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6-Hydroxymelatonin

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Catalog No. T13520Cas No. 2208-41-5

6-Hydroxymelatonin is the main active metabolite and endogenous metabolite of Melatonin via CYP1A2, an agonist of MT2 receptor with antioxidant and neuroprotective effects, and effectively reduces KCN-induced lipid peroxidation and superoxide anion production.

6-Hydroxymelatonin

6-Hydroxymelatonin

🥰Excellent
Catalog No. T13520Cas No. 2208-41-5
6-Hydroxymelatonin is the main active metabolite and endogenous metabolite of Melatonin via CYP1A2, an agonist of MT2 receptor with antioxidant and neuroprotective effects, and effectively reduces KCN-induced lipid peroxidation and superoxide anion production.
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Product Introduction

Bioactivity
Description
6-Hydroxymelatonin is the main active metabolite and endogenous metabolite of Melatonin via CYP1A2, an agonist of MT2 receptor with antioxidant and neuroprotective effects, and effectively reduces KCN-induced lipid peroxidation and superoxide anion production.
In vitro
In mouse cortical neuron mitochondria, 6-Hydroxymelatonin (1-10 μM, 30 min) significantly reduced ROS and H₂O₂ and protected against APP⁺-induced oxidative stress[1].
Chemical Properties
Molecular Weight248.28
FormulaC13H16N2O3
Cas No.2208-41-5
SmilesO=C(NCCC1=CNC=2C=C(O)C(OC)=CC21)C
Relative Density.1.266g/cm3
Storage & Solubility Information
Storagekeep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
DMSO: 40 mg/mL (161.11 mM), Sonication is recommended.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM4.0277 mL20.1386 mL40.2771 mL201.3855 mL
5 mM0.8055 mL4.0277 mL8.0554 mL40.2771 mL
10 mM0.4028 mL2.0139 mL4.0277 mL20.1386 mL
20 mM0.2014 mL1.0069 mL2.0139 mL10.0693 mL
50 mM0.0806 mL0.4028 mL0.8055 mL4.0277 mL
100 mM0.0403 mL0.2014 mL0.4028 mL2.0139 mL

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