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HRO761

Name: HRO761
Brand: TargetMol
SKU: T72107
Price: 55 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T72107Cas No. 2869954-34-5

Alias Werner syndrome RecQ helicase-IN-1, HRO-761

HRO761 is a potent Werne r syndrome RecQ DNA deconjugase (WRN) inhibitor that can be used to study cancers such as colon and stomach cancer.

HRO761

🥰Excellent

Purity: 99.62%

Catalog No. T72107Alias Werner syndrome RecQ helicase-IN-1, HRO-761Cas No. 2869954-34-5

HRO761 is a potent Werne r syndrome RecQ DNA deconjugase (WRN) inhibitor that can be used to study cancers such as colon and stomach cancer.

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$55	In Stock	In Stock
5 mg	$127	In Stock	In Stock
10 mg	$186	In Stock	In Stock
25 mg	$312	In Stock	In Stock
50 mg	$528	In Stock	In Stock
100 mg	$846	-	In Stock
500 mg	$1,890	-	In Stock
1 mL x 10 mM (in DMSO)	$865	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.62%

Resource Download

COA HPLC HNMR

Product Introduction

Bioactivity

Description	HRO761 is a potent Werne r syndrome RecQ DNA deconjugase (WRN) inhibitor that can be used to study cancers such as colon and stomach cancer.
Targets&IC50	WRN ATPase:100 nM, DLD1 WRN-KO cells:> 10 μM, SW48 cells:50 nM
In vitro	HRO761 exhibits an IC50 value of 100 nM for WRN ATPase, and demonstrates GI50 values of 50 nM and >10 μM for SW48 and DLD1 WRN-KO cell lines, respectively.[1]
Synonyms	Werner syndrome RecQ helicase-IN-1, HRO-761

Chemical Properties

Molecular Weight	702.08
Formula	C₃₁H₃₁ClF₃N₉O₅
Cas No.	2869954-34-5
Smiles	C(C(NC1=C(Cl)C=C(C(F)(F)F)C=C1)=O)N2C=3N(C(=O)C(=C2CC)N4CCN(C(=O)C=5C(O)=C(C)N=CN5)CC4)N=C(N3)C=6CCOCC6

Storage & Solubility Information

Storage

store at low temperature,keep away from direct sunlight,keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 99.7 mg/mL (142.01 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 3.3 mg/mL (4.7 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.4243 mL	7.1217 mL	14.2434 mL	71.2170 mL
5 mM	0.2849 mL	1.4243 mL	2.8487 mL	14.2434 mL
10 mM	0.1424 mL	0.7122 mL	1.4243 mL	7.1217 mL
20 mM	0.0712 mL	0.3561 mL	0.7122 mL	3.5608 mL
50 mM	0.0285 mL	0.1424 mL	0.2849 mL	1.4243 mL
100 mM	0.0142 mL	0.0712 mL	0.1424 mL	0.7122 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc