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Lutikizumab is a bispecific antibody against IL-1α and IL-1β with a bivalent variable domain structure. By binding to IL-1α and IL-1β, Lutikizumab effectively inhibits their activity and is mainly used in the field of osteoarthritis research.

| Pack Size | Price | USA Stock | Global Stock | Quantity |
|---|---|---|---|---|
| 1 mg | $456 | - | In Stock | |
| 5 mg | $1,160 | - | In Stock | |
| 10 mg | $1,850 | - | In Stock |
| Description | Lutikizumab is a bispecific antibody against IL-1α and IL-1β with a bivalent variable domain structure. By binding to IL-1α and IL-1β, Lutikizumab effectively inhibits their activity and is mainly used in the field of osteoarthritis research. |
| In vitro | Lutikizumab binds specifically to both human IL‑1α and IL‑1β proteins.Compared with other cytokines in the IL‑1 family, lutikizumab exhibits highly specific binding to both IL‑1α and IL‑1β [1]. |
| In vivo | Lutikizumab significantly inhibits IL‑6 production induced by IL‑1α and IL‑1β following a single intraperitoneal injection at doses of 0.0001–1 mg/kg [1]. |
| Synonyms | ABT-981 |
| Reactivity | Human |
| Application | Functional assay |
| Antibody Type | Monoclonal, Bispecific |
| Formulation | Supplied as a sterile solution in a buffered formulation system (e.g., phosphate-, citrate-, or amino acid-based). Please refer to the CoA for lot-specific composition. |
| Endotoxin | <1.0 EU/mg |
| Conjucates | Unconjugated |
| Gene ID | |
| Uniprot ID | |
| Target | IL-1α/IL-1β |
| Molecular Weight | 196.82 kDa |
| Cas No. | 1791411-57-8 |
| Isotype | Human IgG1 kappa |
| Recommended Isotype Control |
| Storage | Store at -20°C Shipping with blue ice/Shipping at ambient temperature. |
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