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AZ12672857

Name: AZ12672857
Brand: TargetMol
SKU: T9650
Price: 64 USD
Availability: InStock
Rating: 5 (10 reviews)

🥰Excellent

Catalog No. T9650Cas No. 945396-55-4

AZ12672857 is an inhibitor of EphB4 with IC50 of 1.3 nM. AZ12672857 inhibits cell proliferation of Src transfected 3T3 cells with IC50 of 2 nM and autophosphorylation of EphB4 in transfected CHO-K1 cells with IC50 of 9 nM.

AZ12672857

🥰Excellent

Purity: 98.99%

Catalog No. T9650Cas No. 945396-55-4

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$64	In Stock	In Stock
2 mg	$94	In Stock	In Stock
5 mg	$157	In Stock	In Stock
10 mg	$273	In Stock	In Stock
25 mg	$447	In Stock	In Stock
50 mg	$696	In Stock	In Stock
100 mg	$942	-	In Stock
1 mL x 10 mM (in DMSO)	$169	In Stock	In Stock

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Expected start date of shipmentUSA Warehouse [1-2 days] Global Warehouse [5-7 days]

This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products. However, due to objective factors, there is a small probability that the synthesis may not be successful during the R&D process. We appreciate your understanding. If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.

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Batch Information

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Purity:98.99%

Resource Download

COA HNMR LCMS

Product Introduction

Bioactivity

Description	AZ12672857 is an inhibitor of EphB4 with IC50 of 1.3 nM. AZ12672857 inhibits cell proliferation of Src transfected 3T3 cells with IC50 of 2 nM and autophosphorylation of EphB4 in transfected CHO-K1 cells with IC50 of 9 nM.
In vitro	AZ12672857 shows IC50s of 240 nM and 58 nM for p-KDR in HUVEC and p-PDGFR-β in MG63 cell line. AZ12672857 moderately inhibits CYP P450 with IC50s of 5 μM for 2C9 and 3A4 and >10 μM for 1A4, 2D6 and 2C19[1].

Chemical Properties

Molecular Weight	486.57
Formula	C₂₆H₃₀N₈O₂
Cas No.	945396-55-4
Smiles	CN(c1ccnc(Nc2cc(cc(c2)N2CCOCC2)N2CCOCC2)n1)c1cccc2[nH]ncc12
Color	Red
Appearance	Solid

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 50 mg/mL (102.76 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (4.11 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.0552 mL	10.2760 mL	20.5520 mL	102.7601 mL
5 mM	0.4110 mL	2.0552 mL	4.1104 mL	20.5520 mL
10 mM	0.2055 mL	1.0276 mL	2.0552 mL	10.2760 mL
20 mM	0.1028 mL	0.5138 mL	1.0276 mL	5.1380 mL
50 mM	0.0411 mL	0.2055 mL	0.4110 mL	2.0552 mL
100 mM	0.0206 mL	0.1028 mL	0.2055 mL	1.0276 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc