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PPP1R14A Protein, Human, Recombinant (His)

Catalog No. TMPJ-01261
Synonyms: 17 kDa PKC-Potentiated Inhibitory Protein of PP1, CPI17, PPP1R14A, Protein Phosphatase 1 Regulatory Subunit 14A, PPP1INL, CPI-17, Protein Kinase C-Potentiated Inhibitor Protein of 17 kDa

Protein Phosphatase 1 Regulatory Subunit 14A (PPP1R14A) belongs to the PP1 inhibitor family. PPP1R14A is mapped to chromosome 19q13.13-q13.2. PPP1R14A binds directly to protein kinase C and casein kinase I. Meantime, PPP1R14A is a phosphorylation-dependent inhibitor of smooth muscle myosin phosphatase. PPP1R14A is the inhibitor of PPP1CA. When phosphorylated, PPP1R14A has over 1000-fold higher inhibitory activity, creating a molecular switch for regulating the phosphorylation status of PPP1CA substrates and smooth muscle contraction. In addition, inhibition of PPP1R14A also enhances contraction of smooth muscle in the absence of increment of intracellular Ca2+ concentration.

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.
PPP1R14A Protein, Human, Recombinant (His)
Pack Size Availability Price/USD Quantity
10 μg 5 days $ 129.00
50 μg 5 days $ 390.00
500 μg 5 days $ 1,900.00
1 mg 5 days $ 2,730.00
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Biological Description
Technical Params
Product Properties
Description Protein Phosphatase 1 Regulatory Subunit 14A (PPP1R14A) belongs to the PP1 inhibitor family. PPP1R14A is mapped to chromosome 19q13.13-q13.2. PPP1R14A binds directly to protein kinase C and casein kinase I. Meantime, PPP1R14A is a phosphorylation-dependent inhibitor of smooth muscle myosin phosphatase. PPP1R14A is the inhibitor of PPP1CA. When phosphorylated, PPP1R14A has over 1000-fold higher inhibitory activity, creating a molecular switch for regulating the phosphorylation status of PPP1CA substrates and smooth muscle contraction. In addition, inhibition of PPP1R14A also enhances contraction of smooth muscle in the absence of increment of intracellular Ca2+ concentration.
Species Human
Expression System E. coli
Tag C-6His
Accession Number Q96A00
Synonyms 17 kDa PKC-Potentiated Inhibitory Protein of PP1, CPI17, PPP1R14A, Protein Phosphatase 1 Regulatory Subunit 14A, PPP1INL, CPI-17, Protein Kinase C-Potentiated Inhibitor Protein of 17 kDa
Amino Acid Met1-Pro147
Construction Recombinant Human Protein Phosphatase 1 Regulatory Subunit 14A is produced by our E.coli expression system and the target gene encoding Met1-Pro147 is expressed with a 6His tag at the C-terminus.
Protein Purity Greater than 95% as determined by reducing SDS-PAGE. (QC verified)
Molecular Weight 23-26 KDa, reducing conditions
Endotoxin Less than 0.1 ng/µg (1 EU/µg) as determined by LAL test.
Formulation Supplied as a 0.2 μm filtered solution of 20mM Tris-HCl, 0.2mM EDTA, 1mM DTT, 10% Glycerol, pH 8.0.
Stability & Storage

Store at ≤-70°C, stable for 6 months after receipt. Store at ≤-70°C, stable for 3 months under sterile conditions after opening. Please minimize freeze-thaw cycles.
Shipping

The product is shipped on dry ice/polar packs. Upon receipt, store it immediately at the temperature listed below.
Research Background Protein Phosphatase 1 Regulatory Subunit 14A (PPP1R14A) belongs to the PP1 inhibitor family. PPP1R14A is mapped to chromosome 19q13.13-q13.2. PPP1R14A binds directly to protein kinase C and casein kinase I. Meantime, PPP1R14A is a phosphorylation-dependent inhibitor of smooth muscle myosin phosphatase. PPP1R14A is the inhibitor of PPP1CA. When phosphorylated, PPP1R14A has over 1000-fold higher inhibitory activity, creating a molecular switch for regulating the phosphorylation status of PPP1CA substrates and smooth muscle contraction. In addition, inhibition of PPP1R14A also enhances contraction of smooth muscle in the absence of increment of intracellular Ca2+ concentration.

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Keywords

PPP1R14A Protein, Human, Recombinant (His) CPI 17 17 kDa PKC-Potentiated Inhibitory Protein of PP1 CPI17 PPP1R14A Protein Phosphatase 1 Regulatory Subunit 14A PPP1INL CPI-17 Protein Kinase C-Potentiated Inhibitor Protein of 17 kDa recombinant recombinant-proteins proteins protein

 

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