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6-Hydroxymelatonin

🥰Excellent
Catalog No. T13520Cas No. 2208-41-5

6-Hydroxymelatonin is the main active metabolite and endogenous metabolite of Melatonin via CYP1A2, an agonist of MT2 receptor with antioxidant and neuroprotective effects, and effectively reduces KCN-induced lipid peroxidation and superoxide anion production.

6-Hydroxymelatonin

6-Hydroxymelatonin

🥰Excellent
Catalog No. T13520Cas No. 2208-41-5
6-Hydroxymelatonin is the main active metabolite and endogenous metabolite of Melatonin via CYP1A2, an agonist of MT2 receptor with antioxidant and neuroprotective effects, and effectively reduces KCN-induced lipid peroxidation and superoxide anion production.
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1 mg$149-In Stock
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Product Introduction

Bioactivity
Description
6-Hydroxymelatonin is the main active metabolite and endogenous metabolite of Melatonin via CYP1A2, an agonist of MT2 receptor with antioxidant and neuroprotective effects, and effectively reduces KCN-induced lipid peroxidation and superoxide anion production.
In vitro
In mouse cortical neuron mitochondria, 6-Hydroxymelatonin (1-10 μM, 30 min) significantly reduced ROS and H₂O₂ and protected against APP⁺-induced oxidative stress[1].
Chemical Properties
Molecular Weight248.28
FormulaC13H16N2O3
Cas No.2208-41-5
SmilesO=C(NCCC1=CNC=2C=C(O)C(OC)=CC21)C
Relative Density.1.266g/cm3
ColorWhite
AppearanceSolid
Storage & Solubility Information
Storagekeep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
DMSO: 40 mg/mL (161.11 mM), Sonication is recommended.
In Vivo Formulation
10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (8.06 mM), Sonication is recommended.
Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM4.0277 mL20.1386 mL40.2771 mL201.3855 mL
5 mM0.8055 mL4.0277 mL8.0554 mL40.2771 mL
10 mM0.4028 mL2.0139 mL4.0277 mL20.1386 mL
20 mM0.2014 mL1.0069 mL2.0139 mL10.0693 mL
50 mM0.0806 mL0.4028 mL0.8055 mL4.0277 mL
100 mM0.0403 mL0.2014 mL0.4028 mL2.0139 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.
1 Enter information below:
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2 Enter the in vivo formulation:
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%
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Keywords

Human Endogenous Metabolite
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