L-AP4 monohydrate

Name: L-AP4 monohydrate
Brand: TargetMol
SKU: T37127
Rating: 4.5 (1 reviews)

(Synonyms: L-AP4 monohydrate) Copy Product Info

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Synonyms: L-AP4 monohydrate

Catalog No. T37127 Copy Product Info

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L-AP4 (L-APB) monohydrate is a potent and specific agonist for group III mGluRs, with EC50s of 0.13, 0.29, 1.0, and 249 μM for mGlu4, mGlu8, mGlu6, and mGlu7 receptors, respectively [1][2].

Cas No. 2247534-79-6

Pack Size	Price	USA Stock	Global Stock
25 mg	Inquiry	6-8 weeks	6-8 weeks
50 mg	Inquiry	6-8 weeks	6-8 weeks
100 mg	Inquiry	6-8 weeks	6-8 weeks

For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)

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Bioactivity

Description	L-AP4 (L-APB) monohydrate is a potent and specific agonist for group III mGluRs, with EC50s of 0.13, 0.29, 1.0, and 249 μM for mGlu4, mGlu8, mGlu6, and mGlu7 receptors, respectively [1][2].
Targets & IC50	mGlu6:1.0 μM (EC50), mGlu4:0.13 μM (EC50), mGlu7:249 μM (EC50), mGlu8:0.29 μM (EC50)
In vivo	Intrathecal injection of L-AP4 (5-30 μg) over 4-5 days notably enhances the paw withdrawal threshold in response to von Frey filament application in eight nerve-ligated rats, demonstrating a dose-dependent effect. This treatment does not lead to any observable motor dysfunction. Furthermore, a specific dose of 30 μg L-AP4 does not significantly change paw withdrawal latency in normal rats. Additionally, the topical application of 5 to 50 μM L-AP4 directly to the spinal cord markedly reduces the neuronal response to sensory stimuli such as touch, pressure, pinch, and von Frey filaments in a concentration-dependent manner. The experiments were conducted using rat models.
Synonyms	L-AP4 monohydrate

Chemical Properties

Molecular Weight	201.115
Formula	C₄H₁₂NO₆P
Cas No.	2247534-79-6
Smiles	O.N[C@@H](CCP(O)(O)=O)C(O)=O

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 µL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 µL Tween 80 and mix well until fully clarified.

3) Add 450 µL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

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