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FKBP12 PROTAC dTAG-13

🥰Excellent
Catalog No. T11291Cas No. 2064175-41-1
Alias dTAG-13

FKBP12 PROTAC dTAG-13 is a PROTAC and selective degrader that can be used for target validation during drug discovery by splicing FKBP12 F36V with CRBN and thereby degrading FKBP12 F36V.

FKBP12 PROTAC dTAG-13

FKBP12 PROTAC dTAG-13

🥰Excellent
Purity: 97.31%
Catalog No. T11291Alias dTAG-13Cas No. 2064175-41-1
FKBP12 PROTAC dTAG-13 is a PROTAC and selective degrader that can be used for target validation during drug discovery by splicing FKBP12 F36V with CRBN and thereby degrading FKBP12 F36V.
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1 mg$74In Stock
5 mg$163In Stock
25 mgInquiryIn Stock
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Purity:97.31%
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Product Introduction

Bioactivity
Description
FKBP12 PROTAC dTAG-13 is a PROTAC and selective degrader that can be used for target validation during drug discovery by splicing FKBP12 F36V with CRBN and thereby degrading FKBP12 F36V.
In vitro
FKBP12 PROTAC dTAG-13 selectively degrades FKBP12^F36V fusion proteins without affecting wild-type FKBP12. In 293T, PATU-8988T, and EOL-1 cells, FKBP12 PROTAC dTAG-13 (500 nM, 4 h) effectively degraded FKBP12^F36V-KRAS^G12V or FKBP12^F36V-ABL1 and suppressed downstream signaling. Dose-dependent degradation was observed from 10 to 500 nM[1].
In vivo
In NOD/SCID mice bearing PATU-8988T FKBP12^F36V-KRAS^G12V xenografts, a single intraperitoneal dose of FKBP12 PROTAC dTAG-13 (35 mg/kg) reduced fusion protein levels in tumors within 2 h, lasting ≥12 h[1].
AliasdTAG-13
Chemical Properties
Molecular Weight1049.17
FormulaC57H68N4O15
Cas No.2064175-41-1
SmilesO=C1C=2C(C(=O)N1C3C(=O)NC(=O)CC3)=CC=CC2OCCCCCCNC(COC4=C([C@H](OC(=O)[C@H]5N(C([C@@H](CC)C6=CC(OC)=C(OC)C(OC)=C6)=O)CCCC5)CCC7=CC(OC)=C(OC)C=C7)C=CC=C4)=O
Relative Density.1.260 g/cm3 (Predicted)
Storage & Solubility Information
Storagestore at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
DMSO: 80 mg/mL (76.25 mM), Sonication is recommended.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM0.9531 mL4.7657 mL9.5313 mL47.6567 mL
5 mM0.1906 mL0.9531 mL1.9063 mL9.5313 mL
10 mM0.0953 mL0.4766 mL0.9531 mL4.7657 mL
20 mM0.0477 mL0.2383 mL0.4766 mL2.3828 mL
50 mM0.0191 mL0.0953 mL0.1906 mL0.9531 mL

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