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Anti-PDPK1 Antibody (6W401)

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Catalog No. TMAB-10147

Anti-PDPK1 Antibody (6W401) is a Rabbit antibody targeting PDPK1. Anti-PDPK1 Antibody (6W401) can be used in WB,IHC-P,IHC-Fr,IF,FCM.

Anti-PDPK1 Antibody (6W401)

Anti-PDPK1 Antibody (6W401)

😃Good
Catalog No. TMAB-10147
Anti-PDPK1 Antibody (6W401) is a Rabbit antibody targeting PDPK1. Anti-PDPK1 Antibody (6W401) can be used in WB,IHC-P,IHC-Fr,IF,FCM.
Pack SizePriceUSA WarehouseGlobal WarehouseQuantity
50 μL$2647-10 days7-10 days
100 μL$4727-10 days7-10 days
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Product Introduction

Bioactivity
Description
Anti-PDPK1 Antibody (6W401) is a Rabbit antibody targeting PDPK1. Anti-PDPK1 Antibody (6W401) can be used in WB,IHC-P,IHC-Fr,IF,FCM.
Ig Type
IgG
Clone
6W401
Reactivity
Human,Mouse,Rat
Application
WB
IHC-P
IHC-Fr
IF
FCM
Recommended Dose
WB: 1:500-2000; IHC-P: 1:500-2000; IHC-Fr: 1:500-2000; IF: 1:500-2000; FCM: 1:50-100
Antibody Type
Monoclonal
Host SpeciesRabbit
Subcellular LocalizationCytoplasm. Membrane; Peripheral membrane protein. Note=Membrane-associated after cell stimulation leading to its translocation. Tyrosine phosphorylation seems to occur only at the plasma membrane.
Tissue SpecificityAppears to be expressed ubiquitously.
ConstructionRecombinant Antibody
PurificationProtein A purified
AppearanceLiquid
Formulation0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
Concentration1mg/ml
Research BackgroundPDK1 (3 Phosphoinositide Dependent Protein Kinase 1) phosphorylates AGC kinases. PDK1 activates conventional PKC and PKC zeta through phosphorylation of critical threonine residues in the activation loop. PDK1 also phosphorylates Protein Kinase B (PKB) at threonine 308 in the presence of phosphatidylinositol-3,4,5-trisphosphate. Active Akt inactivates Glycogen Synthase Kinase 3 (GSK3), eventually leading to the dephosphorylation and activation of glycogen synthase and the stimulation of glycogen synthesis. Because of the role that PDK plays in insulin-induced glycogen synthesis and PKC activation it is a potentially important target for metabolic drug research. There are three named isoforms.
Antigen Details
Immunogen
KLH conjugated synthetic peptide: human PDK1
Antigen Species
Human
Gene Name
PDPK1
Gene ID
5170
Protein Name
3-phosphoinositide-dependent protein kinase 1
Uniprot ID
O15530
Function
Phosphorylates and activates not only PKB/AKT, but also PKA, PKC-zeta, RPS6KA1 and RPS6KB1. May play a general role in signaling processes and in development (By similarity). Isoform 3 is catalytically inactive.
Chemical Properties
Molecular WeightTheoretical: 61 kDa.
Stability & Storage
Stability & StorageStore at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles.
TransportShipping with blue ice.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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