Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Vesnarinone HCl (OPC-8212 HCl) is an orally active phosphodiesterase 3 (PDE3) inhibitor.Vesnarinone HCl modulates calcium and potassium ions, increasing calcium flux and decreasing potassium flux.Vesnarinone HCl is a new positive inotropic compound that enhances myocardial contractility and can be be used in heart failure studies.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 50.00 | |
5 mg | In stock | $ 89.00 | |
10 mg | In stock | $ 133.00 | |
25 mg | In stock | $ 223.00 | |
50 mg | In stock | $ 396.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 77.00 |
Description | Vesnarinone HCl (OPC-8212 HCl) is an orally active phosphodiesterase 3 (PDE3) inhibitor.Vesnarinone HCl modulates calcium and potassium ions, increasing calcium flux and decreasing potassium flux.Vesnarinone HCl is a new positive inotropic compound that enhances myocardial contractility and can be be used in heart failure studies. |
Targets&IC50 | PDE3A:10.7 μM, PDE3B:13.2 μM, ERG1:1.1 μM |
In vitro |
Vesnarine (60 and 100 μg/mL; 48 h) in a dose-dependent manner to inhibit cell growth.[3] Vesnarine (60 μg/mL; 48 h) induces G1 phase arrest and cell apoptosis.[3] Vesnarine (60 μg/mL; 0, 12, 24, and 48 h) increased the expression of p21 mRNA and slightly decreased the p21 protein.[3] |
In vivo |
Vesnarinone (3-300 μM) increases contractile tension in isolated ventricular muscles of dogs, cats, rabbits, and guinea pig in a dose-dependent manner.[5] Vesnarinone (Oral and i.v.) administration of vesnarinone increases right ventricular pressure with no effect on heart rate in dog models of tricuspid insufficiency- and pulmonary stenosis-induced congestive heart failure. It also increases contractility and coronary flow while decreasing heart rate in a guinea pig model of aortic stenosis-induced congestive heart failure. Formulations containing vesnarinone have been used for the treatment of congestive heart failure.[6] |
Synonyms | Synonym 2, OPC-8212 HCl, Vesnarinone HCl(81840-15-5 Free base) |
Molecular Weight | 431.91 |
Formula | C22H26ClN3O4 |
CAS No. | T3465L |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
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Vesnarinone HCl T3465L Membrane transporter/Ion channel Metabolism Calcium Channel Potassium Channel PDE Synonym 2 OPC-8212 HCl Vesnarinone HCl(81840-15-5 Free base) inhibitor inhibit