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Anti-Presenilin 1 Antibody (5C43)
😃Good
Catalog No. TMAB-11730
Anti-Presenilin 1 Antibody (5C43) is a Rabbit antibody targeting Presenilin 1. Anti-Presenilin 1 Antibody (5C43) can be used in FCM,IHC-P,IHC-Fr,IF.
Anti-Presenilin 1 Antibody (5C43)
Anti-Presenilin 1 Antibody (5C43)
😃Good
Catalog No. TMAB-11730
Anti-Presenilin 1 Antibody (5C43) is a Rabbit antibody targeting Presenilin 1. Anti-Presenilin 1 Antibody (5C43) can be used in FCM,IHC-P,IHC-Fr,IF.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 25 μL | $150 | 7-10 days | 7-10 days | |
| 50 μL | $262 | 7-10 days | 7-10 days | |
| 100 μL | $471 | 7-10 days | 7-10 days |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Product Introduction
Bioactivity
Antigen Details
Chemical Properties
| Description | Anti-Presenilin 1 Antibody (5C43) is a Rabbit antibody targeting Presenilin 1. Anti-Presenilin 1 Antibody (5C43) can be used in FCM,IHC-P,IHC-Fr,IF. |
| Ig Type | IgG |
| Clone | 5C43 |
| Reactivity | Human,Mouse,Rat |
| Application | |
| Recommended Dose | FCM: 1:50-100; IHC-P: 1:50-200; IHC-Fr: 1:50-200; IF: 1:50-200 |
| Antibody Type | Monoclonal |
| Host Species | Rabbit |
| Subcellular Localization | Endoplasmic reticulum membrane; Multi-pass membrane protein. Golgi apparatus membrane; Multi-pass membrane protein. Cell surface. Note=Bound to NOTCH1 also at the cell surface. Colocalizes with CDH1/2 at sites of cell-cell contact. Colocalizes with CTNNB1 in the endoplasmic reticulum and the proximity of the plasma membrane. Also present in azurophil granules of neutrophils. |
| Tissue Specificity | Expressed in a wide range of tissues including various regions of the brain, liver, spleen and lymph nodes. |
| Construction | Recombinant Antibody |
| Purification | Protein A purified |
| Appearance | Liquid |
| Formulation | 10mM phosphate buffered saline (pH 7.4) with 150mM sodium chloride, 0.05% BSA, 0.02% Proclin300 and 50% glycerol. |
| Research Background | Requires the presence of the other members of the gamma-secretase complex for protease activity.Plays a role in Notch and Wnt signaling cascades and regulation of downstream processes via its role in processing key regulatory proteins, and by regulating cytosolic CTNNB1 levels. |
| Immunogen | A synthesized peptide: human Presenilin 1 |
| Antigen Species | Human |
| Gene Name | PSEN1 |
| Gene ID | |
| Protein Name | Presenilin-1 |
| Uniprot ID | |
| Function | Probable catalytic subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (beta-amyloid precursor protein). Requires the other members of the gamma-secretase complex to have a protease activity. May play a role in intracellular signaling and gene expression or in linking chromatin to the nuclear membrane. Stimulates cell-cell adhesion though its association with the E-cadherin/catenin complex. Under conditions of apoptosis or calcium influx, cleaves E-cadherin promoting the disassembly of the E-cadherin/catenin complex and increasing the pool of cytoplasmic beta-catenin, thus negatively regulating Wnt signaling. May also play a role in hematopoiesis. |
| Molecular Weight | Theoretical: 53 kDa. Actual: 28 kDa. |
Stability & Storage
| Stability & Storage | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| Transport | Shipping with blue ice. |
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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