ProTx-III

Name: ProTx-III
Brand: TargetMol
SKU: T80169
Rating: 4.5 (1 reviews)

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Catalog No. T80169

Alias μ-TRTX-Tp1a

ProTx-III, a spider venom peptide derived from the Peruvian green velvet tarantula, functions as a selective and potent inhibitor of the voltage-gated sodium channel Na v 1.7, exhibiting an IC 50 of 2.1 nM. Characterized by its inhibitor cystine knot motif (ICK), ProTx-III can attenuate the pain response and is applicable in research on chronic pain, epilepsy, and arrhythmia [1].

ProTx-III

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Catalog No. T80169Alias μ-TRTX-Tp1a

Pack Size	Price	Availability	Quantity
5 mg	Inquiry	Backorder
50 mg	Inquiry	Backorder

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Product Introduction

Bioactivity

Description	ProTx-III, a spider venom peptide derived from the Peruvian green velvet tarantula, functions as a selective and potent inhibitor of the voltage-gated sodium channel Na v 1.7, exhibiting an IC 50 of 2.1 nM. Characterized by its inhibitor cystine knot motif (ICK), ProTx-III can attenuate the pain response and is applicable in research on chronic pain, epilepsy, and arrhythmia [1].
Targets&IC50	Nav1.7:2.1 nM
In vitro	Natural, recombinant, and synthetic C-terminal (acid and amide) forms of ProTx-III exhibit IC50 values for the inhibition of hNav1.7 at 2.1, 9.5, 11.5, and 2.5 nM, respectively [1]. ProTx-III suppresses hNav1.7 without significantly altering the voltage dependency of its activation or inactivation [1].
In vivo	ProTx-III (0.01-1 μM; intraplantar injection) reversibly mitigated spontaneous pain in a mouse model induced by intraplantar OD1 injection, demonstrating its analgesic properties [1].
Alias	μ-TRTX-Tp1a

Chemical Properties

Molecular Weight	3802.4
Formula	C₁₆₂H₂₄₆N₅₂O₄₃S₆
Sequence	Asp-Cys-Leu-Lys-Phe-Gly-Trp-Lys-Cys-Asn-Pro-Arg-Asn-Asp-Lys-Cys-Cys-Ser-Gly-Leu-Lys-Cys-Gly-Ser-Asn-His-Asn-Trp-Cys-Lys-Leu-His-Ile-NH2 (Disulfide bonds: Cys2-Cys17, Cys9-Cys22, Cys16-Cys29)
Sequence Short	DCLKFGWKCNPRNDKCCSGLKCGSNHNWCKLHI (Disulfide bonds: Cys2-Cys17, Cys9-Cys22, Cys16-Cys29)

Storage & Solubility Information

Storage

keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc