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Sodium salicylate

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Catalog No. T0335Cas No. 54-21-7
Alias Salicylic acid sodium salt, 2-Hydroxybenzoic acid sodium salt

Sodium salicylate (2-Hydroxybenzoic acid sodium salt), a metabolite of acetylsalicylic acid, can inhibit NF-kB and reduce oxidative stress.

Sodium salicylate
Other Forms of Sodium salicylate:

Sodium salicylate

🥰Excellent
Purity: 99.92%
Catalog No. T0335Alias Salicylic acid sodium salt, 2-Hydroxybenzoic acid sodium saltCas No. 54-21-7
Sodium salicylate (2-Hydroxybenzoic acid sodium salt), a metabolite of acetylsalicylic acid, can inhibit NF-kB and reduce oxidative stress.
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500 mg$45In StockIn Stock
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Purity:99.92%
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Product Introduction

Bioactivity
Description
Sodium salicylate (2-Hydroxybenzoic acid sodium salt), a metabolite of acetylsalicylic acid, can inhibit NF-kB and reduce oxidative stress.
In vitro
Sodium salicylate acts as non-steroidal anti-inflammatory drug (NSAID), and induces apoptosis in cancer cells and also necrosis. Sodium salicylate inhibits the activation of NF-kappa B, and also inhibits NF-kappa B-dependent transcription from the Ig kappa enhancer and the human immunodeficiency virus (HIV) long terminal repeat (LTR) in transfected T cells. [1] Sodium salicylate also induces apoptosis via p38 MAPK and inhibits TNF-induced JNK/stress-activated protein kinase activation. [2]
SynonymsSalicylic acid sodium salt, 2-Hydroxybenzoic acid sodium salt
Chemical Properties
Molecular Weight160.11
FormulaC7H5NaO3
Cas No.54-21-7
Smiles[Na+].Oc1ccccc1C(=O)[O-]
Relative Density.0.56 g/cm3. Temperature:25 °C.
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
DMSO: 50 mg/mL (312.29 mM), Sonication is recommended.
Ethanol: < 1 mg/mL (insoluble or slightly soluble)
H2O: 29 mg/mL (181.13 mM), Sonication is recommended.
In Vivo Formulation
10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (12.49 mM), Sonication is recommended.
Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.
Solution Preparation Table
H2O/DMSO
1mg5mg10mg50mg
1 mM6.2457 mL31.2285 mL62.4571 mL312.2853 mL
5 mM1.2491 mL6.2457 mL12.4914 mL62.4571 mL
10 mM0.6246 mL3.1229 mL6.2457 mL31.2285 mL
20 mM0.3123 mL1.5614 mL3.1229 mL15.6143 mL
50 mM0.1249 mL0.6246 mL1.2491 mL6.2457 mL
100 mM0.0625 mL0.3123 mL0.6246 mL3.1229 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.
1 Enter information below:
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2 Enter the in vivo formulation:
% DMSO
%
% Tween 80
% Saline/PBS/ddH2O

Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

Sodium SalicylateSodium salicylateSodiumSalicylic acid sodiumSalicylic acidS6KinaseS6KS6 KinaseRibosomal S6 Kinase (RSK)Nuclear factor-κBNuclear factor-kappaBNF-κBNFκBNF-kBNFkBNaSalInhibitorinhibitEndogenous MetaboliteCyclooxygenaseCOX-3COX-1COXAutophagyApoptosis2-Hydroxybenzoic acid sodium2-Hydroxybenzoic acid
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