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Dextran sulfate sodium salt (MW 5000)
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Catalog No. T13647Cas No. 9011-18-1
Alias DSS, Dextran sulfate sodium salt (MW 5000)
Dextran sulfate sodium salt (MW 4500-5500) is a polymer of dehydrated glucose and an inhibitor of complement and coagulation pathways. Dextran sulfate sodium salt (MW 4500-5500) can be used as an anticoagulant, antiviral agent and antilipidemic agent. Dextran sulfate sodium salt (MW 4500-5500) can prevent the HIV-1 virus from adsorbing onto host cells. Dextran sulfate sodium salt (MW 4500-5500) can inhibit NK cell-mediated cytotoxicity. Dextran sulfate sodium salt (MW 4500-5500) can inhibit the immediate blood-mediated inflammatory response (IBMIR).
Dextran sulfate sodium salt (MW 5000)
😃Good
Catalog No. T13647Alias DSS, Dextran sulfate sodium salt (MW 5000)Cas No. 9011-18-1
Dextran sulfate sodium salt (MW 4500-5500) is a polymer of dehydrated glucose and an inhibitor of complement and coagulation pathways. Dextran sulfate sodium salt (MW 4500-5500) can be used as an anticoagulant, antiviral agent and antilipidemic agent. Dextran sulfate sodium salt (MW 4500-5500) can prevent the HIV-1 virus from adsorbing onto host cells. Dextran sulfate sodium salt (MW 4500-5500) can inhibit NK cell-mediated cytotoxicity. Dextran sulfate sodium salt (MW 4500-5500) can inhibit the immediate blood-mediated inflammatory response (IBMIR).
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 g | $31 | In Stock | |
| 5 g | $81 | In Stock | |
| 10 g | $118 | In Stock | |
| 25 g | $198 | Backorder |
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Chemical Properties
| Description | Dextran sulfate sodium salt (MW 4500-5500) is a polymer of dehydrated glucose and an inhibitor of complement and coagulation pathways. Dextran sulfate sodium salt (MW 4500-5500) can be used as an anticoagulant, antiviral agent and antilipidemic agent. Dextran sulfate sodium salt (MW 4500-5500) can prevent the HIV-1 virus from adsorbing onto host cells. Dextran sulfate sodium salt (MW 4500-5500) can inhibit NK cell-mediated cytotoxicity. Dextran sulfate sodium salt (MW 4500-5500) can inhibit the immediate blood-mediated inflammatory response (IBMIR). |
| Targets&IC50 | HIV-1:9.1 µg/mL |
| In vitro | METHODS: MT-4 cells were treated with Dextran sulfate sodium salt (MW 4500-5500) (25 μg/mL) for 24 hours. The inhibitory effect on HIV-1 replication was observed, and the effects of the drug on cytotoxicity and reverse transcriptase activity were evaluated. RESULTS: Dextran sulfate sodium salt (MW 4500-5500) has a significant selective inhibitory effect on HIV-1, with an IC50 value of 2.3-8.8 µg/ml, and does not show toxicity to host cells at high concentrations. [1] |
| In vivo | METHODS: To investigate the effect of Dextran sulfate sodium salt (MW 4500-5500) on endothelial injury after ischemia and reperfusion in a rat model of inferior renal aortic clamp, Dextran sulfate sodium salt (MW 4500-5500)(5 mg/mL, 200 μL) was immediately locally infused into the ischemic aortic segment of rats before reperfusion. RESULTS: Dextran sulfate sodium salt (MW 4500-5500) inhibits complement activation and reduces endothelial injury after ischemia and reperfusion in the rat model of inferior renal aortic clamp. [2] |
| Synonyms | DSS, Dextran sulfate sodium salt (MW 5000) |
| Molecular Weight | 9000-20000 |
| Formula | (C6H7Na3O14S3)n |
| Cas No. | 9011-18-1 |
| Relative Density. | no data available |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | H2O: 80 mg/mL DMSO: Insoluble  |
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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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