Ligases or Synthetases,EC 6

Expression system: Baculovirus Insect Cells
Length: 2-471, Full Length of Mature Protein
Activity: Not Tested

UBE1, also known as UBA1, belongs to the ubiquitin-activating E1 family. UBE1 gene complements an X-linked mouse temperature-sensitive defect in DNA synthesis, and thus may function in DNA repair. It is part of a gene cluster on chromosome Xp11.23. UBE1 catalyzes the first step in ubiquitin conjugation to mark cellular proteins for degradation. It also catalyzes the first step in ubiquitin conjugation to mark cellular proteins for degradation by first adenylating its C-terminal glycine residue with ATP, and thereafter linking this residue to the side chain of a cysteine residue in E1, yielding a ubiquitin-E1 thioester and free AMP. Defects in UBA1 can cause spinal muscular atrophy X-linked type 2 (SMAX2), also known as X-linked lethal infantile spinal muscular atrophy, distal X-linked arthrogryposis multiplex congenita or X-linked arthrogryposis type 1 (AMCX1). Spinal muscular atrophy refers to a group of neuromuscular disorders characterized by degeneration of the anterior horn cells of the spinal cord, leading to symmetrical muscle weakness and atrophy. SMAX2 is a lethal infantile form presenting with hypotonia, areflexia, and multiple congenital contractures.

Expression system: E. coli
Length: 100-581, Partial
Activity: Not Tested

Expression system: E. coli
Length: 2-373, Full Length of Mature Protein
Activity: Not Tested

UBA6 (Ubiquitin Like Modifier Activating Enzyme 6) is a Protein Coding gene. The UBA6 gene, located on 4q13.2, is conserved in chimpanzee, Rhesus monkey, dog, cow, mouse, rat, chicken, zebrafish, and frog. Uba6 is a homolog of the ubiquitin-activating enzyme, Uba1, and activates two ubiquitin-like proteins (UBLs), ubiquitin and FAT10. UBA6 is an alternative enzyme for ubiquitin activation in vertebrates that plays a pivotal role in early mouse development. UBA6 is widely expressed in the lymph node, appendix, and other tissues. Diseases associated with UBA6 include Ichthyosis, Congenital, Autosomal Recessive 4A, and Johanson-Blizzard Syndrome. Among its related pathways are the Metabolism of proteins and the Innate Immune System.

Expression system: E. coli
Length: 1-465, Full Length
Activity: Not Tested

Expression system: P. pastoris (Yeast)
Length: 38-689, Full Length of Mature Protein
Activity: Not Tested

Expression system: E. coli
Length: 1354-1500, Partial
Activity: Not Tested

Expression system: E. coli
Length: 1-356, Full Length
Activity: Not Tested

Expression system: E. coli
Length: 1-586, Full Length
Activity: Not Tested

Expression system: E. coli
Length: 217-775, Partial
Activity: Not Tested

Expression system: E. coli
Length: 1064-1302, Partial
Activity: Not Tested

GARS Protein, Human, Recombinant (His) is expressed in Baculovirus insect cells with His tag. The predicted molecular weight is 85.5 kDa and the accession number is P41250-1.

Glutathione Synthetase belongs to the eukaryotic GSH synthase family. Glutathione Synthetase is the second enzyme in the glutathione biosynthesis pathway. It catalyses the condensation of gamma-glutamylcysteine and glycine to form glutathione. Glutathione play an important role in a variety of biological functions, including detoxification of xenobiotics, protection of cells from oxidative damage by free radicals, and membrane transport. The protein functions as a homodimer to catalyze the second step of glutathione biosynthesis, which is the ATP-dependent conversion of gamma-L-glutamyl-L-cysteine to glutathione. Defects in Glutathione Synthetase can also cause the glutathione synthetase deficiency of erythrocytes, which is a mild form causing hemolytic anemia.

Expression system: E. coli
Length: 2-373, Full Length of Mature Protein
Activity: Not Tested

Expression system: E. coli
Length: 38-689, Full Length of Mature Protein
Activity: Not Tested

Expression system: HEK293 Cells
Length: 9-127, Partial
Activity: Not Tested

Expression system: E. coli
Length: 217-775, Partial
Activity: Not Tested

Expression system: E. coli
Length: 78-617, Partial
Activity: Not Tested

Expression system: E. coli
Length: 1-503, Full Length
Activity: Not Tested

Expression system: E. coli
Length: 2-528, Full Length of Mature Protein
Activity: Not Tested

Expression system: E. coli
Length: 551-743, Partial
Activity: Not Tested

Expression system: E. coli
Length: 1-591, Full Length
Activity: Not Tested

HARS HisRS Protein, Human, Recombinant (His) is expressed in Baculovirus insect cells with His tag. The predicted molecular weight is 59.6 kDa and the accession number is P12081-1.