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Upacicalcet

🥰Excellent
Catalog No. T29067Cas No. 1333218-50-0
Alias SK-1403, PLS-240, AJT-240

Upacicalcet (AJT-240) is an intraventricular calcium mimetic, a SHPT available for human hemodialysis, that inhibits excessive parathyroid hormone (PTH) secretion by directly acting on parathyroid cell membrane calcium-sensitive receptors, thereby lowering blood levels of PTH.Upacicalcet is an orthosteric modulator of calcium-sensitive receptors and prevents adenine-induced secondary vascular calcification and bone disease in a rat model of adenine-induced secondary hyperparathyroidism.

Upacicalcet
Other Forms of Upacicalcet:

Upacicalcet

🥰Excellent
Purity: 99.83%
Catalog No. T29067Alias SK-1403, PLS-240, AJT-240Cas No. 1333218-50-0
Upacicalcet (AJT-240) is an intraventricular calcium mimetic, a SHPT available for human hemodialysis, that inhibits excessive parathyroid hormone (PTH) secretion by directly acting on parathyroid cell membrane calcium-sensitive receptors, thereby lowering blood levels of PTH.Upacicalcet is an orthosteric modulator of calcium-sensitive receptors and prevents adenine-induced secondary vascular calcification and bone disease in a rat model of adenine-induced secondary hyperparathyroidism.
Pack SizePriceUSA WarehouseGlobal WarehouseQuantity
1 mg$110In StockIn Stock
5 mg$270In StockIn Stock
10 mg$400In StockIn Stock
25 mg$668In StockIn Stock
50 mg$949In StockIn Stock
100 mg$1,290In StockIn Stock
500 mg$2,580-In Stock
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products. However, due to objective factors, there is a small probability that the synthesis may not be successful during the R&D process. We appreciate your understanding. If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.
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Purity:99.83%
ee:100%
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Product Introduction

Bioactivity
Description
Upacicalcet (AJT-240) is an intraventricular calcium mimetic, a SHPT available for human hemodialysis, that inhibits excessive parathyroid hormone (PTH) secretion by directly acting on parathyroid cell membrane calcium-sensitive receptors, thereby lowering blood levels of PTH.Upacicalcet is an orthosteric modulator of calcium-sensitive receptors and prevents adenine-induced secondary vascular calcification and bone disease in a rat model of adenine-induced secondary hyperparathyroidism.
SynonymsSK-1403, PLS-240, AJT-240
Chemical Properties
Molecular Weight351.76
FormulaC11H14ClN3O6S
Cas No.1333218-50-0
SmilesN(C(NC[C@@H](C(O)=O)N)=O)C1=CC(S(=O)(=O)O)=CC(Cl)=C1C
Relative Density.1.643 g/cm3 (Predicted)
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
DMSO: 50 mg/mL (142.14 mM), Sonication is recommended.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM2.8428 mL14.2142 mL28.4285 mL142.1424 mL
5 mM0.5686 mL2.8428 mL5.6857 mL28.4285 mL
10 mM0.2843 mL1.4214 mL2.8428 mL14.2142 mL
20 mM0.1421 mL0.7107 mL1.4214 mL7.1071 mL
50 mM0.0569 mL0.2843 mL0.5686 mL2.8428 mL
100 mM0.0284 mL0.1421 mL0.2843 mL1.4214 mL

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TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.
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Keywords

UpacicalcetSK1403SK 1403PLS240PLS 240CalciumChannelCalcium ChannelAJT240AJT 240
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