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L-AP4 monohydrate
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Catalog No. T37127Cas No. 2247534-79-6
Alias L-AP4 monohydrate
L-AP4 (L-APB) monohydrate is a potent and specific agonist for group III mGluRs, with EC50s of 0.13, 0.29, 1.0, and 249 μM for mGlu4, mGlu8, mGlu6, and mGlu7 receptors, respectively [1][2].
L-AP4 monohydrate
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Catalog No. T37127Alias L-AP4 monohydrateCas No. 2247534-79-6
L-AP4 (L-APB) monohydrate is a potent and specific agonist for group III mGluRs, with EC50s of 0.13, 0.29, 1.0, and 249 μM for mGlu4, mGlu8, mGlu6, and mGlu7 receptors, respectively [1][2].
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 25 mg | Inquiry | 6-8 weeks | 6-8 weeks | |
| 50 mg | Inquiry | 6-8 weeks | 6-8 weeks | |
| 100 mg | Inquiry | 6-8 weeks | 6-8 weeks |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Product Introduction
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | L-AP4 (L-APB) monohydrate is a potent and specific agonist for group III mGluRs, with EC50s of 0.13, 0.29, 1.0, and 249 μM for mGlu4, mGlu8, mGlu6, and mGlu7 receptors, respectively [1][2]. |
| Targets&IC50 | mGlu6:1.0 μM (EC50), mGlu4:0.13 μM (EC50), mGlu8:0.29 μM (EC50), mGlu7:249 μM (EC50) |
| In vivo | Intrathecal injection of L-AP4 (5-30 μg) over 4-5 days notably enhances the paw withdrawal threshold in response to von Frey filament application in eight nerve-ligated rats, demonstrating a dose-dependent effect. This treatment does not lead to any observable motor dysfunction. Furthermore, a specific dose of 30 μg L-AP4 does not significantly change paw withdrawal latency in normal rats. Additionally, the topical application of 5 to 50 μM L-AP4 directly to the spinal cord markedly reduces the neuronal response to sensory stimuli such as touch, pressure, pinch, and von Frey filaments in a concentration-dependent manner. The experiments were conducted using rat models. |
| Synonyms | L-AP4 monohydrate |
| Molecular Weight | 201.115 |
| Formula | C4H12NO6P |
| Cas No. | 2247534-79-6 |
| Smiles | O.N[C@@H](CCP(O)(O)=O)C(O)=O |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
Dose Conversion
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Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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