Pelcitoclax

Name: Pelcitoclax
Brand: TargetMol
SKU: T36901
Rating: 4.5 (1 reviews)

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Catalog No. T36901Cas No. 1619923-36-2

Pelcitoclax (APG-1252) is a potent inhibitor of Bcl-2 and Bcl-xl proteins, demonstrating substantial antineoplastic and pro-apoptotic activities[1].

Pelcitoclax

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Catalog No. T36901Cas No. 1619923-36-2

Pelcitoclax (APG-1252) is a potent inhibitor of Bcl-2 and Bcl-xl proteins, demonstrating substantial antineoplastic and pro-apoptotic activities[1].

Pack Size	Price	Availability
5 mg	$2,389	8-10 weeks
10 mg	$3,819	8-10 weeks
25 mg	$5,728	8-10 weeks
50 mg	$7,458	8-10 weeks

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This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products. However, due to objective factors, there is a small probability that the synthesis may not be successful during the R&D process. We appreciate your understanding. If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.

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Product Introduction

Bioactivity

Description	Pelcitoclax (APG-1252) is a potent inhibitor of Bcl-2 and Bcl-xl proteins, demonstrating substantial antineoplastic and pro-apoptotic activities[1].
In vitro	APG-1252 undergoes metabolic transformation into its reactive form, APG-1252-M1, which exhibits significant antitumor activity in (acute myeloid leukemia)[1].
In vivo	Pelcitoclax (APG-1252; 25-100 mg/kg; i.v.; once daily for 10 days) treatment shows significantly greater inhibition of xenograft tumor growth compared to other groups[1].

Chemical Properties

Molecular Weight	1281.84
Formula	C₅₇H₆₆ClF₄N₆O₁₁PS₄
Cas No.	1619923-36-2

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc