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AT-007

🥰Excellent
Catalog No. T10393Cas No. 2170729-29-8

AT-007 is an orally active CNS penetrant Aldose Reductase inhibitor for the treatment of Galactosemia (IC50: 100 pM). It reduces toxic galactitol levels and prevents disease complications in GALT deficiency rats.

AT-007

AT-007

🥰Excellent
Purity: 99.36%
Catalog No. T10393Cas No. 2170729-29-8
AT-007 is an orally active CNS penetrant Aldose Reductase inhibitor for the treatment of Galactosemia (IC50: 100 pM). It reduces toxic galactitol levels and prevents disease complications in GALT deficiency rats.
Pack SizePriceAvailabilityQuantity
1 mg$50In Stock
5 mg$113In Stock
10 mg$189In Stock
25 mg$347In Stock
50 mg$562In Stock
100 mg$783In Stock
1 mL x 10 mM (in DMSO)$126In Stock
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Purity:99.36%
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COA HPLC HNMR

Product Introduction

Bioactivity
Description
AT-007 is an orally active CNS penetrant Aldose Reductase inhibitor for the treatment of Galactosemia (IC50: 100 pM). It reduces toxic galactitol levels and prevents disease complications in GALT deficiency rats.
Targets&IC50
Aldose reductase:100 pM
In vivo
AT-007 markedly reduces galactitol levels across all target tissues (liver, brain, and plasma) in GALT null rats, without elevating galactose or Gal-1P concentrations [2].
Chemical Properties
Molecular Weight425.4
FormulaC17H10F3N3O3S2
Cas No.2170729-29-8
SmilesOC(=O)Cc1nn(Cc2nc3cc(ccc3s2)C(F)(F)F)c(=O)c2cscc12
Relative Density.1.72 g/cm3 (Predicted)
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
DMSO: 35.71 mg/mL (83.94 mM), Sonication is recommended.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM2.3507 mL11.7536 mL23.5073 mL117.5364 mL
5 mM0.4701 mL2.3507 mL4.7015 mL23.5073 mL
10 mM0.2351 mL1.1754 mL2.3507 mL11.7536 mL
20 mM0.1175 mL0.5877 mL1.1754 mL5.8768 mL
50 mM0.0470 mL0.2351 mL0.4701 mL2.3507 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.
1 Enter information below:
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2 Enter the in vivo formulation:
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

InhibitorinhibitAT-007AT007AT 007Aldose Reductase
Related Tags: buy AT-007 | purchase AT-007 | AT-007 cost | order AT-007 | AT-007 chemical structure | AT-007 in vivo | AT-007 formula | AT-007 molecular weight
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