Powder: -20°C for 3 years | In solvent: -80°C for 1 year
A011, a potent and selective ataxia-telangiectasia mutated (ATM) inhibitor, exhibits an IC50 of 1.0 nM and triggers apoptosis as well as G2/M phase cell cycle arrest when combined with CPT-11, displaying notable antitumor activity [1].
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | 35 days | $ 143.00 | |
5 mg | 35 days | $ 668.00 |
Description | A011, a potent and selective ataxia-telangiectasia mutated (ATM) inhibitor, exhibits an IC50 of 1.0 nM and triggers apoptosis as well as G2/M phase cell cycle arrest when combined with CPT-11, displaying notable antitumor activity [1]. |
Targets&IC50 | ATM:1.0 nM |
In vitro | Compound A011 (compound 8d) at concentrations of 10, 30, and 100 nM applied for 5 days increases the sensitivity of SW620 and HCT116 cells to CPT-11 (100 nM) [1]. When administered in conjunction with CPT-11 at doses ranging from 0 to 100 nM for 24 and 72 hours, A011 induces apoptosis and cell cycle arrest at the G2/M phase [1]. Furthermore, A011 at concentrations of 3, 9, 27, 83, and 250 nM reduces the expression of p-ATM and p-Chk2 in a dose-dependent manner in SW620 cells under irradiation conditions of 1.5 or 3 Gy [1]. |
In vivo | A011 (5 mg/kg; intraperitoneal injection; daily for 23 days) combined with CPT-11 (5 mg/kg, intraperitoneal injection; once weekly) demonstrated antitumor activity in mice [1]. |
Molecular Weight | 452.55 |
Formula | C27H28N6O |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
You can also refer to dose conversion for different animals. More
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A011 DNA Damage/DNA Repair PI3K/Akt/mTOR signaling ATM/ATR inhibitor inhibit