Anticancer agent 210

Name: Anticancer agent 210
Brand: TargetMol
SKU: T209642
Rating: 4.5 (1 reviews)

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Catalog No. T209642

Anticanceragent 210 (Compound 7a) is a derivative of Gefitinib. It inhibits the proliferation, migration, and colony formation of cancer cells and induces apoptosis in H1299 cells.

Anticancer agent 210

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Catalog No. T209642

Anticanceragent 210 (Compound 7a) is a derivative of Gefitinib. It inhibits the proliferation, migration, and colony formation of cancer cells and induces apoptosis in H1299 cells.

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Product Introduction

Bioactivity

Description	Anticanceragent 210 (Compound 7a) is a derivative of Gefitinib. It inhibits the proliferation, migration, and colony formation of cancer cells and induces apoptosis in H1299 cells.
In vitro	Anticancer agent 210 inhibits the proliferation of lung cancer cells NCI-H1299, A549, and NCI-H1437 with IC50 values of 3.94, 3.16, and 1.84 μM, respectively, when used at concentrations of 0-32 μM for 48 hours. This compound exhibits mild cytotoxicity towards normal liver cells L02, with an IC50 of 18.87 μM and maintaining a cell survival rate of over 60% at concentrations of 2-16 μM for 48 hours. Additionally, Anticancer agent 210 induces apoptosis in non-small cell lung cancer (NSCLC) cells via the Bcl-2/caspase3/PARP pathway and inhibits NSCLC cell migration by suppressing MMP9 protein expression at 4-16 μM for the same duration.
In vivo	The anticancer agent 210, administered as a single oral dose of 400 mg/kg, showed no significant toxicity in Kunming mice.

Chemical Properties

Formula

C₃₁H₃₁BrFN₇O₃

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

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