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Glucosamine

Name: Glucosamine
Brand: TargetMol
SKU: T0429
Price: 50 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T0429Cas No. 3416-24-8

Alias D-Glucosamine, Chitosamine

Glucosamine (Chitosamine) is a natural product. Glucosamine is used as a dietary supplement. Glucosamine has pharmacological effects on cartilage and chondrocytes in osteoarthritis when used externally. Glucosamine regulates sugar metabolism. Glucosamine reduces the activity of glucoskinase in pancreatic islet homogenate.

Glucosamine

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Purity: 99.8%

Catalog No. T0429Alias D-Glucosamine, ChitosamineCas No. 3416-24-8

Pack Size	Price	Availability	Quantity
50 mg	$50	In Stock
1 mL x 10 mM (in DMSO)	$50	In Stock

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Purity:99.8%

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COA HNMR LCMS

Product Introduction

Bioactivity

Description	Glucosamine (Chitosamine) is a natural product. Glucosamine is used as a dietary supplement. Glucosamine has pharmacological effects on cartilage and chondrocytes in osteoarthritis when used externally. Glucosamine regulates sugar metabolism. Glucosamine reduces the activity of glucoskinase in pancreatic islet homogenate.
Targets&IC50	superoxide:47.67 mM (IC20), DPPH:21.32 mM, hydroxyl:14.04 mM
In vitro	METHODS: YD-8 human tongue cancer cells were treated with Glucosamine (10 mM) for 4 hours, and the phosphorylation levels of related proteins were detected by western blot. RESULTS: Glucosamine inhibits HIF-1α and reduces the phosphorylation of p70S6K and S6 translation-related proteins. [1] METHODS: Renal cells were treated with Glucosamine (5 mM) for 12, 24 and 36 hours, and the expression level of target proteins was detected by western blot. RESULTS: Glucosamine significantly reduced the renal expressions of α -smooth muscle actin, collagen I and fibronectin in obstructive kidneys and renal cells treated with TGF-β1. [2]
In vivo	METHODS: To study the effect of Glucosamine on bone injury, Glucosamine (20 mg/kg/day) was orally administered to mice for 30 consecutive days. RESULTS: Glucosamine significantly reduces cartilage damage and osteophyte formation. [3]
Synonyms	D-Glucosamine, Chitosamine

Chemical Properties

Molecular Weight	179.17
Formula	C₆H₁₃NO₅
Cas No.	3416-24-8
Smiles	N[C@@H](C=O)[C@@H](O)[C@H](O)[C@H](O)CO
Relative Density.	1.563 g/cm3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

H2O: 200.9 mM, Sonication is recommended.

DMSO: 58 mg/mL (323.71 mM), Sonication is recommended.

Solution Preparation Table

H2O/DMSO

	1mg	5mg	10mg	50mg
1 mM	5.5813 mL	27.9065 mL	55.8129 mL	279.0646 mL
5 mM	1.1163 mL	5.5813 mL	11.1626 mL	55.8129 mL
10 mM	0.5581 mL	2.7906 mL	5.5813 mL	27.9065 mL
20 mM	0.2791 mL	1.3953 mL	2.7906 mL	13.9532 mL
50 mM	0.1116 mL	0.5581 mL	1.1163 mL	5.5813 mL
100 mM	0.0558 mL	0.2791 mL	0.5581 mL	2.7906 mL

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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

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DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

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