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BTD

Name: BTD
Brand: TargetMol
SKU: T37763
Rating: 4.5 (1 reviews)

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Catalog No. T37763Cas No. 896684-04-1

BTD is a selective transient receptor potential classical 5 (TRPC5) activator, which activates heteromeric channel complexes formed by TRPC5 and its recent relatives TRPC1 or TRPC4, used for studying neurodegenerative diseases.

BTD

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Catalog No. T37763Cas No. 896684-04-1

Pack Size	Price	USA Warehouse	Global Warehouse	Quantity
2 mg	$48	5 days	5 days

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Appearance:Solid

Color:White

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Product Introduction

Bioactivity

Description	BTD is a selective transient receptor potential classical 5 (TRPC5) activator, which activates heteromeric channel complexes formed by TRPC5 and its recent relatives TRPC1 or TRPC4, used for studying neurodegenerative diseases.
Targets&IC50	TRPC5:1.4 μM (EC50)
In vitro	BTD can activate TRPC5 with EC50 values of 1.4 μM (fluorescence microporous Ca2+ analysis) and 1.3 μM (in whole-cell patch-clamp experiments). BTD can activate TRPM8-expressing HEK293 cells with an EC50 value of 20.6 μM. BTD can activate the heteropolymeric channel complex composed of TRPC5 and its close relatives, TRPC1 or TRPC4. [1] BTD treatment down-regulates TRPC5 expression by increasing the activity of protein kinase C, thereby down-regulating downstream pain markers (CAMKII, ERK) in the spinal cord. [2]
In vivo	BTD (1 and 3 mg/kg intraperitoneally injected for 14 days) improved mechanical pain in diabetic neuropathic rats, but did not improve hypothermia or neurological deficits. [2]

Chemical Properties

Molecular Weight	459.6
Formula	C₂₄H₃₃N₃O₄S
Cas No.	896684-04-1
Smiles	O=C(NCCCOC12CC3CC(CC(C3)C1)C2)CCC4=NS(=O)(=O)C5=CC=C(C=C5N4)C

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 80 mg/mL (174.06 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.1758 mL	10.8790 mL	21.7581 mL	108.7903 mL
5 mM	0.4352 mL	2.1758 mL	4.3516 mL	21.7581 mL
10 mM	0.2176 mL	1.0879 mL	2.1758 mL	10.8790 mL
20 mM	0.1088 mL	0.5440 mL	1.0879 mL	5.4395 mL
50 mM	0.0435 mL	0.2176 mL	0.4352 mL	2.1758 mL
100 mM	0.0218 mL	0.1088 mL	0.2176 mL	1.0879 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

BTD

BTD

BTD

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