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Dextran sulfate sodium salt (MW 5000)
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Catalog No. T13647Cas No. 9011-18-1
Alias DSS, Dextran sulfate sodium salt (MW 5000)
Dextran sulfate sodium salt (MW 4500-5500) is a polymer of dehydrated glucose and an inhibitor of complement and coagulation pathways. Dextran sulfate sodium salt (MW 4500-5500) can be used as an anticoagulant, antiviral agent and antilipidemic agent. Dextran sulfate sodium salt (MW 4500-5500) can prevent the HIV-1 virus from adsorbing onto host cells. Dextran sulfate sodium salt (MW 4500-5500) can inhibit NK cell-mediated cytotoxicity. Dextran sulfate sodium salt (MW 4500-5500) can inhibit the immediate blood-mediated inflammatory response (IBMIR).
Dextran sulfate sodium salt (MW 5000)
Copy Product Info😃Good
Catalog No. T13647Alias DSS, Dextran sulfate sodium salt (MW 5000)Cas No. 9011-18-1
Dextran sulfate sodium salt (MW 4500-5500) is a polymer of dehydrated glucose and an inhibitor of complement and coagulation pathways. Dextran sulfate sodium salt (MW 4500-5500) can be used as an anticoagulant, antiviral agent and antilipidemic agent. Dextran sulfate sodium salt (MW 4500-5500) can prevent the HIV-1 virus from adsorbing onto host cells. Dextran sulfate sodium salt (MW 4500-5500) can inhibit NK cell-mediated cytotoxicity. Dextran sulfate sodium salt (MW 4500-5500) can inhibit the immediate blood-mediated inflammatory response (IBMIR).
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 10 g | $40 | - | In Stock | |
| 25 g | $81 | - | In Stock | |
| 50 g | $128 | - | In Stock |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Color:White
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| Description | Dextran sulfate sodium salt (MW 4500-5500) is a polymer of dehydrated glucose and an inhibitor of complement and coagulation pathways. Dextran sulfate sodium salt (MW 4500-5500) can be used as an anticoagulant, antiviral agent and antilipidemic agent. Dextran sulfate sodium salt (MW 4500-5500) can prevent the HIV-1 virus from adsorbing onto host cells. Dextran sulfate sodium salt (MW 4500-5500) can inhibit NK cell-mediated cytotoxicity. Dextran sulfate sodium salt (MW 4500-5500) can inhibit the immediate blood-mediated inflammatory response (IBMIR). |
| Targets&IC50 | HIV-1:9.1 µg/mL |
| In vitro | METHODS: MT-4 cells were treated with Dextran sulfate sodium salt (MW 4500-5500) (25 μg/mL) for 24 hours. The inhibitory effect on HIV-1 replication was observed, and the effects of the drug on cytotoxicity and reverse transcriptase activity were evaluated. RESULTS: Dextran sulfate sodium salt (MW 4500-5500) has a significant selective inhibitory effect on HIV-1, with an IC50 value of 2.3-8.8 µg/ml, and does not show toxicity to host cells at high concentrations. [1] |
| In vivo | METHODS: To investigate the effect of Dextran sulfate sodium salt (MW 4500-5500) on endothelial injury after ischemia and reperfusion in a rat model of inferior renal aortic clamp, Dextran sulfate sodium salt (MW 4500-5500)(5 mg/mL, 200 μL) was immediately locally infused into the ischemic aortic segment of rats before reperfusion. RESULTS: Dextran sulfate sodium salt (MW 4500-5500) inhibits complement activation and reduces endothelial injury after ischemia and reperfusion in the rat model of inferior renal aortic clamp. [2] |
| Synonyms | DSS, Dextran sulfate sodium salt (MW 5000) |
| Molecular Weight | 9000-20000 |
| Formula | (C6H7Na3O14S3)n |
| Cas No. | 9011-18-1 |
| Relative Density. | no data available |
| Storage | In solvent: -80°C for 1 year |
| Solubility Information | H2O: 100 mg/mL, Sonication is recommended.  DMSO: Insoluble |
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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