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TargetMol | Tags GPCR/G Protein
TargetMol | Tags Neuroscience

Neurokinin receptor

The tachykinin receptor 1 (TACR1) also known as neurokinin 1 receptor (NK1R) or substance P receptor (SPR) is a G protein coupled receptor found in the central nervous system and peripheral nervous system. The endogenous ligand for this receptor is Substance P, although it has some affinity for other tachykinins.

  • Befetupitant
    T14524290296-68-3In house
    Befetupitant (Ro67-5930) is a potent and selective tachykinin 1 receptor (NK1R) antagonist for the study of corneal neovascularization.
    • $490
    In Stock
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  • [Sar9,Met(O2)11]-Substance P acetate
    TP1369L
    [Sar9,Met(O2)11]-Substance P acetate is a tachykinin NK1 receptor selective agonist. [Sar9,Met(O2)11]-Substance P acetate is a selective tachykinin NK1 receptor agonist.[Sar9,Met(O2)11]-Substance P acetate and septide (10-100 pmol per rat, i.c.v.) are equipotent in increasing mean arterial blood pressure (MAP) and heart rate (HR), yet they have dissimilar time-course. Both agonists increase dose-dependently face washing and sniffing while [Sar9,Met(O2)11]-Substance P acetate is the sole to produce grooming.
    • $92
    In Stock
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  • Spantide acetate
    T20413L
    Spantide acetate is a selective antagonist of NK1 receptor with Kis of 230 nM and 8150 nM for NK1 and NK2.
    • $131
    In Stock
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  • Eledoisin Related Peptide 2TFA
    T7631L
    Eledoisin Related Peptide 2TFA (Eledoisin Related Peptide 2TFA (2990-43-4(free base))) is a tachykinin receptor ligand.
    • $75
    In Stock
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  • C14TKL-1 acetate
    TP2227L
    C14TKL-1 acetate is a NK1 receptor agonist.
    • $133
    In Stock
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  • Rolapitant hydrochloride
    T3724858102-79-1
    Rolapitant (SCH619734) hydrochloride is a potent, selective, long-acting and orally active neurokinin 1 (NK1) receptor antagonist with a K i of 0.66 nM. Rolapitant hydrochloride (Rolapitant HCl) does not interact with CYP3A4. Rolapitant hydrochloride shows potent centrally-mediated anti-emetic activity in both acute and delayed ferret emesis models [1] [2].
    • $258
    In Stock
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    TargetMol | Citations Cited
  • WIN 51,708
    T29157144177-30-0In house
    WIN 51,708 is a neurokinin receptor (NK1) antagonist.
    • $293
    In Stock
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  • Lanepitant 2HCl
    T25616170508-05-1In house
    Lanepitant 2HCl is a non-peptide neurokinin-1 receptor antagonist with analgesic and anti-inflammatory activity.Lanepitant 2HCl inhibits the binding of Substance P to the neurokinin-1 receptor, inhibits neurogenic inflammation and pain transmission, and can be used in the study of painful neuropathic disorders, such as migraines.
    • $195 TargetMol
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  • Kassinin acetate(63968-82-1 free base)
    TP1738L
    Kassinin acetate is a peptide derived from the Kassina frog. It belongs to tachykinin family of neuropeptides.
    • $133
    In Stock
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  • Neurokinin A(4-10) TFA(97559-35-8 free base)
    TP1385
    Neurokinin A(4-10) TFA(97559-35-8 free base) is a tachykinin NK2 receptor agonist[1].
    • $68
    In Stock
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  • MEN 10207 acetate
    T24446L
    MEN 10207 acetate is a selective antagonist for NK-2 tachykinin receptor.
    • $148
    In Stock
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  • Hemokinin 1 (mouse) acetate(208041-90-1 free base)
    TP1772L
    Hemokinin 1 (mouse) acetate is a selective excitogen 1 receptor agonist with a Ki value of 0.175 nM for the human NK1 receptor and 560 nM for the human NK2 receptor.
    • $143
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  • [Sar9] Substance P acetate(77128-75-7 free base)
    TP1862L
    [Sar9]-Substance P acetate is one of NK-1 receptor agonist. The action of SP on progesterone metabolism was mimicked by the rNK1-specific agonist [Sar-9,Met(O2)11]-SP.
    • $90
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  • Neurokinin B acetate(86933-75-7 free base)
    TP1363L
    Neurokinin B acetate(86933-75-7 free base) is the acetate form of Neurokinin B, which belongs to the tachykinin family. Neurokinin binds to neurokinin receptor 1 (NK1R), nk2r and NK3R, and mediates its biological effects.
    • $80
    In Stock
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  • R 396 acetate
    T24697L
    R 396 acetate is an NK-2 Tachykinin Receptor Antagonist.
    • $195
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  • Scyliorhinin II acetate
    TP1851L
    Scyliorhinin II acetate is a selective agonist of the neurokinin-3 (NK3) receptor (Ki = 2.5 nM) in rat cerebral cortex.
    • $113
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  • [Lys5,MeLeu9,Nle10]-NKA(4-10)
    TP1883137565-28-7
    Highy selective and potent NK2 receptor agonist (IC50 = 6.1 nM). Induces contraction of the rat fundus and bladder (EC50 values are 117 and 10 nM respectively).
    • $173
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  • Hemokinin 1 (human) acetate(491851-53-7 free base)
    TP1899L1
    Hemokinin 1 (human) acetate is an endogenous substance P homolog that is a selective agonist at the tachykinin NK1 receptor (IC50 values are 1.8, 370 and 480 nM for NK1, NK3 and NK2 receptors respectively). Has proliferative and antiapoptotic actions on B
    • $101
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  • (R)-CJ 11974
    T68068L187281-35-2In house
    (R)-CJ 11974 is a novel non-peptide neurokinin NK1 substance P receptor antagonist with potential analgesic activity that can be used to study chemotherapy-induced vomiting.
    • $195
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  • GR 94800 acetate
    T22811L
    GR 94800 acetate is a potent and selective neurokinin 2(NK-2) antagonist.
    • $636
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  • Burapitant
    T69140537034-22-3In house
    Burapitant (SSR 240600) is a novel non-peptide tachykinin neurokinin 1 (NK) receptor antagonist with anti-coke oven and antidepressant activity.
    • $988
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  • Men 10376 TFA(135306-85-3,free)
    TP1086
    Men 10376 TFA(135306-85-3,free) (Neurokinin-2 receptor antagonist TFA) is an effective and selective tachykinin nk-2 receptor antagonist with a K I value of 4.4 M for the nk-2 receptor in the small intestine of rats.
    • $181
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  • Physalaemin acetate
    T19518L
    Physalaemin acetate is a non-mammalian tachykinin with high affinity when binding selectively to neurokinin-1 (NK1) receptor.
    • $87
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  • NKP608
    TQ0087177707-12-9In house
    NKP608 is a selective and potent antagonist at the neurokinin-1 (NK-1) receptor both in vitro(IC50: 2.6 nM) and in vivo.
    • $152
    5 days
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  • Vofopitant dihydrochloride
    T13329L168266-51-1In house
    Vofopitant dihydrochloride (GR 205171A) is an orally available, selective tachykinin NK1 receptor antagonist that inhibits [3H]SP binding to NK1 with pKi values of 9.5 and 10.6, respectively.Vofopitant dihydrochloride is a potential compound for the treatment of pathological vomiting. Vofopitant dihydrochloride is a potential compound for the treatment of pathological vomiting.
    • $100
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  • Vofopitant
    T13329168266-90-8In house
    Vofopitant (GR 205171) is a potent NK1 receptor antagonist with anxiolytic and antiemetic activity for the study of post-traumatic stress disorder (PTSD).
    • $100
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  • Pavinetant
    T16114941690-55-7In house
    Pavinetant (MLE-4901) is an orally available neurokinin-3 receptor (NK3R) antagonist used to improve menopausal symptoms.
    • $74 TargetMol
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  • Fezolinetant
    T152781629229-37-3
    Fezolinetant (ESN-364) is an antagonist of the neurokinin 3 receptor (NK3R). It is used for the treatment of menopausal hot flushes.
    • $73
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    TargetMol | Citations Cited
  • Eledoisin Related Peptide
    T76312990-43-4
    Eledoisin Related Peptide (Eledoisin RP) is a tachykinin receptor ligand.
    • $155
    35 days
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  • Senktide acetate
    T7633L
    Senktide acetate (Senktide acetate(106128-89-6 free base)) is a selective tachykinin NK3 receptor agonist that promotes the consolidation or expression of ELM for the study of Alzheimer's disease.
    • $82
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  • Eledoisin
    TP117769-25-0
    Eledoisin (Eledone peptide) is a specific agonist of NK2 and NK3 receptors.Eledoisin is an undecapeptide of mollusk origin, belonging to the tachykinin family of neuropeptides.
    • $215
    35 days
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  • Substance P(1-7)
    T739668060-49-1
    Substance P(1-7) (Substance P 1-7) is the major bioactive metabolite formed after proteolytic degradation of the tachykinin substance P (SP),with anti-inflammatory, anti-nociceptive and anti-hyperalgesic effects
    • $70
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  • R 396
    T24697129809-09-2
    R 396 (Acleu-asp-gln-trp-phe-glynh2) is a linear hexapeptide and is also an NK-2 tachykinin receptor antagonist.
    • $411
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  • Neurokinin A(4-10)
    T755997559-35-8
    Neurokinin A(4-10)(TFA) is an agonist of tachykinin NK2 receptor .
    • $126
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  • Fosnetupitant chloride monohydrochloride
    T781041643757-72-5
    Fosnetupitant chloride monohydrochloride (Pro-netupitant chloride monohydrochloride) is a selective NK1 antagonist exhibiting high affinity for the human NK1 receptor with a pK i value of 9.5, and a lower affinity for the NK3 receptor with a pK i of 6.1. It serves as a methylene phosphate prodrug of Netupitant [1].
    • Inquiry Price
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  • CS-003 Free base
    T10892191672-52-3
    CS-003 free base (CS-003) is a triple tachykinin receptor antagonist with high affinity for human (neurokinin) NK1, NK2 and NK3 receptors, with Ki values of 2.3 nM and 0.54 nM, respectively And 0.74 nM. CS-003 free base (CS-003) has therapeutic effects on
    • $2,570
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  • Elinzanetant
    T38144929046-33-3
    Elinzanetant is a dual antagonist of neurokinin (NK) receptors 1 and 3 and modulates reproductive hormone secretion.
    • $97
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  • Fosaprepitant dimeglumine
    T1790265121-04-8
    Fosaprepitant dimeglumine (MK-0517) is the dimeglumine salt form of fosaprepitant, the water-soluble, N-phosphorylated prodrug of aprepitant, with antiemetic activity. Upon intravenous administration and rapid conversion to aprepitant, this agent binds selectively to the human substance P neurokinin 1 (NK1) receptors in the central nervous system (CNS). This inhibits receptor binding of the endogenous substance P and prevents substance P-induced emesis.
    • $45
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  • Eprazinone dihydrochloride
    T303410402-53-6
    Eprazinone dihydrochloride (NSC 317935) is a mucolytic with antitussive and mucolytic effect.
    • $33
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  • [D-Pro2] Spantide I TFA
    T80031
    [D-Pro2] Spantide I TFA is an analog of Spantide I, a selective antagonist of the NK1 receptor [1].
    • Inquiry Price
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  • Orvepitant maleate
    T16406579475-24-4
    Orvepitant maleate is an effective, selective, and well-tolerated neurokinin-1 receptor (NK-1) antagonist (pKi: 10.2 for human neurokinin-1 receptor). Orvepitant maleate has the potential for depressive disorder and chronic refractory cough (CRC) treatmen
    • $688
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  • Substance P
    TP108733507-63-0
    Substance P (Neurokinin P) (SP) is an undecapeptide (a peptide composed of a chain of 11 amino acid residues) member of the tachykinin neuropeptide family.
    • $52
    In Stock
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  • Physalaemin
    T195182507-24-6
    Physalaemin is a non-mammalian tachykinin.
    • $1,520
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  • Casopitant mesylate
    T10688414910-30-8
    Casopitant mesylate (GW679769B) is a selective, brain permeable, and orally active antagonist of neurokinin 1 (NK1) receptor. It is a second in the class of antiemetics.
    • $1,330
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  • [Sar9,Met(O2)11]-Substance P
    T7828110880-55-2
    [Sar9,Met(O2)11]-Substance P (NA) is an agonist of NK1 receptor.
    • $77
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  • Neurokinin A
    TP100886933-74-6
    Neurokinin A (NKA), formerly known as Substance K, is a neurologically active peptide translated from the pre-protachykinin gene.
    • $97
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  • NK3R-IN-1
    T787572854331-14-7
    NK3R-IN-1 (compound 16x), an orally active imidazolepiperazine derivative, acts as a Neurokinin Receptor NK3R inhibitor and has been shown to reduce blood luteinizing hormone concentrations in an ovariectomy (OVX) model [1].
    • $1,370
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  • Tradipitant
    T17156622370-35-8
    Tradipitant (VLY-686) is an antagonist of neurokinin-1.
    • $55
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  • Ezlopitant
    T68068147116-64-1
    Ezlopitant (CJ-11974) is a small molecule neurokinin-1-receptor (NK1) antagonist used to treat nausea, vomiting and pain.
    • $85
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  • Maropitant
    T7209147116-67-4
    Maropitant is a selective neurokinin (NK1) receptor antagonist.
    • $31
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