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MOZ-IN-2

Name: MOZ-IN-2
Brand: TargetMol
SKU: T12098
Price: 31 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T12098Cas No. 2055397-88-9

MOZ-IN-2 is an protein MOZ inhibitor(IC50 of 125 μM).

MOZ-IN-2

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Purity: 99.17%

Catalog No. T12098Cas No. 2055397-88-9

MOZ-IN-2 is an protein MOZ inhibitor(IC50 of 125 μM).

Pack Size	Price	USA Warehouse	Global Warehouse
2 mg	$31	In Stock	In Stock
5 mg	$55	In Stock	In Stock
10 mg	$97	In Stock	In Stock
25 mg	$198	In Stock	In Stock
50 mg	$297	In Stock	In Stock
100 mg	$455	In Stock	In Stock
500 mg	$987	-	In Stock
1 mL x 10 mM (in DMSO)	$61	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.17%

Appearance:Solid

Color:White

Resource Download

COA HNMR LCMS

Product Introduction

MOZ-IN-2 AI Summary

MOZ-IN-2 inhibits the N-terminal NusA-fused His6-tagged human KAT6A enzyme expressed in Escherichia coli BL21 (DE3) cells, tested with acetyl coenzyme A and N-terminal histone H4 peptide substrates using AlphaScreen technology, with an IC50 value greater than 125,000.0 nM, indicating low potency. It also exhibits varying bioactivities in different cell types: showing both inhibitory and stimulatory effects in HEK293T cells, inhibitory effects in U2OS cells, and stimulatory effects in human fibroblast cells, suggesting cell-type-specific interactions. Biochemically, it inhibits MetAP2 with an IC50 greater than 50000.0 nM and demonstrates inhibitory effects on several GPCR targets and strong inhibition of DAT (80.15%). Additionally, it affects the thermal stability of various protein domains, generally resulting in decreased stability. The compound shows a weaker affinity for the MYST3 enzyme with an IC50 greater than 50000.0 nM, and does not exhibit significant binding affinity (Ki > 10000.0 nM) for the adrenergic receptor subtype ADRA2A or the dopamine transporter SLC6A3..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	MOZ-IN-2 is an protein MOZ inhibitor(IC50 of 125 μM).
Targets&IC50	MOZ:125 μM (IC50)

Chemical Properties

Molecular Weight	372.37
Formula	C₁₇H₁₃FN₄O₃S
Cas No.	2055397-88-9
Smiles	Fc1ccc(cc1C(=O)NNS(=O)(=O)c1ccccc1)-c1ccnnc1
Relative Density.	1.409 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 120 mg/mL (322.26 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 4 mg/mL (10.74 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.6855 mL	13.4275 mL	26.8550 mL	134.2750 mL
5 mM	0.5371 mL	2.6855 mL	5.3710 mL	26.8550 mL
10 mM	0.2686 mL	1.3428 mL	2.6855 mL	13.4275 mL
20 mM	0.1343 mL	0.6714 mL	1.3428 mL	6.7138 mL
50 mM	0.0537 mL	0.2686 mL	0.5371 mL	2.6855 mL
100 mM	0.0269 mL	0.1343 mL	0.2686 mL	1.3428 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc