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ODM-203 sodium is an orally available, selective, and efficient FGFR and VEGFR inhibitor, with antitumor activity, inhibiting FGFR3/1/2 and VEGFR3/2/1/4, inducing antitumor immunity, useful in solid tumor research.

| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 1 mg | $157 | Backorder | Backorder | |
| 5 mg | $347 | Backorder | Backorder |
| Description | ODM-203 sodium is an orally available, selective, and efficient FGFR and VEGFR inhibitor, with antitumor activity, inhibiting FGFR3/1/2 and VEGFR3/2/1/4, inducing antitumor immunity, useful in solid tumor research. |
| Targets&IC50 | MAP4K4:49 nM, DDR1:6 nM, FGFR1:11 nM, VEGFR2:9 nM, VEGFR3:5 nM, FGFR2:16 nM, PDGFRα:35 nM, RET:8 nM, SIK3:23 nM, VEGFR1:26 nM |
| In vitro | ODM-203 sodium (1, 10, 100, 1000 nM, 1 hour) inhibits FGFR and VEGFR cell signaling in HUVEC cells.[1] |
| In vivo | Methods: ODM-203 sodium (20, 40 mg/kg, oral, once a day, 21 days) was used to treat several tumor xenograft model mice and observe the tumor growth in the mice. Results: ODM-203 sodium inhibited FGFR phosphorylation and tumor growth in several FGFR-dependent xenografts by inhibiting FGFR signaling in tumors. [1] |
| Synonyms | ODM-203 sodium(1430723-35-5 Free base), ODM203 sodium salt, AUR-109 sodium salt, AUR109 sodium salt |
| Molecular Weight | 527.52 |
| Formula | C26H20F2N5NaO2S |
| Smiles | [Na+].Cn1cc(cn1)-c1ccc2n(cnc2c1)-c1cc([N-]S(=O)(=O)C2CC2)cc(c1)-c1ccc(F)cc1F |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
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