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VH032

Name: VH032
Brand: TargetMol
SKU: T29106
Price: 40 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T29106Cas No. 1448188-62-2

Alias VH-032, VH 032

VH032 commonly used as a precursor to a PROTAC that hijacks VHL as the E3 ubiquitin ligase component.VH032 is a VHL/HIF-1α interaction inhibitor with a KdPROTACs, which can recruit von Hippel-Lindau (VHL) proteins as a ligand of VHL.

VH032

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Purity: 99.72%

Catalog No. T29106Alias VH-032, VH 032Cas No. 1448188-62-2

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$40	In Stock	In Stock
2 mg	$55	In Stock	In Stock
5 mg	$88	In Stock	In Stock
10 mg	$147	In Stock	In Stock
25 mg	$280	In Stock	In Stock
50 mg	$410	In Stock	In Stock
100 mg	$575	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products.If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:99.72%

ee:100%

Appearance:Solid

Color:White

Resource Download

COA HPLC HNMR CSFC

Product Introduction

VH032 AI Summary

VH032 exhibits a significant binding affinity to N-terminal His6-tagged VHL (54 to 213 amino acids) with a dissociation constant (Kd) of 185.0 nM as assessed by isothermal titration calorimetry. It induces VHL-mediated TBK1 degradation in human Panc02.13 cells and inhibits the interaction between His-tagged VHL/elongin B/elongin C complex and HIF1alpha. The compound has a high binding affinity to the VBC complex with dissociation constants in the range of 100-200 nM and an IC50 value of 454.0 nM according to fluorescence polarization assays, indicating moderate potency. Additionally, VH032 demonstrates inhibitory activity on VBC in human HeLa cells and stabilizing activities on HIF-1 alpha with a logD/logP of 0.94 at pH 7.4. It also displays passive permeability, moderate hydrophobicity, and long half-life in plasma and liver microsomes, suggesting favorable pharmacokinetic properties..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	VH032 commonly used as a precursor to a PROTAC that hijacks VHL as the E3 ubiquitin ligase component.VH032 is a VHL/HIF-1α interaction inhibitor with a KdPROTACs, which can recruit von Hippel-Lindau (VHL) proteins as a ligand of VHL.
Synonyms	VH-032, VH 032

Chemical Properties

Molecular Weight	472.6
Formula	C₂₄H₃₂N₄O₄S
Cas No.	1448188-62-2
Smiles	CC(=O)N[C@H](C(=O)N1C[C@H](O)C[C@H]1C(=O)NCc1ccc(cc1)-c1scnc1C)C(C)(C)C
Relative Density.	1.248 g/cm3 (Predicted)

Storage & Solubility Information

Storage

In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 150 mg/mL (317.39 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 3.3 mg/mL (6.98 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.1160 mL	10.5798 mL	21.1595 mL	105.7977 mL
5 mM	0.4232 mL	2.1160 mL	4.2319 mL	21.1595 mL
10 mM	0.2116 mL	1.0580 mL	2.1160 mL	10.5798 mL
20 mM	0.1058 mL	0.5290 mL	1.0580 mL	5.2899 mL
50 mM	0.0423 mL	0.2116 mL	0.4232 mL	2.1160 mL
100 mM	0.0212 mL	0.1058 mL	0.2116 mL	1.0580 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc