HGFR/c-Met Protein, Mouse, Recombinant (hFc)

Catalog No. TMPY-01895

HGFR/c-Met Protein, Mouse, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 128 kDa and the accession number is A4FUV6.

HGFR/c-Met Protein, Mouse, Recombinant (hFc)

Catalog No. TMPY-01895

HGFR/c-Met Protein, Mouse, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 128 kDa and the accession number is A4FUV6.

Pack Size	Price	Availability	Quantity
100 μg	$498	7-10 days
1 mg	$3,270	7-10 days

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Product Information

Biological Activity	Measured by its binding ability in a functional ELISA. Immobilized human HGF at 2 μg/ml (100 μl/well) can bind mouse HGFR with a linear range of 1.28-32ng/ml.
Description	HGFR/c-Met Protein, Mouse, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 128 kDa and the accession number is A4FUV6.
Species	Mouse
Expression System	HEK293 Cells
Tag	C-hFc
Accession Number	A4FUV6
Synonyms	Par4,MET proto-oncogene, receptor tyrosine kinase,HGFR,HGF,c-Met,AI838057
Construction	A DNA sequence encoding the mouse MET (NP_032617.2) extracellular domain (Met 1-Asn 929) was fused with the Fc region of human IgG1 at the C-terminus. Predicted N terminal: Glu 25 & Ser 307
Protein Purity	> 92 % as determined by SDS-PAGE
Molecular Weight	128 kDa (predicted); 43 kDa and 115-120 kDa (reducing condition, due to glycosylation)
Endotoxin	< 1.0 EU/μg of the protein as determined by the LAL method.
Formulation	Lyophilized from a solution filtered through a 0.22 μm filter, containing PBS, pH 7.4. Typically, a mixture containing 5% to 8% trehalose, mannitol, and 0.01% Tween 80 is incorporated as a protective agent before lyophilization.
Reconstitution	A Certificate of Analysis (CoA) containing reconstitution instructions is included with the products. Please refer to the CoA for detailed information.
Stability & Storage	It is recommended to store recombinant proteins at -20°C to -80°C for future use. Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at -80°C. For reconstituted protein solutions, the solution can be stored at -20°C to -80°C for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.
Shipping	In general, Lyophilized powders are shipping with blue ice.
Research Background	Hepatocyte growth factor receptor (HGFR), also known as c-Met or mesenchymal-epithelial transition factor (MET), is a receptor tyrosine kinase (RTK) that is overexpressed and/or mutated in a variety of malignancies. HGFR protein is produced as a single-chain precursor, and HGF is the only known ligand. Normal HGF/HGFR signaling is essential for embryonic development, tissue repair, or wound healing, whereas aberrantly active HGFR has been strongly implicated in tumorigenesis, particularly in the development of invasive and metastatic phenotypes. HGFR protein is a multifaceted regulator of growth, motility, and invasion, and is normally expressed by cells of epithelial origin. Preclinical studies suggest that targeting aberrant HGFR signaling could be an attractive therapy in cancer.Cancer ImmunotherapyImmune CheckpointImmunotherapyTargeted Therapy