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6-Hydroxymelatonin is the main active metabolite and endogenous metabolite of Melatonin via CYP1A2, an agonist of MT2 receptor with antioxidant and neuroprotective effects, and effectively reduces KCN-induced lipid peroxidation and superoxide anion production.
Description | 6-Hydroxymelatonin is the main active metabolite and endogenous metabolite of Melatonin via CYP1A2, an agonist of MT2 receptor with antioxidant and neuroprotective effects, and effectively reduces KCN-induced lipid peroxidation and superoxide anion production. |
In vitro | In mouse cortical neuron mitochondria, 6-Hydroxymelatonin (1-10 μM, 30 min) significantly reduced ROS and H₂O₂ and protected against APP⁺-induced oxidative stress[1]. |
Molecular Weight | 248.28 |
Formula | C13H16N2O3 |
Cas No. | 2208-41-5 |
Smiles | O=C(NCCC1=CNC=2C=C(O)C(OC)=CC21)C |
Relative Density. | 1.266g/cm3 |
Storage | keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. | |||||||||||||||||||||||||||||||||||
Solubility Information | DMSO: 40 mg/mL (161.11 mM), Sonication is recommended. | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
DMSO
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