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PPP1R14A Protein, Human, Recombinant (His)
(Synonyms: Protein Phosphatase 1 Regulatory Subunit 14A, Protein Kinase C-Potentiated Inhibitor Protein of 17 kDa, PPP1R14A, PPP1INL, CPI-17, CPI17, 17 kDa PKC-Potentiated Inhibitory Protein of PP1) Copy Product InfoSynonyms: Protein Phosphatase 1 Regulatory Subunit 14A, Protein Kinase C-Potentiated Inhibitor Protein of 17 kDa, PPP1R14A, PPP1INL, CPI-17, CPI17, 17 kDa PKC-Potentiated Inhibitory Protein of PP1
Catalog No. TMPJ-01261 Copy Product Info
Protein Phosphatase 1 Regulatory Subunit 14A (PPP1R14A) belongs to the PP1 inhibitor family. PPP1R14A is mapped to chromosome 19q13.13-q13.2. PPP1R14A binds directly to protein kinase C and casein kinase I. Meantime, PPP1R14A is a phosphorylation-dependent inhibitor of smooth muscle myosin phosphatase. PPP1R14A is the inhibitor of PPP1CA. When phosphorylated, PPP1R14A has over 1000-fold higher inhibitory activity, creating a molecular switch for regulating the phosphorylation status of PPP1CA substrates and smooth muscle contraction. In addition, inhibition of PPP1R14A also enhances contraction of smooth muscle in the absence of increment of intracellular Ca2+ concentration.
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| Pack Size | Price | USA Stock | Global Stock | Quantity |
|---|---|---|---|---|
| 5 μg | $80 | 35 days | 35 days | |
| 10 μg | $129 | 35 days | 35 days | |
| 20 μg | $198 | 35 days | 35 days | |
| 50 μg | $390 | 35 days | 35 days | |
| 100 μg | $626 | 35 days | 35 days | |
| 200 μg | $987 | 35 days | 35 days | |
| 500 μg | $1,900 | 35 days | 35 days | |
| 1 mg | $2,730 | 35 days | 35 days |
For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)
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For research use only—not for human use. No sales to individuals. Use as intended only.
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Product Introduction
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | Protein Phosphatase 1 Regulatory Subunit 14A (PPP1R14A) belongs to the PP1 inhibitor family. PPP1R14A is mapped to chromosome 19q13.13-q13.2. PPP1R14A binds directly to protein kinase C and casein kinase I. Meantime, PPP1R14A is a phosphorylation-dependent inhibitor of smooth muscle myosin phosphatase. PPP1R14A is the inhibitor of PPP1CA. When phosphorylated, PPP1R14A has over 1000-fold higher inhibitory activity, creating a molecular switch for regulating the phosphorylation status of PPP1CA substrates and smooth muscle contraction. In addition, inhibition of PPP1R14A also enhances contraction of smooth muscle in the absence of increment of intracellular Ca2+ concentration. |
| Species | Human |
| Expression System | E. coli |
| Tag | C-6xHis |
| Accession Number | Q96A00 |
| Amino Acid | Met1-Pro147 |
| Construction | Met1-Pro147 |
| Protein Purity | Greater than 95% as determined by reducing SDS-PAGE. (QC verified) |
| Endotoxin | < 0.1 ng/µg (1 EU/µg) as determined by LAL test. |
| Formulation | Supplied as a 0.2 μm filtered solution of 20 mM Tris-HCl, 0.2 mM EDTA, 1 mM DTT, 10% Glycerol, pH 8.0. |
| Stability & Storage | Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at -80°C. For reconstituted protein solutions, the solution can be stored at -20°C to -80°C for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots. |
| Shipping | Proteins are shipped with blue ice. |
| Synonyms | Protein Phosphatase 1 Regulatory Subunit 14A, Protein Kinase C-Potentiated Inhibitor Protein of 17 kDa, PPP1R14A, PPP1INL, CPI-17, CPI17, 17 kDa PKC-Potentiated Inhibitory Protein of PP1 |
| Research Background |
| Molecular Weight | 23-26 KDa (reducing condition) |
| Storage | Store at low temperature Lyophilized powder: -20~-80°C for 1 year | Solution: -80°C for 6 months |
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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Related Tags: PPP1R14A Protein, Human, Recombinant (His) chemical structure | PPP1R14A Protein, Human, Recombinant (His) molecular weight
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