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MS1943

Name: MS1943
Brand: TargetMol
SKU: T13780
Price: 35 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T13780Cas No. 2225938-17-8

MS1943 is a orally bioavailable EZH2 selective degrader(IC50 of 120 nM).

MS1943

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Purity: 95.82%

Catalog No. T13780Cas No. 2225938-17-8

MS1943 is a orally bioavailable EZH2 selective degrader(IC50 of 120 nM).

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$35	-	In Stock
2 mg	$50	-	In Stock
5 mg	$81	-	In Stock
10 mg	$139	-	In Stock
25 mg	$277	-	In Stock
50 mg	$488	-	In Stock
100 mg	$890	-	In Stock
200 mg	$1,470	-	In Stock
1 mL x 10 mM (in DMSO)	$129	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:95.82%

Appearance:Solid

Color:Yellow

Resource Download

COA HPLC HNMR

Product Introduction

Bioactivity

Description	MS1943 is a orally bioavailable EZH2 selective degrader(IC50 of 120 nM).
Targets&IC50	EZH2:120 nM
In vitro	MS1943 inhibits cell growth (GI50 of 2.2 μM). MS1943 induces cell death in MDA-MB-468 cells. MS1943 effectively reduces EZH2 levels in BT549, HCC70 and MDA-MB-231 TNBC cells, as well as KARPAS-422 and SUDHL8 lymphoma cells and PNT2 non-cancerous prostate cells[1].
In vivo	A single i.p. injection of MS1943 at 50 mg/kg body weight achieved a peak plasma concentration (Cmax) of 2.9 μM and resulted in plasma concentrations above its cellular IC50 value for ~2h. A single 150 mg/kg body weight p.o. dose achieved Cmax of 1.1 μM, but plasma concentrations were below the cellular IC50 value.MS1943 suppresses tumor growth[1].

Chemical Properties

Molecular Weight	718.93
Formula	C₄₂H₅₄N₈O₃
Cas No.	2225938-17-8
Smiles	CC(C)n1ncc2c(cc(cc12)-c1ccc(nc1)N1CCN(CCNC(=O)CC23CC4CC(CC(C4)C2)C3)CC1)C(=O)NCc1c(C)cc(C)[nH]c1=O
Relative Density.	1.36 g/cm3 (Predicted)

Storage & Solubility Information

Storage

keep away from direct sunlight | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 120 mg/mL (166.91 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 5 mg/mL (6.95 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.3910 mL	6.9548 mL	13.9096 mL	69.5478 mL
5 mM	0.2782 mL	1.3910 mL	2.7819 mL	13.9096 mL
10 mM	0.1391 mL	0.6955 mL	1.3910 mL	6.9548 mL
20 mM	0.0695 mL	0.3477 mL	0.6955 mL	3.4774 mL
50 mM	0.0278 mL	0.1391 mL	0.2782 mL	1.3910 mL
100 mM	0.0139 mL	0.0695 mL	0.1391 mL	0.6955 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc