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Clonidine hydrochloride

Name: Clonidine hydrochloride
Brand: TargetMol
SKU: T1247
Price: 30 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T1247Cas No. 4205-91-8

Alias Clonidine HCl, Catapres

Clonidine hydrochloride (Catapres) is a centrally active α-adrenergic agonist used predominantly as an antihypertensive agent.

Clonidine hydrochloride

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Purity: 99.86%

Catalog No. T1247Alias Clonidine HCl, CatapresCas No. 4205-91-8

Clonidine hydrochloride (Catapres) is a centrally active α-adrenergic agonist used predominantly as an antihypertensive agent.

Pack Size	Price	USA Warehouse	Global Warehouse	Quantity
500 mg	$30	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$30	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

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Purity:99.86%

Color:White

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COA LCMS HNMR

Product Introduction

Bioactivity

Description	Clonidine hydrochloride (Catapres) is a centrally active α-adrenergic agonist used predominantly as an antihypertensive agent.
In vitro	Clonidine, at concentrations of 0.01, 0.1, or 1 μM, significantly elevates CGRP (α and β) mRNA expression in endothelial cells in a dose-dependent manner. Additionally, a 24-hour treatment with 1 μM clonidine notably augments NO levels in these cells. This indicates that the NO pathway plays a crucial role in modulating the clonidine-induced CGRP production[2].
In vivo	Administered intraperitoneally at a dose of 50 μg/kg, clonidine markedly reduces rat body temperature, peaking at 1 hour and persisting for 3 hours; this effect is notably counteracted by a pre-administration of phentolamine into the cerebral ventricles[1]. Additionally, clonidine (0.003-0.05 mg/kg, i.p.) effectively inhibits PCP-induced dopamine release in the prefrontal cortex, an effect that is blocked by the alpha-2A receptor antagonist BRL-44408[3]. In normotensive rats treated with DMSO, clonidine (0.6 μg intracisternally) does not alter blood pressure, but following central adenosine A1R inhibition with DPCPX, it significantly lowers blood pressure. Conversely, in DMSO-treated aortic-banded rats, clonidine prominently decreases blood pressure, a response that remains unchanged after DPCPX pretreatment. Additionally, in SO rats with central A1R blockage, clonidine not only reduces blood pressure but also significantly elevates pERK1/2 levels in the RVLM, an effect not observed in DMSO-pretreated SO rats. Similarly, clonidine boosts RVLM pERK1/2 levels in vehicle-treated aortic-banded rats, unaffected by DPCPX[4].
Synonyms	Clonidine HCl, Catapres

Chemical Properties

Molecular Weight	266.55
Formula	C₉H₁₀Cl₃N₃
Cas No.	4205-91-8
Smiles	Cl.ClC1=CC=CC(Cl)=C1NC1=NCCN1
Relative Density.	no data available

Storage & Solubility Information

Storage

In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

H2O: 26.7 mg/mL (100.17 mM), Sonication is recommended.

DMSO: 23.33 mg/mL (87.53 mM), Sonication is recommended.

Solution Preparation Table

DMSO/H2O

	1mg	5mg	10mg	50mg
1 mM	3.7516 mL	18.7582 mL	37.5164 mL	187.5821 mL
5 mM	0.7503 mL	3.7516 mL	7.5033 mL	37.5164 mL
10 mM	0.3752 mL	1.8758 mL	3.7516 mL	18.7582 mL
20 mM	0.1876 mL	0.9379 mL	1.8758 mL	9.3791 mL
50 mM	0.0750 mL	0.3752 mL	0.7503 mL	3.7516 mL

H2O

	1mg	5mg	10mg	50mg
100 mM	0.0375 mL	0.1876 mL	0.3752 mL	1.8758 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc