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VH032

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Purity:99.72%

ee:100%

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COA LCMS HPLC HNMR CSFC

VH032

Catalog No. T29106Cas No. 1448188-62-2

VH032 commonly used as a precursor to a PROTAC that hijacks VHL as the E3 ubiquitin ligase component.VH032 is a VHL/HIF-1α interaction inhibitor with a KdPROTACs, which can recruit von Hippel-Lindau (VHL) proteins as a ligand of VHL.

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Pack Size	Price/USD	Availability
1 mg	$44	In Stock
5 mg	$98	In Stock
10 mg	$163	In Stock
25 mg	$337	In Stock
50 mg	$533	In Stock
100 mg	$769	In Stock

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Product Introduction

Bioactivity

Description	VH032 commonly used as a precursor to a PROTAC that hijacks VHL as the E3 ubiquitin ligase component.VH032 is a VHL/HIF-1α interaction inhibitor with a KdPROTACs, which can recruit von Hippel-Lindau (VHL) proteins as a ligand of VHL.
Alias	VH-032, VH 032

Chemical Properties

Molecular Weight	472.6
Formula	C24H32N4O4S
Cas No.	1448188-62-2

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 90.0 mg/mL (190.4 mM)

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.1160 mL	10.5798 mL	21.1595 mL	105.7977 mL
5 mM	0.4232 mL	2.1160 mL	4.2319 mL	21.1595 mL
10 mM	0.2116 mL	1.0580 mL	2.1160 mL	10.5798 mL
20 mM	0.1058 mL	0.5290 mL	1.0580 mL	5.2899 mL
50 mM	0.0423 mL	0.2116 mL	0.4232 mL	2.1160 mL
100 mM	0.0212 mL	0.1058 mL	0.2116 mL	1.0580 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg,each TargetMol | Animal experiments

animal weighs 20 g, and the dosage volume is 100 μL. A total of TargetMol | Animal experiments

10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL.

Mother liquor preparation method: 2 mg of drug dissolved in 50 μLDMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μLDMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μLTween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify.

Dose Conversion

You can also refer to dose conversion for different animals. More

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.