Shopping Cart
  • Remove All
  • TargetMol
    Your shopping cart is currently empty
Filter
TargetMol | Tags GPCR/G Protein
TargetMol | Tags Neuroscience

Neurokinin receptor

The tachykinin receptor 1 (TACR1) also known as neurokinin 1 receptor (NK1R) or substance P receptor (SPR) is a G protein coupled receptor found in the central nervous system and peripheral nervous system. The endogenous ligand for this receptor is Substance P, although it has some affinity for other tachykinins.

Substance P
TP108733507-63-0
Substance P (Neurokinin P) (SP) is an undecapeptide (a peptide composed of a chain of 11 amino acid residues) member of the tachykinin neuropeptide family.
  • $52
In Stock
Size
QTY
Fezolinetant
T152781629229-37-3
Fezolinetant (ESN-364) is a neurokinin-3 receptor antagonist that is being investigated for menopausal hot flashes.
  • $73
In Stock
Size
QTY
Neurokinin B acetate(86933-75-7 free base)
TP1363L
Neurokinin B acetate(86933-75-7 free base) is the acetate form of Neurokinin B, which belongs to the tachykinin family. Neurokinin binds to neurokinin receptor 1 (NK1R), nk2r and NK3R, and mediates its biological effects.
  • $80
In Stock
Size
QTY
Neurokinin A
TP100886933-74-6
Neurokinin A (NKA), formerly known as Substance K, is a neurologically active peptide translated from the pre-protachykinin gene.
  • $56
In Stock
Size
QTY
TargetMol | Inhibitor Sale
SB 218795
T23316174635-53-1
SB 218795 is an effective and selective antagonist of NK3 with a Ki 13 nM for hNK3 which is about 90-fold and 7000-fold selectivity over hNK2 and hNK1.
  • $44
In Stock
Size
QTY
Befetupitant
T14524290296-68-3In house
Befetupitant (Ro67-5930) is a potent and selective tachykinin 1 receptor (NK1R) antagonist for the study of corneal neovascularization.
  • $490
In Stock
Size
QTY
Substance P (7-11)
T755451165-05-0
Substance P (7-11) (Substance P 7-11(TFA)) is a C-terminal fragment of Substance P .
  • $39
In Stock
Size
QTY
TargetMol | Inhibitor Sale
Aprepitant
T1743170729-80-3
Aprepitant is a Substance P Neurokinin-1 Receptor Antagonist. The mechanism of action of aprepitant is as a Neurokinin 1 Antagonist, and Cytochrome P450 3A4 Inhibitor, and Cytochrome P450 2C9 Inducer, and Cytochrome P450 3A4 Inducer.
  • $48
In Stock
Size
QTY
Elinzanetant
T38144929046-33-3
Elinzanetant is a dual antagonist of neurokinin (NK) receptors 1 and 3 and modulates reproductive hormone secretion.
  • $97
In Stock
Size
QTY
Lanepitant 2HCl
T25616170508-05-1In house
Lanepitant 2HCl is a non-peptide neurokinin-1 receptor antagonist with analgesic and anti-inflammatory activity.Lanepitant 2HCl inhibits the binding of Substance P to the neurokinin-1 receptor, inhibits neurogenic inflammation and pain transmission, and can be used in the study of painful neuropathic disorders, such as migraines.
  • $195 TargetMol
In Stock
Size
QTY
Netupitant
T6905290297-26-6
Netupitant (CID 6451149) is a specific neurokinin 1 (NK1) receptor antagonist (Ki: 0.95 nM).
  • $47
In Stock
Size
QTY
Vofopitant
T13329168266-90-8In house
Vofopitant (GR 205171) is a potent NK1 receptor antagonist with anxiolytic and antiemetic activity for the study of post-traumatic stress disorder (PTSD).
  • $100
In Stock
Size
QTY
Rolapitant
T3716552292-08-7
Rolapitant (SCH619734) Hydrochloride is the hydrochloride salt form of rolapitant, an orally bioavailable, centrally-acting, selective, neurokinin 1 receptor (NK1-receptor) antagonist with potential antiemetic activity. Upon oral administration, rolapitant competitively binds to and blocks the activity of the NK1-receptor in the central nervous system, thereby inhibiting the binding of the endogenous ligand, substance P (SP). This may prevent both SP-induced emesis and chemotherapy-induced nausea and vomiting (CINV). The interaction of SP with the NK1-receptor plays a key role in the induction of nausea and vomiting caused by emetogenic cancer chemotherapy. Compared to other NK1-receptor antagonists, rolapitant has both a more rapid onset of action and a much longer half-life.
  • $43
In Stock
Size
QTY
Maropitant
T7209147116-67-4
Maropitant is a selective neurokinin (NK1) receptor antagonist.
  • $43
In Stock
Size
QTY
TargetMol | Inhibitor Sale
Talnetant
T7549174636-32-9
Talnetant (SB 223412) is a selective, competitive NK3 receptor antagonist that penetrates the brain and modulates mesolimbic and mesocortical dopaminergic neurotransmission.
  • $36
In Stock
Size
QTY
TargetMol | Inhibitor Sale
WIN 51,708
T29157144177-30-0In house
WIN 51,708 is a neurokinin receptor (NK1) antagonist.
  • $293
In Stock
Size
QTY
Tradipitant
T17156622370-35-8
Tradipitant (VLY-686) is an antagonist of neurokinin-1.
  • $55
In Stock
Size
QTY
TargetMol | Inhibitor Sale
Pavinetant
T16114941690-55-7In house
Pavinetant (MLE-4901) is an orally available neurokinin-3 receptor (NK3R) antagonist used to improve menopausal symptoms.
  • $74 TargetMol
In Stock
Size
QTY
[Lys5,MeLeu9,Nle10]-NKA(4-10)
TP1883137565-28-7
Highy selective and potent NK2 receptor agonist (IC50 = 6.1 nM). Induces contraction of the rat fundus and bladder (EC50 values are 117 and 10 nM respectively).
  • $103
In Stock
Size
QTY
TargetMol | Inhibitor Sale
Maropitant citrate
T35344359875-09-5
Maropitant citrate is a synthetic neurokinin-1 receptor antagonist and substance P inhibitor, used for controlling vomiting in cats and dogs.
  • $53
In Stock
Size
QTY
Saredutant
T16842142001-63-6
Saredutant (SR 48968) is a selective neurokinin-2 (NK2) receptor antagonist that inhibits the action of neurokinin A by blocking the NK2 receptor, thereby exerting antidepressant and anxiolytic effects.
  • $117
In Stock
Size
QTY
QWF acetate
TP1946L
QWF acetate is a Substance P antagonist that specifically inhibits the binding of Substance P to its receptor (NK1) with an IC50 of 0.09 Μm; it can also inhibit the activation of Mas-related G-protein-coupled receptor X2 (MRGPRX2), which inhibits degranulation of mast cells.QWF acetate is used as a polypeptide in pain, inflammation and allergic reactions, QWF acetate has important applications as a peptide in the study of pain, inflammation and allergic reactions.
  • $236
In Stock
Size
QTY
Hemokinin 1 (human) acetate(491851-53-7 free base)
TP1899L1
Hemokinin 1 (human) acetate is an endogenous substance P homolog that is a selective agonist at the tachykinin NK1 receptor (IC50 values are 1.8, 370 and 480 nM for NK1, NK3 and NK2 receptors respectively). Has proliferative and antiapoptotic actions on B
  • $101
In Stock
Size
QTY
Vofopitant dihydrochloride
T13329L168266-51-1In house
Vofopitant dihydrochloride (GR 205171A) is an orally available, selective tachykinin NK1 receptor antagonist that inhibits [3H]SP binding to NK1 with pKi values of 9.5 and 10.6, respectively. It is a potential compound for the treatment of pathological vomiting.
  • $100
In Stock
Size
QTY