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ODM-203 sodium
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Catalog No. T7611L
Alias ODM-203 sodium（1430723-35-5 Free base）, ODM203 sodium salt, AUR-109 sodium salt, AUR109 sodium salt
ODM-203 sodium is an orally available, selective, and efficient FGFR and VEGFR inhibitor, with antitumor activity, inhibiting FGFR3/1/2 and VEGFR3/2/1/4, inducing antitumor immunity, useful in solid tumor research.
ODM-203 sodium
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Purity: 99.89%
Catalog No. T7611LAlias ODM-203 sodium（1430723-35-5 Free base）, ODM203 sodium salt, AUR-109 sodium salt, AUR109 sodium salt
ODM-203 sodium is an orally available, selective, and efficient FGFR and VEGFR inhibitor, with antitumor activity, inhibiting FGFR3/1/2 and VEGFR3/2/1/4, inducing antitumor immunity, useful in solid tumor research.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 1 mg | $157 | Inquiry | Inquiry | |
| 5 mg | $347 | Inquiry | Inquiry |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Purity:99.89%
Appearance:Solid
Color:Gray
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Product Introduction
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | ODM-203 sodium is an orally available, selective, and efficient FGFR and VEGFR inhibitor, with antitumor activity, inhibiting FGFR3/1/2 and VEGFR3/2/1/4, inducing antitumor immunity, useful in solid tumor research. |
| Targets&IC50 | FGFR2:16 nM, PDGFRα:35 nM, VEGFR3:5 nM, SIK3:23 nM, MAP4K4:49 nM, VEGFR1:26 nM, FGFR1:11 nM, DDR1:6 nM, RET:8 nM, VEGFR2:9 nM |
| In vitro | ODM-203 sodium (1, 10, 100, 1000 nM, 1 hour) inhibits FGFR and VEGFR cell signaling in HUVEC cells.[1] |
| In vivo | Methods: ODM-203 sodium (20, 40 mg/kg, oral, once a day, 21 days) was used to treat several tumor xenograft model mice and observe the tumor growth in the mice. Results: ODM-203 sodium inhibited FGFR phosphorylation and tumor growth in several FGFR-dependent xenografts by inhibiting FGFR signaling in tumors. [1] |
| Synonyms | ODM-203 sodium（1430723-35-5 Free base）, ODM203 sodium salt, AUR-109 sodium salt, AUR109 sodium salt |
| Molecular Weight | 527.52 |
| Formula | C26H20F2N5NaO2S |
| Smiles | [Na+].Cn1cc(cn1)-c1ccc2n(cnc2c1)-c1cc([N-]S(=O)(=O)C2CC2)cc(c1)-c1ccc(F)cc1F |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
Calculator
In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
Dose Conversion
You can also refer to dose conversion for different animals. More Dose Conversion
Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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