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Dextran sulfate sodium salt (MW 5000)

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Catalog No. T13647Cas No. 9011-18-1
Alias DSS, Dextran sulfate sodium salt (MW 5000)

Dextran sulfate sodium salt (MW 5000) can inhibit human immunodeficiency virus (HIV) replication by preventing viral adsorption to host cells and primarily induces inflammation in the colon. Its sulfate groups confer a high negative charge that disrupts the integrity of the intestinal mucosal barrier, leading to barrier damage, macrophage dysfunction, and microbiota imbalance. It is commonly used to induce inflammatory bowel disease (IBD) models.

Dextran sulfate sodium salt (MW 5000)

Dextran sulfate sodium salt (MW 5000)

😃Good
Catalog No. T13647Alias DSS, Dextran sulfate sodium salt (MW 5000)Cas No. 9011-18-1
Dextran sulfate sodium salt (MW 5000) can inhibit human immunodeficiency virus (HIV) replication by preventing viral adsorption to host cells and primarily induces inflammation in the colon. Its sulfate groups confer a high negative charge that disrupts the integrity of the intestinal mucosal barrier, leading to barrier damage, macrophage dysfunction, and microbiota imbalance. It is commonly used to induce inflammatory bowel disease (IBD) models.
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1 g$31In Stock
5 g$81In Stock
10 g$118In Stock
25 g$198Backorder
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Bioactivity
Description
Dextran sulfate sodium salt (MW 5000) can inhibit human immunodeficiency virus (HIV) replication by preventing viral adsorption to host cells and primarily induces inflammation in the colon. Its sulfate groups confer a high negative charge that disrupts the integrity of the intestinal mucosal barrier, leading to barrier damage, macrophage dysfunction, and microbiota imbalance. It is commonly used to induce inflammatory bowel disease (IBD) models.
Targets&IC50
HIV-1:9.1 µg/mL
In vitro
Method: Dextran Sulfate Sodium Salt (MW 5000) was studied for its antiviral activity against human immunodeficiency virus type 1 (HIV-1) and its mechanism of action. MT-4 cells were exposed to different concentrations of DSS and heparin to observe their inhibitory effects on HIV-1 replication. Additionally, the cytotoxicity and impact on reverse transcriptase activity were evaluated. Results: DSS exhibited a significant selective inhibitory effect on HIV-1, with an IC50 value of 9.1 µg/ml, and showed no toxicity to host cells even at high concentrations.
AliasDSS, Dextran sulfate sodium salt (MW 5000)
Chemical Properties
Molecular Weight9000-20000
Formula(C6H7Na3O14S3)n
Cas No.9011-18-1
Relative Density.no data available
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
H2O: 80 mg/mL
DMSO: Insoluble

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Keywords

HIVProteaseHIV ProteaseHIVDextran sulfate sodium salt (MW 45005500)Dextran sulfate sodium salt (MW 4500 5500)Dextran sulfate sodiumApoptosis
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