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Lutikizumab (Synonyms: ABT-981)

Catalog No. T77077 Copy Product Info
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Lutikizumab is a bispecific antibody against IL-1α and IL-1β with a bivalent variable domain structure. By binding to IL-1α and IL-1β, Lutikizumab effectively inhibits their activity and is mainly used in the field of osteoarthritis research.

Lutikizumab

Copy Product Info
🥰Excellent
Catalog No. T77077
Synonyms ABT-981

Lutikizumab is a bispecific antibody against IL-1α and IL-1β with a bivalent variable domain structure. By binding to IL-1α and IL-1β, Lutikizumab effectively inhibits their activity and is mainly used in the field of osteoarthritis research.

Lutikizumab
Cas No. 1791411-57-8
Pack SizePriceUSA StockGlobal StockQuantity
1 mg$456-In Stock
5 mg$1,160-In Stock
10 mg$1,850-In Stock
For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)
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With extensive experience in compound synthesis, we can provide rapid custom synthesis services for this product according to your research needs.
For research use only—not for human use. No sales to individuals. Use as intended only.
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Batch Information

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Purity:>95% (SDS-PAGE); 99.63% (SEC-HPLC)
Appearance:Liquid
Color:Transparent
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Product Introduction

Bioactivity
Description
Lutikizumab is a bispecific antibody against IL-1α and IL-1β with a bivalent variable domain structure. By binding to IL-1α and IL-1β, Lutikizumab effectively inhibits their activity and is mainly used in the field of osteoarthritis research.
In vitro
Lutikizumab binds specifically to both human IL‑1α and IL‑1β proteins.Compared with other cytokines in the IL‑1 family, lutikizumab exhibits highly specific binding to both IL‑1α and IL‑1β [1].
In vivo
Lutikizumab significantly inhibits IL‑6 production induced by IL‑1α and IL‑1β following a single intraperitoneal injection at doses of 0.0001–1 mg/kg [1].
SynonymsABT-981
Reactivity
Human
Application
Functional assay
Antibody Type
Monoclonal, Bispecific
FormulationSupplied as a sterile solution in a buffered formulation system (e.g., phosphate-, citrate-, or amino acid-based). Please refer to the CoA for lot-specific composition.
Endotoxin<1.0 EU/mg
Related Conjugates and Formulations
Conjucates
Unconjugated
Antigen Details
Gene ID
Uniprot ID
TargetIL-1α/IL-1β
Chemical Properties
Molecular Weight196.82 kDa
Cas No.1791411-57-8
Antibody Information
IsotypeHuman IgG1 kappa
Recommended Isotype Control
Storage & Solubility Information
StorageStore at -20°C Shipping with blue ice/Shipping at ambient temperature.

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