM. LY2389575 hydrochloride induces an increase in the level of Mrc1, which amplifies the toxicity of β-amyloid (Aβ), and can be used to study Alzheimer's disease. It can be used to study Alzheimer's disease.

LY 2389575 hydrochloride

LY 2389575 hydrochloride

🥰Excellent
Purity: 99.45%
Catalog No. T22204Cas No. 885104-09-6
LY2389575 hydrochloride is an mGlu3 negative allosteric modulator (NAM) that is selective and non-competitive, with an IC50 value of 190 nM. LY2389575 hydrochloride induces an increase in the level of Mrc1, which amplifies the toxicity of β-amyloid (Aβ), and can be used to study Alzheimer's disease. It can be used to study Alzheimer's disease.
Pack SizePriceAvailabilityQuantity
1 mg$51In Stock
5 mg$122In Stock
10 mg$197In Stock
25 mg$428In Stock
50 mg$639In Stock
100 mg$890In Stock
500 mg$1,830In Stock
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Purity:99.45%
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COA HPLC HNMR

Product Introduction

Bioactivity
Description
LY2389575 hydrochloride is an mGlu3 negative allosteric modulator (NAM) that is selective and non-competitive, with an IC50 value of 190 nM. LY2389575 hydrochloride induces an increase in the level of Mrc1, which amplifies the toxicity of β-amyloid (Aβ), and can be used to study Alzheimer's disease. It can be used to study Alzheimer's disease.
Targets&IC50
mGluR3:190 nM
In vitro
LY2389575 hydrochloride (5 μM; 1 h) induces an increase in Mrc1 levels in microglial cells.[2]
Chemical Properties
Molecular Weight438.58
FormulaC15H16BrCl3N4
Cas No.885104-09-6
SmilesN(CC1=C(Cl)C=C(Cl)C=C1)[C@@H]2CN(CC2)C=3N=CC(Br)=CN3.Cl
Relative Density.no data available
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
DMSO: 90.0 mg/mL (205.2 mM), Sonication and heating to 60℃ are recommended.
Methanol: 7.5 mg/mL (17.1 mM), Sonication and heating to 60℃ are recommended.
Solution Preparation Table
Methanol/DMSO
1mg5mg10mg50mg
1 mM2.2801 mL11.4004 mL22.8009 mL114.0043 mL
5 mM0.4560 mL2.2801 mL4.5602 mL22.8009 mL
10 mM0.2280 mL1.1400 mL2.2801 mL11.4004 mL
DMSO
1mg5mg10mg50mg
20 mM0.1140 mL0.5700 mL1.1400 mL5.7002 mL
50 mM0.0456 mL0.2280 mL0.4560 mL2.2801 mL
100 mM0.0228 mL0.1140 mL0.2280 mL1.1400 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.
1 Enter information below:
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2 Enter the in vivo formulation:
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Keywords

βAmyloidβ AmyloidmGluRLY-2389575 HydrochlorideLY2389575 HydrochlorideLY 2389575 hydrochlorideLY 2389575 HydrochlorideBetaAmyloidBeta AmyloidbAmyloidb AmyloidAβ
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