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FKBP12 PROTAC dTAG-13

Name: FKBP12 PROTAC dTAG-13
Brand: TargetMol
SKU: T11291
Price: 74 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T11291Cas No. 2064175-41-1

Alias dTAG-13

FKBP12 PROTAC dTAG-13 is a PROTAC and selective degrader that can be used for target validation during drug discovery by splicing FKBP12 F36V with CRBN and thereby degrading FKBP12 F36V.

FKBP12 PROTAC dTAG-13

🥰Excellent

Purity: 97.31%

Catalog No. T11291Alias dTAG-13Cas No. 2064175-41-1

FKBP12 PROTAC dTAG-13 is a PROTAC and selective degrader that can be used for target validation during drug discovery by splicing FKBP12 F36V with CRBN and thereby degrading FKBP12 F36V.

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$74	In Stock	In Stock
5 mg	$163	In Stock	In Stock
10 mg	$239	In Stock	In Stock
25 mg	$393	In Stock	In Stock
50 mg	$598	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

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Batch Information

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Purity:97.31%

Resource Download

COA LCMS HNMR

Product Introduction

Bioactivity

Description	FKBP12 PROTAC dTAG-13 is a PROTAC and selective degrader that can be used for target validation during drug discovery by splicing FKBP12 F36V with CRBN and thereby degrading FKBP12 F36V.
In vitro	FKBP12 PROTAC dTAG-13 selectively degrades FKBP12^F36V fusion proteins without affecting wild-type FKBP12. In 293T, PATU-8988T, and EOL-1 cells, FKBP12 PROTAC dTAG-13 (500 nM, 4 h) effectively degraded FKBP12^F36V-KRAS^G12V or FKBP12^F36V-ABL1 and suppressed downstream signaling. Dose-dependent degradation was observed from 10 to 500 nM[1].
In vivo	In NOD/SCID mice bearing PATU-8988T FKBP12^F36V-KRAS^G12V xenografts, a single intraperitoneal dose of FKBP12 PROTAC dTAG-13 (35 mg/kg) reduced fusion protein levels in tumors within 2 h, lasting ≥12 h[1].
Synonyms	dTAG-13

Chemical Properties

Molecular Weight	1049.17
Formula	C₅₇H₆₈N₄O₁₅
Cas No.	2064175-41-1
Smiles	O=C1C=2C(C(=O)N1C3C(=O)NC(=O)CC3)=CC=CC2OCCCCCCNC(COC4=C([C@H](OC(=O)[C@H]5N(C([C@@H](CC)C6=CC(OC)=C(OC)C(OC)=C6)=O)CCCC5)CCC7=CC(OC)=C(OC)C=C7)C=CC=C4)=O
Relative Density.	1.260 g/cm3 (Predicted)
Color	White
Appearance	Solid

Storage & Solubility Information

Storage

store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 80 mg/mL (76.25 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+90% Corn Oil: 3.3 mg/mL (3.15 mM), Sonication is recommeded.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	0.9531 mL	4.7657 mL	9.5313 mL	47.6567 mL
5 mM	0.1906 mL	0.9531 mL	1.9063 mL	9.5313 mL
10 mM	0.0953 mL	0.4766 mL	0.9531 mL	4.7657 mL
20 mM	0.0477 mL	0.2383 mL	0.4766 mL	2.3828 mL
50 mM	0.0191 mL	0.0953 mL	0.1906 mL	0.9531 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc