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CCR1 antagonist 9

🥰Excellent
Catalog No. T10710Cas No. 1220026-26-5

CCR1 antagonist 9 (compound 19e) is a selective CCR1 antagonist based on aziridine. It exhibits an IC50 of 6.8 nM for CCR1 inhibition in calcium flux assays and an IC50 of 30 μM for hERG.

CCR1 antagonist 9

CCR1 antagonist 9

🥰Excellent
Purity: 99.13%
Catalog No. T10710Cas No. 1220026-26-5
CCR1 antagonist 9 (compound 19e) is a selective CCR1 antagonist based on aziridine. It exhibits an IC50 of 6.8 nM for CCR1 inhibition in calcium flux assays and an IC50 of 30 μM for hERG.
Pack SizePriceUSA WarehouseGlobal WarehouseQuantity
1 mg$100-In Stock
5 mg$247-In Stock
10 mg$413-In Stock
25 mg$758-In Stock
50 mg$1,090-In Stock
100 mg$1,590-In Stock
1 mL x 10 mM (in DMSO)$272-In Stock
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Purity:99.13%
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COA HNMR FNMR LCMS

Product Introduction

Bioactivity
Description
CCR1 antagonist 9 (compound 19e) is a selective CCR1 antagonist based on aziridine. It exhibits an IC50 of 6.8 nM for CCR1 inhibition in calcium flux assays and an IC50 of 30 μM for hERG.
Targets&IC50
CCR1:6.8 nM
In vitro
CCR1 antagonist 9 blocks the CCR1 chemotaxis of THP-1 cells (IC50: 28 nM) and also blocks hERG (IC50: 30 μM) [1].
Chemical Properties
Molecular Weight425.44
FormulaC20H16FN5O3S
Cas No.1220026-26-5
SmilesO=C(NCC=1C=CN=C(C1)S(=O)(=O)C)C2=CN=CC3=C2C=NN3C4=CC=C(F)C=C4
Relative Density.1.46 g/cm3 (Predicted)
ColorWhite
AppearanceSolid
Storage & Solubility Information
Storagestore at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
DMSO: 64 mg/mL (150.43 mM), Sonication is recommended.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM2.3505 mL11.7525 mL23.5051 mL117.5254 mL
5 mM0.4701 mL2.3505 mL4.7010 mL23.5051 mL
10 mM0.2351 mL1.1753 mL2.3505 mL11.7525 mL
20 mM0.1175 mL0.5876 mL1.1753 mL5.8763 mL
50 mM0.0470 mL0.2351 mL0.4701 mL2.3505 mL
100 mM0.0235 mL0.1175 mL0.2351 mL1.1753 mL

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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.
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Keywords

CCR-1 antagonist 9CCR1 antagonist 9CCR1
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