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DBCO-PEG-NHS (MW 2000) is a heterobifunctional PEG derivative containing a dibenzocyclooctyne (DBCO) unit for copper-free click chemistry with azides and an N-hydroxysuccinimide (NHS) ester for reaction with primary amines on proteins or peptides. The compound is an essential tool for constructing bio-orthogonal conjugation platforms, aiming to efficiently anchor ligands to nanocarriers or surfaces via a stable PEG spacer while reducing steric hindrance.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 1 mg | $195 | - | In Stock | |
| 5 mg | $483 | - | In Stock | |
| 10 mg | $691 | - | In Stock | |
| 25 mg | $1,080 | - | In Stock | |
| 50 mg | $1,490 | - | In Stock | |
| 100 mg | $1,960 | - | In Stock |
| Description | DBCO-PEG-NHS (MW 2000) is a heterobifunctional PEG derivative containing a dibenzocyclooctyne (DBCO) unit for copper-free click chemistry with azides and an N-hydroxysuccinimide (NHS) ester for reaction with primary amines on proteins or peptides. The compound is an essential tool for constructing bio-orthogonal conjugation platforms, aiming to efficiently anchor ligands to nanocarriers or surfaces via a stable PEG spacer while reducing steric hindrance. |
| In vitro | In site-specific bioconjugation assays, DBCO-PEG-NHS (MW 2000) was used to conjugate scFv fragments to the surface of liposomes while maintaining high binding affinity for human ICAM-1 [1]. |
| Molecular Weight | 2000 (Average) |
| Storage | keep away from direct sunlight,keep away from moisture,store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
Dissolve 2 mg of the compound in 100 μL DMSO
to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
1) Add 100 μL of the DMSO
stock solution to 400 μL PEG300
and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O
and mix thoroughly until a homogeneous solution is obtained.
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