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Anti-PIK3R1 Antibody (5D427) (Synonyms: PtdIns-3-kinase regulatory subunit p85-alpha, PtdIns-3-kinase regulator...)
Catalog No. TMAH-00980 Copy Product Info
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Anti-PIK3R1 Antibody (5D427) is an antibody targeting PIK3R1. Anti-PIK3R1 Antibody (5D427) can be used in ELISA,IHC.
Anti-PIK3R1 Antibody (5D427)
Copy Product Info🥰Excellent
Catalog No. TMAH-00980
Synonyms PtdIns-3-kinase regulatory subunit p85-alpha, PtdIns-3-kinase regulatory subunit alpha, PI3-kinase subunit p85-alpha, PI3-kinase regulatory subunit alpha, PI3K regulatory subunit alpha, Phosphatidylinositol 3-kinase regulatory subunit alpha, Phosphatidylinositol 3-kinase 85 kDa regulatory subunit alpha, GRB1
Anti-PIK3R1 Antibody (5D427) is an antibody targeting PIK3R1. Anti-PIK3R1 Antibody (5D427) can be used in ELISA,IHC.
Anti-PIK3R1 Antibody
(5D427)
(5D427)
| Pack Size | Price | USA Stock | Global Stock | Quantity |
|---|---|---|---|---|
| 50 μL | $208 | 7-10 days | 7-10 days | |
| 100 μL | $349 | 7-10 days | 7-10 days |
For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)
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For research use only—not for human use. No sales to individuals. Use as intended only.
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Product Introduction
Bioactivity
Related Conjugates and Formulations
Antigen Details
Chemical Properties
Stability & Storage
| Description | Anti-PIK3R1 Antibody (5D427) is an antibody targeting PIK3R1. Anti-PIK3R1 Antibody (5D427) can be used in ELISA,IHC. |
| Synonyms | PtdIns-3-kinase regulatory subunit p85-alpha, PtdIns-3-kinase regulatory subunit alpha, PI3-kinase subunit p85-alpha, PI3-kinase regulatory subunit alpha, PI3K regulatory subunit alpha, Phosphatidylinositol 3-kinase regulatory subunit alpha, Phosphatidylinositol 3-kinase 85 kDa regulatory subunit alpha, GRB1 |
| Ig Type | Rabbit IgG |
| Clone | 5D427 |
| Reactivity | Human |
| Verified Activity | 1. IHC image of TMAH-00980 diluted at 1:50 and staining in paraffin-embedded human lung tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a Goat anti-rabbit polymer IgG labeled by HRP and visualized using 0.63% DAB. 2. IHC image of TMAH-00980 diluted at 1:50 and staining in paraffin-embedded human rectal cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a Goat anti-rabbit polymer IgG labeled by HRP and visualized using 0.63% DAB. |
| Application | |
| Recommended Dose | IHC:1:50-1:200. |
| Antibody Type | Monoclonal |
| Tissue Specificity | Isoform 2 is expressed in skeletal muscle and brain, and at lower levels in kidney and cardiac muscle. Isoform 2 and isoform 4 are present in skeletal muscle (at protein level). |
| Construction | Recombinant Antibody |
| Purification | Affinity-chromatography |
| Appearance | Liquid |
| Formulation | Phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
| Research Background | Binds to activated (phosphorylated) protein-Tyr kinases, through its SH2 domain, and acts as an adapter, mediating the association of the p110 catalytic unit to the plasma membrane. Necessary for the insulin-stimulated increase in glucose uptake and glycogen synthesis in insulin-sensitive tissues. Plays an important role in signaling in response to FGFR1, FGFR2, FGFR3, FGFR4, KITLG/SCF, KIT, PDGFRA and PDGFRB. Likewise, plays a role in ITGB2 signaling. Modulates the cellular response to ER stress by promoting nuclear translocation of XBP1 isoform 2 in a ER stress- and/or insulin-dependent manner during metabolic overloading in the liver and hence plays a role in glucose tolerance improvement. |
| Conjucates | Unconjugated |
| Immunogen | A synthetic peptide: Human PIK3R1 |
| Antigen Species | Human |
| Gene Name | PIK3R1 |
| Gene ID | |
| Uniprot ID | |
| Biology Area | Cancer, Immunology, Signal transduction |
| Stability & Storage | Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| Transport | Shipping with blue ice. |
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