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Seclidemstat

Name: Seclidemstat
Brand: TargetMol
SKU: T4527
Price: 41 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T4527Cas No. 1423715-37-0

Alias SP-2577

Seclidemstat (SP-2577) is an effective LSD1 inhibitor, with a mean IC50 of 127 nM.

Seclidemstat

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Purity: 99.76%

Catalog No. T4527Alias SP-2577Cas No. 1423715-37-0

Seclidemstat (SP-2577) is an effective LSD1 inhibitor, with a mean IC50 of 127 nM.

Pack Size	Price	Availability
5 mg	$41	In Stock
10 mg	$66	In Stock
25 mg	$123	In Stock
50 mg	$197	In Stock
100 mg	$373	In Stock
200 mg	$556	In Stock
500 mg	$896	In Stock
1 mL x 10 mM (in DMSO)	$45	In Stock

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Batch Information

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Purity:99.76%

Resource Download

COA HNMR LCMS

Product Introduction

Bioactivity

Description	Seclidemstat (SP-2577) is an effective LSD1 inhibitor, with a mean IC50 of 127 nM.
Targets&IC50	LSD1:127 nM
Synonyms	SP-2577

Chemical Properties

Molecular Weight	450.94
Formula	C₂₀H₂₃ClN₄O₄S
Cas No.	1423715-37-0
Smiles	CN1CCN(CC1)S(=O)(=O)c1cccc(c1)C(=O)N\N=C(/C)c1cc(Cl)ccc1O
Relative Density.	1.39 g/cm3 (Predicted)
Color	Yellow
Appearance	Solid

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

H2O: < 0.1 mg/mL (insoluble)

DMSO: 100 mg/mL (221.76 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.2176 mL	11.0879 mL	22.1759 mL	110.8795 mL
5 mM	0.4435 mL	2.2176 mL	4.4352 mL	22.1759 mL
10 mM	0.2218 mL	1.1088 mL	2.2176 mL	11.0879 mL
20 mM	0.1109 mL	0.5544 mL	1.1088 mL	5.5440 mL
50 mM	0.0444 mL	0.2218 mL	0.4435 mL	2.2176 mL
100 mM	0.0222 mL	0.1109 mL	0.2218 mL	1.1088 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Sci Citations

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc