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Rufloxacin hydrochloride
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Catalog No. TQ0221Cas No. 106017-08-7
Alias MF-934 hydrochloride
Rufloxacin hydrochloride (MF-934 hydrochloride) is a fluoroquinolone antibacterial that inhibits topoisomerase and B-cell differentiation in human mononuclear cells.
Rufloxacin hydrochloride
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Purity: 99.80%
Catalog No. TQ0221Alias MF-934 hydrochlorideCas No. 106017-08-7
Rufloxacin hydrochloride (MF-934 hydrochloride) is a fluoroquinolone antibacterial that inhibits topoisomerase and B-cell differentiation in human mononuclear cells.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 25 mg | $35 | In Stock | In Stock | |
| 50 mg | $48 | In Stock | In Stock | |
| 100 mg | $72 | In Stock | In Stock | |
| 200 mg | $105 | In Stock | In Stock |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Batch Information
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Purity:99.80%
Appearance:Solid
Color:White
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Product Introduction
Rufloxacin hydrochloride AI Summary
Rufloxacin hydrochloride shows bioactivity across a spectrum of biological assays targeting various enzymes and pathogens. It exhibits nanomolar potency in inhibiting enzymes such as HSD17B4, JMJD2E, ALDH1A1, HPGD, HADH2, and the histone lysine methyltransferase G9a. The compound also demonstrates inhibitory activity against non-replicating, drug-tolerant Mycobacterium tuberculosis, the malarial parasite plastid, and specific regions in Salmonella Typhimurium and Salmonella typhi. Furthermore, Rufloxacin hydrochloride inhibits cellular entry mechanisms of the Ebola virus.
In terms of antiviral activity, Rufloxacin hydrochloride shows efficacy against SARS-CoV-2 by inhibiting cytotoxicity in Caco-2 cells and VERO-6 cells at a concentration of 10 µM, with reported inhibition rates of 17.62% and 0.01% respectively after 48 hours. It also inhibits the SARS-CoV-2 3CL-Pro protease with an inhibition rate of 12.56% at a 20 µM concentration.
Additionally, Rufloxacin hydrochloride displays antifungal activity against Candida albicans and Cryptococcus neoformans with MIC values greater than 10,000 nM. Its antibacterial activity spans various bacteria, including Escherichia coli (MIC 1,250 nM), Pseudomonas aeruginosa (MIC 10,000 nM), Staphylococcus aureus MRSA (MIC 2,500 nM), Klebsiella pneumoniae, and Acinetobacter baumannii (both with MIC values greater than 10,000 nM). It has a cytotoxicity (CC50) greater than 10,000 nM against HEK293 cells. Overall, Rufloxacin hydrochloride exhibits a broad range of bioactivities against enzymes, pathogens, and viruses..
Note: Summary generated by AI. Data source: ChEMBL 
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | Rufloxacin hydrochloride (MF-934 hydrochloride) is a fluoroquinolone antibacterial that inhibits topoisomerase and B-cell differentiation in human mononuclear cells. |
| Synonyms | MF-934 hydrochloride |
| Molecular Weight | 399.867 |
| Formula | C17H19ClFN3O3S |
| Cas No. | 106017-08-7 |
| Smiles | Cl.CN1CCN(CC1)c1c(F)cc2c3c1SCCn3cc(C(O)=O)c2=O |
| Relative Density. | no data available |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | H2O: 1 mg/mL (2.5 mM), Sonication is recommended. DMSO: 0.08 mg/mL (0.2 mM), Sonication and heating are recommended. |
Calculator
In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
Dose Conversion
You can also refer to dose conversion for different animals. More Dose Conversion
Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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