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CACNA1C Protein, Guinea Pig, Recombinant (His)
(Synonyms: Voltage-gated calcium channel subunit alpha Cav1.2, Voltage-dependent L-type calcium channel subunit alpha-1C, CCHL1A1, Calcium channel, L type, alpha-1 polypeptide, isoform 1, cardiac muscle, CACNL1A1, CACNA1C, CACN2, CACH2) Copy Product InfoSynonyms: Voltage-gated calcium channel subunit alpha Cav1.2, Voltage-dependent L-type calcium channel subunit alpha-1C, CCHL1A1, Calcium channel, L type, alpha-1 polypeptide, isoform 1, cardiac muscle, CACNL1A1, CACNA1C, CACN2, CACH2
Catalog No. TMPH-00780 Copy Product Info
Pore-forming, alpha-1C subunit of the voltage-gated calcium channel that gives rise to L-type calcium currents. Mediates influx of calcium ions into the cytoplasm, and thereby triggers calcium release from the sarcoplasm. Plays an important role in excitation-contraction coupling in the heart. Required for normal heart development and normal regulation of heart rhythm. Required for normal contraction of smooth muscle cells in blood vessels and in the intestine. Essential for normal blood pressure regulation via its role in the contraction of arterial smooth muscle cells. Long-lasting (L-type) calcium channels belong to the 'high-voltage activated' (HVA) group.
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| Pack Size | Price | USA Stock | Global Stock | Quantity |
|---|---|---|---|---|
| 5 μg | $289 | 20 days | 20 days | |
| 10 μg | $485 | 20 days | 20 days | |
| 20 μg | $817 | 20 days | 20 days | |
| 50 μg | $1,130 | 20 days | 20 days | |
| 100 μg | $1,450 | 20 days | 20 days |
For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)
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For research use only—not for human use. No sales to individuals. Use as intended only.
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Product Introduction
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | Pore-forming, alpha-1C subunit of the voltage-gated calcium channel that gives rise to L-type calcium currents. Mediates influx of calcium ions into the cytoplasm, and thereby triggers calcium release from the sarcoplasm. Plays an important role in excitation-contraction coupling in the heart. Required for normal heart development and normal regulation of heart rhythm. Required for normal contraction of smooth muscle cells in blood vessels and in the intestine. Essential for normal blood pressure regulation via its role in the contraction of arterial smooth muscle cells. Long-lasting (L-type) calcium channels belong to the 'high-voltage activated' (HVA) group. |
| Species | Guinea pig |
| Expression System | E. coli |
| Tag | N-10xHis |
| Accession Number | O35505 |
| Amino Acid | FQEQGEQEYKNCELDKNQRQCVEYALKARPLRRYIPISITFFRLFRVMRLVKLLSRGEGIRTLLWTFIKSFQALPYVALLIVMLFFIYAVIGMQVFGKIALNDTTEINRNNNFQTFPQAVLLLFRCATGEAWQDIMLACMPGKKRAPESEPSNSTEGETPCGSSFAVFY |
| Construction | 1-169 aa |
| Protein Purity | > 85% as determined by SDS-PAGE. |
| Endotoxin | < 1.0 EU/μg of the protein as determined by the LAL method. |
| Formulation | If the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol.If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, pH 8.0. |
| Reconstitution | Reconstitute the lyophilized protein in sterile deionized water. The product concentration should not be less than 100 μg/mL. Before opening, centrifuge the tube to collect powder at the bottom. After adding the reconstitution buffer, avoid vortexing or pipetting for mixing. |
| Stability & Storage | Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at -80°C. For reconstituted protein solutions, the solution can be stored at -20°C to -80°C for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots. |
| Shipping | In general, lyophilized powders are shipped with blue ice, while solutions are shipped with dry ice. |
| Synonyms | Voltage-gated calcium channel subunit alpha Cav1.2, Voltage-dependent L-type calcium channel subunit alpha-1C, CCHL1A1, Calcium channel, L type, alpha-1 polypeptide, isoform 1, cardiac muscle, CACNL1A1, CACNA1C, CACN2, CACH2 |
| Research Background |
| Molecular Weight | 22.3 kDa (predicted) |
| Storage | Lyophilized powder: -20~-80°C for 1 year | Solution: -80°C for 6 months |
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
Keywords
Voltage-gated calcium channel subunit α Cav1.2Voltage-gated calcium channel subunit a Cav1.2Voltage-dependent L-type calcium channel subunit α-1CVoltage-dependent L-type calcium channel subunit a-1CCCHL1A 1Calcium channel, L type, α-1 polypeptide, isoform 1, cardiac muscleCalcium channel, L type, a-1 polypeptide, isoform 1, cardiac muscleCACNL1A 1CACN 2CACH 2
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Related Tags: CACNA1C Protein, Guinea Pig, Recombinant (His) chemical structure | CACNA1C Protein, Guinea Pig, Recombinant (His) molecular weight
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