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Anticancer agent 210
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Catalog No. T209642
Anticanceragent 210 (Compound 7a) is a derivative of Gefitinib. It inhibits the proliferation, migration, and colony formation of cancer cells and induces apoptosis in H1299 cells.
Anticancer agent 210
Anticancer agent 210
😃Good
Catalog No. T209642
Anticanceragent 210 (Compound 7a) is a derivative of Gefitinib. It inhibits the proliferation, migration, and colony formation of cancer cells and induces apoptosis in H1299 cells.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 10 mg | Inquiry | Inquiry | Inquiry | |
| 50 mg | Inquiry | Inquiry | Inquiry |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Product Introduction
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | Anticanceragent 210 (Compound 7a) is a derivative of Gefitinib. It inhibits the proliferation, migration, and colony formation of cancer cells and induces apoptosis in H1299 cells. |
| In vitro | Anticancer agent 210 inhibits the proliferation of lung cancer cells NCI-H1299, A549, and NCI-H1437 with IC50 values of 3.94, 3.16, and 1.84 μM, respectively, when used at concentrations of 0-32 μM for 48 hours. This compound exhibits mild cytotoxicity towards normal liver cells L02, with an IC50 of 18.87 μM and maintaining a cell survival rate of over 60% at concentrations of 2-16 μM for 48 hours. Additionally, Anticancer agent 210 induces apoptosis in non-small cell lung cancer (NSCLC) cells via the Bcl-2/caspase3/PARP pathway and inhibits NSCLC cell migration by suppressing MMP9 protein expression at 4-16 μM for the same duration. |
| In vivo | The anticancer agent 210, administered as a single oral dose of 400 mg/kg, showed no significant toxicity in Kunming mice. |
| Formula | C31H31BrFN7O3 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
Dose Conversion
You can also refer to dose conversion for different animals. More Dose Conversion
Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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