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Methisazone (Synonyms: Marboran, Compound 33T57)

Name: Methisazone
Brand: TargetMol
SKU: T24455
Price: 33 USD
Availability: InStock
Rating: 5 (10 reviews)

Catalog No. T24455 Copy Product Info

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Methisazone is an antiviral agent that acts by inhibiting mRNA and protein synthesis. Methisazone also exhibits inhibitory activity against SARS-CoV-2, with vaccinia virus as its main target.

Methisazone

Copy Product Info

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Catalog No. T24455

Synonyms Marboran, Compound 33T57

Methisazone is an antiviral agent that acts by inhibiting mRNA and protein synthesis. Methisazone also exhibits inhibitory activity against SARS-CoV-2, with vaccinia virus as its main target.

Cas No. 1910-68-5

Pack Size	Price	USA Stock	Global Stock	Quantity
2 mg	$33	-	In Stock
5 mg	Preferential	-	In Stock

For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)

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For research use only—not for human use. No sales to individuals. Use as intended only.

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Appearance:Solid

Color:Yellow

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COA

Product Introduction

Bioactivity

Description	Methisazone is an antiviral agent that acts by inhibiting mRNA and protein synthesis. Methisazone also exhibits inhibitory activity against SARS-CoV-2, with vaccinia virus as its main target.
Targets&IC50	Elstree:0.5 μM (EC50), IHD:0.12 μM (EC50), Copenhagen:3.3 μM (EC50), NYC:0.3 μM (EC50), IHD:0.11 μM (EC50), WR:0.06 μM (EC50)
In vitro	The EC₅₀ values of Methisazone against six vaccinia virus strains (Copenhagen, WR, NYC, Elstree, IHD, IHD) were 3.3, 0.06, 0.3, 0.5, 0.12, and 0.11 μM, respectively [3].
In vivo	Methisazone (10, 30 mg/kg, once daily for 5 consecutive days) administered intraperitoneally 24–48 hours after VV-IHD viral challenge in female BALB/c mice significantly reduces mortality. The 10 mg/kg dose also delays or reduces viral replication in target organs including the liver, spleen, and kidneys [3].
Synonyms	Marboran, Compound 33T57

Chemical Properties

Molecular Weight	234.28
Formula	C₁₀H₁₀N₄OS
Cas No.	1910-68-5
Smiles	O=C1C(=NNC(=S)N)C=2C=CC=CC2N1C
Relative Density.	1.3101 g/cm3 (Estimated)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 80 mg/mL (341.47 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	4.2684 mL	21.3420 mL	42.6840 mL	213.4198 mL
5 mM	0.8537 mL	4.2684 mL	8.5368 mL	42.6840 mL
10 mM	0.4268 mL	2.1342 mL	4.2684 mL	21.3420 mL
20 mM	0.2134 mL	1.0671 mL	2.1342 mL	10.6710 mL
50 mM	0.0854 mL	0.4268 mL	0.8537 mL	4.2684 mL
100 mM	0.0427 mL	0.2134 mL	0.4268 mL	2.1342 mL

Note : The dilution table applies only to solid products. For liquid products, please calculate the stock solution based on the stated concentration and/or density.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc