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Vanillic Acid

Name: Vanillic Acid
Brand: TargetMol
SKU: T9115
Price: 41 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T9115Cas No. 121-34-6

Alias Vanillate, Acide vanillique, 4-hydroxy-3-methoxybenzoic acid

Vanillic Acid (Acide vanillique) is used as a condiment in food,which used in wine and vinegar. It is an intermediate in the production of vanillin from ferulic acid.

Vanillic Acid

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Purity: 99.82%

Catalog No. T9115Alias Vanillate, Acide vanillique, 4-hydroxy-3-methoxybenzoic acidCas No. 121-34-6

Vanillic Acid (Acide vanillique) is used as a condiment in food,which used in wine and vinegar. It is an intermediate in the production of vanillin from ferulic acid.

Pack Size	Price	USA Warehouse	Global Warehouse	Quantity
100 mg	$41	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$45	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.82%

Appearance:Solid

Color:White

Resource Download

COA HPLC LCMS HNMR

Product Introduction

Vanillic Acid AI Summary

Vanillic Acid exhibits a range of bioactivities across various biological models and assays. It inhibits purified human kidney thiopurine methyltransferase (TPMT) with an IC50 value of 478,630.09 nM and shows antitubercular activity against Mycobacterium tuberculosis with MIC values of 375,000.0 nM and 238,000.0 nM for different strains. The compound also inhibits Saccharomyces sp. alpha-glucosidase with an IC50 of 69,000.0 nM and exhibits anti-inflammatory activity in CD1 mice by reducing croton oil-induced ear edema by 20.0% at a concentration of 0.3 μmol/cm² after 6 hours. It shows moderate inhibition of nitric oxide production in mouse macrophages and a slight inhibition of beta-hexosaminidase in anti-DNP IgE sensitized rat cells. Vanillic Acid also demonstrates inhibitory activity against pieris rapae Phenoloxidase, human recombinant aldose reductase, and soybean 15-lipoxygenase. In assays assessing its antitumor properties, it inhibits cell growth in various human and mouse cell lines, though typically at high concentrations (IC50 values greater than 1,000,000.0 nM). In terms of its antioxidant activity, Vanillic Acid shows efficacy in the DPPH and ABTS radical scavenging assays. It also demonstrates cytotoxicity against several human cell lines, including OE21 and LoVo cells, with IC50 values ranging from 61,000 to 91,000 nM. Additionally, it exhibits activity as a lipid storage modulator in Drosophila cells and acts as an inhibitor for Plasmodium falciparum enoyl-ACP reductase. Vanillic Acid inhibits the interaction between specific proteins used in FRET assays, shows hepatoprotective effects in rat WB-F344 cells against D-galactosamine-induced toxicity, and displays antifeedant activity against pine weevils. Moreover, it demonstrates mild inhibition of mushroom tyrosinase and possesses nematotoxic activity against root-knot nematodes, although its efficacy in these areas appears limited. Overall, Vanillic Acid shows a broad spectrum of bioactivities, including enzyme inhibition, anti-inflammatory, antitubercular, antioxidant, cytotoxic, hepatoprotective, and neuroprotective properties, although its effectiveness can vary significantly across different assays and biological systems..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	Vanillic Acid (Acide vanillique) is used as a condiment in food,which used in wine and vinegar. It is an intermediate in the production of vanillin from ferulic acid.
Synonyms	Vanillate, Acide vanillique, 4-hydroxy-3-methoxybenzoic acid

Chemical Properties

Molecular Weight	168.15
Formula	C₈H₈O₄
Cas No.	121-34-6
Smiles	O(C)C1=CC(C(O)=O)=CC=C1O
Relative Density.	1.3037 g/cm3 (Estimated)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 260 mg/mL (1546.24 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 5 mg/mL (29.74 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	5.9471 mL	29.7354 mL	59.4707 mL	297.3536 mL
5 mM	1.1894 mL	5.9471 mL	11.8941 mL	59.4707 mL
10 mM	0.5947 mL	2.9735 mL	5.9471 mL	29.7354 mL
20 mM	0.2974 mL	1.4868 mL	2.9735 mL	14.8677 mL
50 mM	0.1189 mL	0.5947 mL	1.1894 mL	5.9471 mL
100 mM	0.0595 mL	0.2974 mL	0.5947 mL	2.9735 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc