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CCR1 antagonist 9

Name: CCR1 antagonist 9
Brand: TargetMol
SKU: T10710
Price: 100 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T10710Cas No. 1220026-26-5

CCR1 antagonist 9 (compound 19e) is a selective CCR1 antagonist based on aziridine. It exhibits an IC50 of 6.8 nM for CCR1 inhibition in calcium flux assays and an IC50 of 30 μM for hERG.

CCR1 antagonist 9

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Purity: 99.13%

Catalog No. T10710Cas No. 1220026-26-5

CCR1 antagonist 9 (compound 19e) is a selective CCR1 antagonist based on aziridine. It exhibits an IC50 of 6.8 nM for CCR1 inhibition in calcium flux assays and an IC50 of 30 μM for hERG.

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$100	-	In Stock
5 mg	$247	-	In Stock
10 mg	$413	-	In Stock
25 mg	$758	-	In Stock
50 mg	$1,090	-	In Stock
100 mg	$1,590	-	In Stock
1 mL x 10 mM (in DMSO)	$272	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:99.13%

Resource Download

COA HNMR FNMR LCMS

Product Introduction

Bioactivity

Description	CCR1 antagonist 9 (compound 19e) is a selective CCR1 antagonist based on aziridine. It exhibits an IC50 of 6.8 nM for CCR1 inhibition in calcium flux assays and an IC50 of 30 μM for hERG.
Targets&IC50	CCR1:6.8 nM
In vitro	CCR1 antagonist 9 blocks the CCR1 chemotaxis of THP-1 cells (IC50: 28 nM) and also blocks hERG (IC50: 30 μM) [1].

Chemical Properties

Molecular Weight	425.44
Formula	C₂₀H₁₆FN₅O₃S
Cas No.	1220026-26-5
Smiles	O=C(NCC=1C=CN=C(C1)S(=O)(=O)C)C2=CN=CC3=C2C=NN3C4=CC=C(F)C=C4
Relative Density.	1.46 g/cm3 (Predicted)
Color	White
Appearance	Solid

Storage & Solubility Information

Storage

store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 64 mg/mL (150.43 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween-80+45% Saline: 2.5 mg/mL (5.88 mM), Sonication is recommeded.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.3505 mL	11.7525 mL	23.5051 mL	117.5254 mL
5 mM	0.4701 mL	2.3505 mL	4.7010 mL	23.5051 mL
10 mM	0.2351 mL	1.1753 mL	2.3505 mL	11.7525 mL
20 mM	0.1175 mL	0.5876 mL	1.1753 mL	5.8763 mL
50 mM	0.0470 mL	0.2351 mL	0.4701 mL	2.3505 mL
100 mM	0.0235 mL	0.1175 mL	0.2351 mL	1.1753 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc