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Glucosamine
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Catalog No. T0429Cas No. 3416-24-8
Alias D-Glucosamine, Chitosamine
Glucosamine (Chitosamine) is a natural product. Glucosamine is used as a dietary supplement. Glucosamine has pharmacological effects on cartilage and chondrocytes in osteoarthritis when used externally. Glucosamine regulates sugar metabolism. Glucosamine reduces the activity of glucoskinase in pancreatic islet homogenate.
Glucosamine
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Purity: 99.8%
Catalog No. T0429Alias D-Glucosamine, ChitosamineCas No. 3416-24-8
Glucosamine (Chitosamine) is a natural product. Glucosamine is used as a dietary supplement. Glucosamine has pharmacological effects on cartilage and chondrocytes in osteoarthritis when used externally. Glucosamine regulates sugar metabolism. Glucosamine reduces the activity of glucoskinase in pancreatic islet homogenate.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 50 mg | $50 | In Stock | In Stock | |
| 1 mL x 10 mM (in DMSO) | $50 | In Stock | In Stock |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Purity:99.8%
Color:White
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Product Introduction
Glucosamine AI Summary
Glucosamine shows a binding affinity for the 16S ribosomal RNA A-site of Escherichia coli, with a Kd value of approximately 1000000.0 nM. It has demonstrated various biological activities in different assays. In rat studies, it affected plasma GPT and GOT levels, and altered concentrations of several ceramides in plasma and liver tissues, indicating potential impacts on liver function and lipid metabolism. It also increased plasma and hepatic vitamin C levels in Wistar rats when administered intraperitoneally at 1 g/kg, with effects observed over 24 hours.
The compound exhibited anti-inflammatory activity in carrageenan-induced paw edema and antiarthritic activity in a Mycobacterium tuberculosis-induced rat arthritic model, with notable reduction at 250 mg/kg. In human OCT1 studies, it inhibited the uptake of 4-(4-(dimethylamino)styryl)-N-methylpyridinium at 100 uM. In bovine articular cartilage explants, it reduced IL1-induced glycosaminoglycan release and showed cytotoxicity against bovine chondrocytes at various concentrations.
Furthermore, Glucosamine exhibited antifungal activity by inhibiting mycelial growth of Poria placenta FPRL 280 and Trametes versicolor Quel. CTB 863-A at specified concentrations. It induced the activity of Heparan-alpha-glucosaminide N-acetyltransferase N273K mutant in skin fibroblasts at 14 mM concentration. However, in anti-viral activity assays against SARS-CoV-2, it showed a low hit score of 0.1709. The compound also inhibited the binding affinity to V5-His tagged FIBCD1 ecto-domain at 50 mM. Despite these varied effects, Glucosamine showed no significant bioactivity in multiple receptor and enzyme assays, with AC50 values exceeding 30000.0 nM..
Note: Summary generated by AI. Data source: ChEMBL 
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | Glucosamine (Chitosamine) is a natural product. Glucosamine is used as a dietary supplement. Glucosamine has pharmacological effects on cartilage and chondrocytes in osteoarthritis when used externally. Glucosamine regulates sugar metabolism. Glucosamine reduces the activity of glucoskinase in pancreatic islet homogenate. |
| Targets&IC50 | superoxide:47.67 mM (IC20), hydroxyl:14.04 mM, DPPH:21.32 mM |
| In vitro | METHODS: YD-8 human tongue cancer cells were treated with Glucosamine (10 mM) for 4 hours, and the phosphorylation levels of related proteins were detected by western blot. RESULTS: Glucosamine inhibits HIF-1α and reduces the phosphorylation of p70S6K and S6 translation-related proteins. [1] METHODS: Renal cells were treated with Glucosamine (5 mM) for 12, 24 and 36 hours, and the expression level of target proteins was detected by western blot. RESULTS: Glucosamine significantly reduced the renal expressions of α -smooth muscle actin, collagen I and fibronectin in obstructive kidneys and renal cells treated with TGF-β1. [2] |
| In vivo | METHODS: To study the effect of Glucosamine on bone injury, Glucosamine (20 mg/kg/day) was orally administered to mice for 30 consecutive days. RESULTS: Glucosamine significantly reduces cartilage damage and osteophyte formation. [3] |
| Synonyms | D-Glucosamine, Chitosamine |
| Molecular Weight | 179.17 |
| Formula | C6H13NO5 |
| Cas No. | 3416-24-8 |
| Smiles | N[C@@H](C=O)[C@@H](O)[C@H](O)[C@H](O)CO |
| Relative Density. | 1.563 g/cm3 |
| Storage | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. | |||||||||||||||||||||||||||||||||||
| Solubility Information | H2O: 200.9 mM, Sonication is recommended. DMSO: 58 mg/mL (323.71 mM), Sonication is recommended.  | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
H2O/DMSO
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Calculator
In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
Dose Conversion
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Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
Keywords
TNF-αReactiveOxygenSpeciesReactive Oxygen SpeciesNF-κBNFκBNF-kBNFkBMMP-9InhibitorinhibitIFγHypoxia-inducible factorsHIFsHIFProlylHydroxylaseHIF-PHHIF/HIFProlylHydroxylaseHIF/HIF Prolyl-HydroxylaseHIF/HIF ProlylHydroxylaseHIF Prolyl-HydroxylaseHIF ProlylHydroxylaseHIFGlucosamineEndogenousMetaboliteEndogenous MetaboliteChitosanaseAutophagy
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