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5-Methoxytryptophol

Name: 5-Methoxytryptophol
Brand: TargetMol
SKU: T13515
Price: 29 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T13515Cas No. 712-09-4

Alias Methoxytryptophol, 2-(5-Methoxy-1H-indol-3-yl)ethanol

5-Methoxytryptophol (2-(5-Methoxy-1H-indol-3-yl)ethanol) is a pineal indoleamine derived from serotonin shown to be biologically active in a number of species.

5-Methoxytryptophol

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Purity: 99.81%

Catalog No. T13515Alias Methoxytryptophol, 2-(5-Methoxy-1H-indol-3-yl)ethanolCas No. 712-09-4

5-Methoxytryptophol (2-(5-Methoxy-1H-indol-3-yl)ethanol) is a pineal indoleamine derived from serotonin shown to be biologically active in a number of species.

Pack Size	Price	USA Warehouse	Global Warehouse
50 mg	$42	-	In Stock
100 mg	$68	-	In Stock
1 mL x 10 mM (in DMSO)	$29	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

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Batch Information

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Purity:99.81%

Appearance:Liquid

Color:Yellow

Resource Download

COA LCMS HPLC HNMR

Product Introduction

Bioactivity

Description	5-Methoxytryptophol (2-(5-Methoxy-1H-indol-3-yl)ethanol) is a pineal indoleamine derived from serotonin shown to be biologically active in a number of species.
In vitro	In MC3T3-E1 cells, most of the 5-methoxytryptophol doses reduced slightly the metabolic activity of osteoblasts. After 14 days of cell culture, Rankl mRNA levels were decreased. 5-methoxytryptophol also induced a high osteocalcin secretion and mineralization capacity. In RAW264.7 cells, 5-methoxytryptophol decreased the number of osteoclast formed and its activity. 5-methoxytryptophol promoted activation of the ERK1/2 pathway through the phosphorylation of ERK, while LUZ addition suppressed this effect. In conclusion, 5-methoxytryptophol inhibits osteoclastogenesis and promoting osteoblast differentiation[3].
Synonyms	Methoxytryptophol, 2-(5-Methoxy-1H-indol-3-yl)ethanol

Chemical Properties

Molecular Weight	191.23
Formula	C₁₁H₁₃NO₂
Cas No.	712-09-4
Smiles	COC1=CC=C2NC=C(CCO)C2=C1
Relative Density.	1.224 g/cm3

Storage & Solubility Information

Storage

Pure form: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 88 mg/mL (460.18 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 3.3 mg/mL (17.26 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	5.2293 mL	26.1465 mL	52.2931 mL	261.4653 mL
5 mM	1.0459 mL	5.2293 mL	10.4586 mL	52.2931 mL
10 mM	0.5229 mL	2.6147 mL	5.2293 mL	26.1465 mL
20 mM	0.2615 mL	1.3073 mL	2.6147 mL	13.0733 mL
50 mM	0.1046 mL	0.5229 mL	1.0459 mL	5.2293 mL
100 mM	0.0523 mL	0.2615 mL	0.5229 mL	2.6147 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc