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Donitriptan

Name: Donitriptan
Brand: TargetMol
SKU: T11075
Rating: 4.5 (1 reviews)

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Catalog No. T11075Cas No. 170912-52-4

Donitriptan is a 5-HT receptor agonist with pKis of 9.4 and 9.3 for 5-HT1B and 5-HT1D, respectively.

Donitriptan

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Purity: 98.76%

Catalog No. T11075Cas No. 170912-52-4

Donitriptan is a 5-HT receptor agonist with pKis of 9.4 and 9.3 for 5-HT1B and 5-HT1D, respectively.

Pack Size	Price	Availability
1 mg	$51	6-8 weeks
2 mg	$74	6-8 weeks
5 mg	$122	6-8 weeks
10 mg	$198	6-8 weeks
25 mg	$455	6-8 weeks
50 mg	$672	6-8 weeks
1 mL x 10 mM (in DMSO)	$133	In Stock

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Bulk & Custom

This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products. However, due to objective factors, there is a small probability that the synthesis may not be successful during the R&D process. We appreciate your understanding. If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.

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Purity:98.76%

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COA

Product Introduction

Bioactivity

Description	Donitriptan is a 5-HT receptor agonist with pKis of 9.4 and 9.3 for 5-HT1B and 5-HT1D, respectively.
Targets&IC50	pki:, 5-HT1D receptor:9.3 (pki), 5-HT1B receptor:9.4 (pki)

Chemical Properties

Molecular Weight	403.48
Formula	C₂₃H₂₅N₅O₂
Cas No.	170912-52-4
Smiles	NCCc1c[nH]c2ccc(OCC(=O)N3CCN(CC3)c3ccc(cc3)C#N)cc12
Relative Density.	1.31g/cm3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 245 mg/mL (607.22 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.4784 mL	12.3922 mL	24.7844 mL	123.9219 mL
5 mM	0.4957 mL	2.4784 mL	4.9569 mL	24.7844 mL
10 mM	0.2478 mL	1.2392 mL	2.4784 mL	12.3922 mL
20 mM	0.1239 mL	0.6196 mL	1.2392 mL	6.1961 mL
50 mM	0.0496 mL	0.2478 mL	0.4957 mL	2.4784 mL
100 mM	0.0248 mL	0.1239 mL	0.2478 mL	1.2392 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc