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Antibody-drug Conjugate/ADC Related Filter
Antibody-drug Conjugate/ADC RelatedPROTAC-Linker Conjugates for PAC
PROTAC-Linker Conjugates for PAC are composed of PROTAC and bifunctional or multifunctional linkers, which can be further linked to antibodies through the linkers to form PAC. The antibodies in PAC can target specific antigens on the cell membrane surface, helping PROTAC effectively locate on the cell membrane surface and thereby enter the cell through cytotoxic effects.
MC-GGFG-DX8951
MC-GGFG-Exatecan
T160241600418-29-8
MC-GGFG-DX8951 (MC-GGFG-Exatecan) is an antibody-coupled drug (ADC) drug-linker conjugate (DLC) consisting of DX8951, a potent DNA topoisomerase I inhibitor, the linker MC, and the cleavable peptide chain GGFG, and has antitumor potential.
Drug-Linker Conjugates for ADCPROTAC-Linker Conjugates for PACPROTAC-Linker Conjugates for PACTopoisomerase
- $113
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PROTAC BRD4 degrader for PAC-1
T18603
PROTAC BRD4 degrader for PAC-1 (compound 5) is a chimeric BET degrader GNE-987 conjugated with a disulfide-containing linker[1]. This PROTAC-linker conjugate specifically targets and degrades BRD4, enabling selective proteolysis of PAC-1.
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Diazobenzenesulfonic acid
Diazobenzenesulphonate, Diazobenzenesulfonate, diazobenzene sulfonic acid, Diazobenzene sulfonate, DASA
T239922154-66-7
Diazobenzenesulfonic acid is a desensitizer (inhibitor) of allosteric effect for myosin ATPase 13.
- $293
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PROTAC BRD4 Degrader-13
PROTAC BRD4 Degrader-13
T400752417370-71-7
PROTAC BRD4 Degrader-13 (compound 9d) is a bioactive compound functioning as a proteolysis targeting chimera (PROTAC) by linking ligands for von Hippel-Lindau and BRD4 proteins. In PC3 prostate cancer cells, it effectively degrades the BRD4 protein through conjugation with STEAP1 and CLL1 antibodies, exhibiting a DC50 of 0.025 nM and 6.0 nM, respectively.
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PROTAC BRD4 Degrader-12
T741252417370-90-0
PROTAC BRD4 Degrader-12 (compound 9c) is a PROTAC that links von Hippel-Lindau and BRD4 ligands. When conjugated with STEAP1 and CLL1 antibodies, this compound effectively degrades BRD4 protein in PC3 prostate cancer cells, demonstrating potent activity with DC50 values of 0.39 nM and 0.24 nM, respectively [1].
Epigenetic Reader DomainOthersPROTAC-Linker Conjugates for PACPROTAC-Linker Conjugates for PACPROTACs
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PAC
T185142158322-33-7
PAC is a chemical conjugate consisting of an ADCs linker and PROTACs linked to an antibody. When PAC is conjugated to an antibody, it exhibits enhanced degradation of estrogen receptor-alpha (ERα) in comparison to PROTAC alone.
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MC-(β-Ala)-PABC-(β-D-GlcUA)-amide-PEG1-CH2-CC-885
T877082722697-86-9
MC-(β-Ala)-PABC-(β-D-GlcUA)-amide-PEG1-CH2-CC-885 (Comp Ie) serves as a neodegrader conjugate instrumental in the synthesis of antibody neoDegrader conjugate (AnDC) [1].
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PROTAC BTK Degrader-8
T208958
PROTACBTK Degrader-8 (compound 3) is an efficient PROTAC BTK degrader with a linker that can couple with ADC antibodies to form PAC.
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PROTAC BRD4 Degrader-11
T74124
PROTAC BRD4 Degrader-11 (compound 9a), a PROTAC linked through ligands to von Hippel-Lindau and BRD4, effectively targets and degrades the BRD4 protein in PC3 prostate cancer cells when conjugated with STEAP1 and CLL1 antibodies, exhibiting potent activity with DC50 values of 0.23 nM and 0.38 nM for the respective conjugations [1].
Epigenetic Reader DomainOthersPROTAC-Linker Conjugates for PACPROTAC-Linker Conjugates for PACPROTACs
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cBu-Cit-PROTAC BRD4 Degrader-5
T881572417369-73-2
cBu-Cit-PROTAC BRD4 Degrader-5, a cBu-Cit conjugated PROTAC degrader, effectively degrades BRD4 in both HER2 positive and negative breast cancer cell lines.
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