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HRO761

Name: HRO761
Brand: TargetMol
SKU: T72107
Price: 55 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T72107Cas No. 2869954-34-5

Alias Werner syndrome RecQ helicase-IN-1, HRO-761

HRO761 is a potent Werne r syndrome RecQ DNA deconjugase (WRN) inhibitor that can be used to study cancers such as colon and stomach cancer.

HRO761

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Purity: 99.62%

Catalog No. T72107Alias Werner syndrome RecQ helicase-IN-1, HRO-761Cas No. 2869954-34-5

HRO761 is a potent Werne r syndrome RecQ DNA deconjugase (WRN) inhibitor that can be used to study cancers such as colon and stomach cancer.

Pack Size	Price	Availability
1 mg	$55	In Stock
5 mg	$127	In Stock
10 mg	$186	In Stock
25 mg	$312	In Stock
50 mg	$528	In Stock
100 mg	$846	In Stock
500 mg	$1,890	In Stock
1 mL x 10 mM (in DMSO)	$865	In Stock

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Batch Information

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Purity:99.62%

Resource Download

COA HNMR HPLC

Product Introduction

Bioactivity

Description	HRO761 is a potent Werne r syndrome RecQ DNA deconjugase (WRN) inhibitor that can be used to study cancers such as colon and stomach cancer.
Targets&IC50	WRN ATPase:100 nM, DLD1 WRN-KO cells:> 10 μM, SW48 cells:50 nM
In vitro	HRO761 exhibits an IC50 value of 100 nM for WRN ATPase, and demonstrates GI50 values of 50 nM and >10 μM for SW48 and DLD1 WRN-KO cell lines, respectively.[1]
Synonyms	Werner syndrome RecQ helicase-IN-1, HRO-761

Chemical Properties

Molecular Weight	702.08
Formula	C₃₁H₃₁ClF₃N₉O₅
Cas No.	2869954-34-5
Smiles	C(C(NC1=C(Cl)C=C(C(F)(F)F)C=C1)=O)N2C=3N(C(=O)C(=C2CC)N4CCN(C(=O)C=5C(O)=C(C)N=CN5)CC4)N=C(N3)C=6CCOCC6

Storage & Solubility Information

Storage

store at low temperature,keep away from direct sunlight,keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 99.7 mg/mL (142.01 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.4243 mL	7.1217 mL	14.2434 mL	71.2170 mL
5 mM	0.2849 mL	1.4243 mL	2.8487 mL	14.2434 mL
10 mM	0.1424 mL	0.7122 mL	1.4243 mL	7.1217 mL
20 mM	0.0712 mL	0.3561 mL	0.7122 mL	3.5608 mL
50 mM	0.0285 mL	0.1424 mL	0.2849 mL	1.4243 mL
100 mM	0.0142 mL	0.0712 mL	0.1424 mL	0.7122 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc