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Anticancer agent 210
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Catalog No. T209642
Anticanceragent 210 (Compound 7a) is a derivative of Gefitinib. It inhibits the proliferation, migration, and colony formation of cancer cells and induces apoptosis in H1299 cells.
Anticancer agent 210
Anticancer agent 210
😃Good
Catalog No. T209642
Anticanceragent 210 (Compound 7a) is a derivative of Gefitinib. It inhibits the proliferation, migration, and colony formation of cancer cells and induces apoptosis in H1299 cells.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 10 mg | Inquiry | Backorder | Backorder | |
| 50 mg | Inquiry | Backorder | Backorder |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Product Introduction
Bioactivity
Chemical Properties
| Description | Anticanceragent 210 (Compound 7a) is a derivative of Gefitinib. It inhibits the proliferation, migration, and colony formation of cancer cells and induces apoptosis in H1299 cells. |
| In vitro | Anticancer agent 210 inhibits the proliferation of lung cancer cells NCI-H1299, A549, and NCI-H1437 with IC50 values of 3.94, 3.16, and 1.84 μM, respectively, when used at concentrations of 0-32 μM for 48 hours. This compound exhibits mild cytotoxicity towards normal liver cells L02, with an IC50 of 18.87 μM and maintaining a cell survival rate of over 60% at concentrations of 2-16 μM for 48 hours. Additionally, Anticancer agent 210 induces apoptosis in non-small cell lung cancer (NSCLC) cells via the Bcl-2/caspase3/PARP pathway and inhibits NSCLC cell migration by suppressing MMP9 protein expression at 4-16 μM for the same duration. |
| In vivo | The anticancer agent 210, administered as a single oral dose of 400 mg/kg, showed no significant toxicity in Kunming mice. |
| Formula | C31H31BrFN7O3 |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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