PPP1R14A Protein, Human, Recombinant (His)

Name: PPP1R14A Protein, Human, Recombinant (His)
Brand: TargetMol
SKU: TMPJ-01261
Rating: 4.5 (1 reviews)

(Synonyms: Protein Phosphatase 1 Regulatory Subunit 14A, Protein Kinase C-Potentiated Inhibitor Protein of 17 kDa, PPP1R14A, PPP1INL, CPI-17, CPI17, 17 kDa PKC-Potentiated Inhibitory Protein of PP1) Copy Product Info

Synonyms: Protein Phosphatase 1 Regulatory Subunit 14A, Protein Kinase C-Potentiated Inhibitor Protein of 17 kDa, PPP1R14A, PPP1INL, CPI-17, CPI17, 17 kDa PKC-Potentiated Inhibitory Protein of PP1

Catalog No. TMPJ-01261 Copy Product Info

Protein Phosphatase 1 Regulatory Subunit 14A (PPP1R14A) belongs to the PP1 inhibitor family. PPP1R14A is mapped to chromosome 19q13.13-q13.2. PPP1R14A binds directly to protein kinase C and casein kinase I. Meantime, PPP1R14A is a phosphorylation-dependent inhibitor of smooth muscle myosin phosphatase. PPP1R14A is the inhibitor of PPP1CA. When phosphorylated, PPP1R14A has over 1000-fold higher inhibitory activity, creating a molecular switch for regulating the phosphorylation status of PPP1CA substrates and smooth muscle contraction. In addition, inhibition of PPP1R14A also enhances contraction of smooth muscle in the absence of increment of intracellular Ca2+ concentration.

PPP1R14A Protein, Human, Recombinant (His)

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Pack Size	Price	USA Stock	Global Stock
10 µg	$129	35 days	35 days
20 µg	$198	35 days	35 days
50 µg	$390	35 days	35 days
100 µg	$626	35 days	35 days
200 µg	$987	35 days	35 days
500 µg	$1,900	35 days	35 days
1 mg	$2,730	35 days	35 days

For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)

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For research use only—not for human use. No sales to individuals. Use as intended only.

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User Guide of Recombinant Proteins

Product Introduction

Bioactivity

Bioactivity	Activity has not been tested. It is theoretically active, but we cannot guarantee it. If you require protein activity, we recommend choosing the eukaryotic expression version first.
Description	Protein Phosphatase 1 Regulatory Subunit 14A (PPP1R14A) belongs to the PP1 inhibitor family. PPP1R14A is mapped to chromosome 19q13.13-q13.2. PPP1R14A binds directly to protein kinase C and casein kinase I. Meantime, PPP1R14A is a phosphorylation-dependent inhibitor of smooth muscle myosin phosphatase. PPP1R14A is the inhibitor of PPP1CA. When phosphorylated, PPP1R14A has over 1000-fold higher inhibitory activity, creating a molecular switch for regulating the phosphorylation status of PPP1CA substrates and smooth muscle contraction. In addition, inhibition of PPP1R14A also enhances contraction of smooth muscle in the absence of increment of intracellular Ca2+ concentration.
Species	Human
Expression System	E. coli
Tag	C-6xHis
Accession Number	Q96A00
Amino Acid	Met1-Pro147
Construction	Met1-Pro147
Protein Purity	Greater than 95% as determined by reducing SDS-PAGE. (QC verified)
Endotoxin	< 0.1 ng/µg (1 EU/µg) as determined by LAL test.
Formulation	Supplied as a 0.2 μm filtered solution of 20 mM Tris-HCl, 0.2 mM EDTA, 1 mM DTT, 10% Glycerol, pH 8.0.
Synonyms	Protein Phosphatase 1 Regulatory Subunit 14A, Protein Kinase C-Potentiated Inhibitor Protein of 17 kDa, PPP1R14A, PPP1INL, CPI-17, CPI17, 17 kDa PKC-Potentiated Inhibitory Protein of PP1
Research Background	Protein Phosphatase 1 Regulatory Subunit 14A (PPP1R14A) belongs to the PP1 inhibitor family. PPP1R14A is mapped to chromosome 19q13.13-q13.2. PPP1R14A binds directly to protein kinase C and casein kinase I. Meantime, PPP1R14A is a phosphorylation-dependent inhibitor of smooth muscle myosin phosphatase. PPP1R14A is the inhibitor of PPP1CA. When phosphorylated, PPP1R14A has over 1000-fold higher inhibitory activity, creating a molecular switch for regulating the phosphorylation status of PPP1CA substrates and smooth muscle contraction. In addition, inhibition of PPP1R14A also enhances contraction of smooth muscle in the absence of increment of intracellular Ca2+ concentration.

Chemical Properties

Molecular Weight

23-26 KDa (reducing condition)

Storage & Solubility Information

Shipping	Proteins are shipped with blue ice.
Storage	Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at -80°C. For reconstituted protein solutions, the solution can be stored at -20°C to -80°C for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.