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CC-115 hydrochloride

Catalog No. T61505 CAS 1300118-55-1

CC-115 hydrochloride is a potent dual inhibitor of DNA-PK and mTOR kinase, exhibiting IC50 values of 13 nM and 21 nM, respectively. It effectively blocks both mTORC1 and mTORC2 signaling pathways.

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CC-115 hydrochloride, CAS 1300118-55-1

Pack Size	Availability	Price/USD	Quantity
500 mg	6-8 weeks	$ 1,657.00

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This compound is a customized synthesis product. We have a strong synthesis team with excellent synthesis technology and capabilities. However, due to various objective factors, there is a low probability that the synthesis will not be successful. If you need to learn more, please feel free to consult us, we will serve you wholeheartedly.

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Description	CC-115 hydrochloride is a potent dual inhibitor of DNA-PK and mTOR kinase, exhibiting IC50 values of 13 nM and 21 nM, respectively. It effectively blocks both mTORC1 and mTORC2 signaling pathways.
In vitro	CC-115 effectively inhibits the proliferation of PC-3 cells with an IC50 value of 138 nM. In kinase selectivity screenings at 3 μM against 250 protein kinases, it significantly inhibits only mTOR kinase and one other kinase, cFMS, by 57% (IC50 = 2.0 μM). Among the tested PI3K-related kinases (PIKKs), CC-115 shows equipotency to DNA PK with an IC50 of 15 nM, demonstrating a selectivity range of 40 to >1000 fold over other PIKKs such as PI3K-alpha (IC50 = 0.85 μM), ATR (50% inhibition at 30 μM), and ATM (IC50 >30 μM). Furthermore, CC-115 displays minimal inhibitory activity against CYP enzymes and the hERG ion channel with IC50 values exceeding 10 μM and 33 μM, respectively. In a screening against a Cerep receptor and enzyme panel at 10 μM, CC-115 notably inhibits only one target, PDE3, by more than 50% (IC50 = 0.63 μM) [1].
In vivo	CC-115 hydrochloride demonstrates favorable pharmacokinetic (PK) profiles in vivo across multiple species, achieving oral bioavailability rates of 53%, 76%, and approximately 100% in mice, rats, and dogs, respectively. When administered at doses of 0.25, 0.5, and 1 mg/kg twice daily (bid) or at a single daily dose (qd) of 1 mg/kg, CC-115 leads to notable tumor volume reductions of 46%, 57%, 66%, and 57%, respectively. The compound maintains its inhibitory effect for 24 hours, with significant activity noted at 1 and 3 hours post-administration at a 1 mg/kg dose, and continuous inhibition observable up to 10 hours. CC-115 has been assessed under both once daily (qd) and twice daily (bid) dosing regimens.

Molecular Weight	372.82
Formula	C16H17ClN8O
CAS No.	1300118-55-1

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Powder: -20°C for 3 years | In solvent: -80°C for 1 year

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CC-115 hydrochloride 1300118-55-1 inhibitor inhibit

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