Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Potent EGFR Degrader (DC50 values are 39.2 nM for wild-type EGFR in OVCAR8 cells and 736 nM for Exon20Ins mutated EGFR in HeLa cells). Also degrades HER2. Comprises the EGFR inhibitor lapatinib joined by a linker to a von Hippel-Lindau (VHL) recruiting ligand. Inhibits proliferation of HER2-driven breast cancer cell lines (IC50 = 102 nM for SKBr3 cells).
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
5 mg | 35 days | $ 987.00 |
Description | Potent EGFR Degrader (DC50 values are 39.2 nM for wild-type EGFR in OVCAR8 cells and 736 nM for Exon20Ins mutated EGFR in HeLa cells). Also degrades HER2. Comprises the EGFR inhibitor lapatinib joined by a linker to a von Hippel-Lindau (VHL) recruiting ligand. Inhibits proliferation of HER2-driven breast cancer cell lines (IC50 = 102 nM for SKBr3 cells). |
Molecular Weight | 1030.61 |
Formula | C55H57ClFN7O8S |
CAS No. | 2230821-38-0 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 103.06 mg/mL(100 mM)
You can also refer to dose conversion for different animals. More
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SJF 1528 2230821-38-0 SJF1528 SJF-1528 inhibitor inhibit