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20-HETE
(Synonyms: 20-hydroxy Arachidonic Acid) Copy Product Info
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Synonyms: 20-hydroxy Arachidonic Acid
Catalog No. T14021 Copy Product Info
Purity: 99.79%
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20-HETE belongs to endogenous metabolites (natural products) and is a protein kinase C (PKC) pathway activator that promotes ACSL4 ubiquitination and degradation through upregulation of FBXO10, possessing regulatory properties on cell proliferation and migration. This compound is used in research related to prostate tumors and cardiac hypertrophy.
Cas No. 79551-86-3
| Pack Size | Price | USA Stock | Global Stock | Quantity |
|---|---|---|---|---|
| 100 μg (312.04 μM * 1 mL in Ethanol) | $498 | In Stock | In Stock | |
| 1 mg (312.04 μM * 10 mL in Ethanol) | $1,198 | - | In Stock | |
| 5 mg (312.04 μM * 50 mL in Ethanol) | $3,360 | - | In Stock |
For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)
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For research use only—not for human use. No sales to individuals. Use as intended only.
Batch Information
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Purity:99.79%
Appearance:Liquid
Color:Transparent
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Product Introduction
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | 20-HETE belongs to endogenous metabolites (natural products) and is a protein kinase C (PKC) pathway activator that promotes ACSL4 ubiquitination and degradation through upregulation of FBXO10, possessing regulatory properties on cell proliferation and migration. This compound is used in research related to prostate tumors and cardiac hypertrophy. |
| In vitro | Methods: Treatment with 17-ODYA (1 μM) was used to observe large-conductance Ca²⁺-activated K⁺ channel activity, with reversal by 20-HETE (10 nM); isolated perfused small renal arteries from rats were treated with 20-HETE (1-1000 nM), and the vasoconstrictor response was blocked with TEA (1 mM). Results: 17-ODYA increased channel activity, which was reversed by 20-HETE; 20-HETE dose-dependently reduced arterial diameter by approximately 15%, and this constrictor response was blocked by TEA. [1] |
| In vivo | Methods: Male Sprague-Dawley rats received intraperitoneal injections of DHT (56 mg/kg/day, dissolved in 20% benzyl benzoate corn oil) for 21 consecutive days to induce hypertension, with concurrent administration of reserpine (100 μg/kg/day, dissolved in DMSO) or combined administration of 20-HEDGE (10 mg/kg/day, dissolved in 5% ethanol saline). Results: Reserpine completely prevented DHT-induced elevation of blood pressure, but did not affect the increases in medial thickness, media/lumen ratio, and collagen IV deposition in renal interlobular arteries; whereas combined administration of 20-HEDGE significantly inhibited these parameters, confirming that 20-HETE directly mediates DHT-induced microvascular remodeling independent of elevated blood pressure.[2] |
| Synonyms | 20-hydroxy Arachidonic Acid |
| Molecular Weight | 320.47 |
| Formula | C20H32O3 |
| Cas No. | 79551-86-3 |
| Smiles | C(=C\C/C=C\C/C=C\CCCCCO)\C/C=C\CCCC(O)=O |
| Relative Density. | 0.985g/cm3 |
| Storage | Store at low temperature Pure form: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature. | |||||||||||||||||||||||||
| Solubility Information | DMSO: 2 mg/mL (6.24 mM), Sonication is recommended. Ethanol: 5 mg/mL (15.6 mM), Sonication is recommended. | |||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||
DMSO/Ethanol
Ethanol
Note : The dilution table applies only to solid products. For liquid products, please calculate the stock solution based on the stated concentration and/or density. | ||||||||||||||||||||||||||
Calculator
In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
Dose Conversion
You can also refer to dose conversion for different animals. More Dose Conversion
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Related Tags: 20-HETE chemical structure | 20-HETE in vivo | 20-HETE in vitro | 20-HETE formula | 20-HETE molecular weight
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