Shopping Cart
  • Remove All
  • TargetMol
    Your shopping cart is currently empty
TargetMol | Tags Metabolism
ANGPTL
(4)
ATP Citrate Lyase
(15)
Acetyl-CoA Carboxylase
(32)
Aconitase
(2)
Acyltransferase
(145)
Adenosine Deaminase
(16)
AhR
(31)
Amino Acids and Derivatives
(1026)
Aminopeptidase
(70)
Amylase
(41)
Angiotensin-converting Enzyme (ACE)
(172)
Apolipoprotein
(9)
CETP
(17)
CPT
(5)
Calcium Channel
(628)
Carbonic Anhydrase
(215)
Casein Kinase
(159)
Cytochromes P450
(491)
DHFR
(58)
Decarboxylase
(7)
Dehydrogenase
(468)
Drug Metabolite
(587)
Endogenous Metabolite
(3224)
Epoxide Hydrolase
(57)
FAAH
(72)
FABP
(15)
FXR
(78)
Factor VIII
(6)
Factor VIIa
(5)
Factor Xa
(92)
Fatty Acid Synthase
(70)
GSNOR
(3)
Glucokinase
(71)
Glucosidase
(219)
Glutathione Peroxidase
(73)
Glyoxalase
(17)
HIF/HIF Prolyl-Hydroxylase
(194)
HMG-CoA Reductase
(69)
HSP
(264)
Hexokinase
(9)
Hydrogenase
(2)
Hydroxylase
(45)
IDO
(94)
Indoleamine 2,3-Dioxygenase (IDO)
(98)
Isocitrate Dehydrogenase (IDH)
(46)
LDL
(26)
LDLR
(14)
Lipase
(37)
Lipid
(44)
Liposome
(442)
Lipoxygenase
(194)
Liver X Receptor
(51)
MAGL
(61)
MAO
(108)
Mitochondrial Metabolism
(212)
N-Acetylglucosaminyltransferase
(1)
NADPH
(62)
NAMPT
(44)
NEDD4-1
(3)
NEDD8
(8)
NUDIX hydrolase
(2)
Neprilysin
(31)
PAI-1
(38)
PDE
(528)
PGK1
(3)
PKM
(43)
PPAR
(386)
Phosphatase
(432)
Phospholipase
(201)
Phosphorylase
(21)
Photosystem (PS)
(5)
Procollagen C Proteinase
(1)
Prolyl Endopeptidase (PREP)
(33)
RAR/RXR
(12)
REV-ERB
(9)
ROR
(96)
Reactive Oxygen Species
(773)
Reductase
(121)
Retinoid Receptor
(109)
SGK
(24)
Serine/threonin kinase
(90)
Stearoyl-CoA Desaturase (SCD)
(29)
Taste receptor
(6)
Thioredoxin
(2)
Transaminase
(3)
Transferase
(222)
Transketolase
(9)
UGT
(17)
Vitamin
(89)
Xanthine Oxidase
(73)
glycosidase
(28)
hCE
(2)
stilbene oxidase
(1)
transporter
(87)

Cytochromes P450

Cytochromes P450 (CYPs) are a superfamily of enzymes containing heme as a cofactor that function as monooxygenases. In mammals, these proteins oxidize steroids, fatty acids, and xenobiotics, and are important for the clearance of various compounds, as well as for hormone synthesis and breakdown. In plants, these proteins are important for the biosynthesis of defensive compounds, fatty acids, and hormones.CYPs are, in general, the terminal oxidase enzymes in electron transfer chains, broadly categorized as P450-containing systems. The term "P450" is derived from the spectrophotometric peak at the wavelength of the absorption maximum of the enzyme (450 nm) when it is in the reduced state and complexed with carbon monoxide. Most CYPs require a protein partner to deliver one or more electrons to reduce the iron (and eventually molecular oxygen).

Hypericin
T6S0923548-04-9
Hypericin (Cyclosan) is a natural anthraquinone compound, an extract of Hypericum perforatum, which inhibits PKC, MAO, dopamine-beta-hydroxylase, reverse transcriptase, telomerase, and CYP, etc. Hypericin exhibits antimicrobial, antiviral, antitumor, and antidepressant activities.
  • $52
In Stock
Size
QTY
Stiripentol
T449849763-96-4
Stiripentol (BCX2600) (STP) is an anticonvulsant agent, which can inhibit N-demethylation of CLB to NCLB mediated by CYP3A4 (noncompetitively) and CYP2C19 (competitively) with Ki of 1.59/0.516 μM and IC50 of 1.58/3.29 μM, respectively.
  • $47
In Stock
Size
QTY
TargetMol | Citations Cited
Apigenin
T2175520-36-5
Apigenin (NSC 83244) is an aromatic oil extracted from the flowers or leaves of the daisy-like plants. Extracts, oils and teas made from chamomile are used for its soothing qualities as a sedative, mild analgesic and sleep medication. Apigenin has not been implicated in causing serum enzyme elevations or clinically apparent liver injury.
  • $45
In Stock
Size
QTY
TargetMol | Citations Cited
Glycycoumarin
TN170294805-82-0
Glycycoumarin is an estrogen agonist, it shows moderate inhibitory effects against CYP1A2 and CYP2B6.
  • $35
In Stock
Size
QTY
TargetMol | Inhibitor Sale
PC945
T123761931946-73-4In house
PC945 (Opelconazole) is a potent broad-spectrum antifungal compound with inhibitory effect on fumonisinol 14α-demethylase (CYP51A CYP51B), which can be used in the study of fungal infections of the lungs.
  • $139
In Stock
Size
QTY
Furafylline
T741080288-49-9
Furafylline is a selective inhibitor of human cytochrome P450 (CYP)1A2 (IC50 : 0.07 µM),
  • $122
In Stock
Size
QTY
Verapamil
T2065652-53-9
Verapamil (CP-16533-1) is a calcium channel blocker and an orally active and effective inhibitor of P-gp. Verapamil inhibits CYP3A4 and can be used in studies about the treatment of high blood pressure, heart arrhythmias, and angina research.
  • $30
In Stock
Size
QTY
TargetMol | Citations Cited
Tauroursodeoxycholate
T253214605-22-2
Tauroursodeoxycholate (UR 906), also known as ursodoxicoltaurine, is a highly hydrophilic tertiary bile acid that is produced in humans at a low concentration. Tauroursodeoxycholate is the more hydrophilic form of ursodeoxycholic acid, which is the more abundant naturally produced bile acid in humans.Tauroursodeoxycholate is being investigated for use in several conditions such as Primary Biliary Cirrhosis (PBC), insulin resistance, amyloidosis, Cystic Fibrosis, Cholestasis, and Amyotrophic Lateral Sclerosis.
  • $37
In Stock
Size
QTY
TargetMol | Inhibitor Hot
TargetMol | Citations Cited
Letrozole
T1590112809-51-5
Letrozole (CGS 20267) is an Aromatase Inhibitor. The mechanism of action of letrozole is as an Aromatase Inhibitor.
  • $31
In Stock
Size
QTY
TargetMol | Citations Cited
Lasiodin
TN185428957-08-6
Lasiodin (Lasiokaurin) is a diterpene compound from the plant Camellia sinensis that inhibits the proliferation of NPC cells. Lasiodin has antioxidant, antitumor and antibacterial activities, induces cell cycle length and apoptosis, induces cell migration and invasion, and can be used in the study of nasopharyngeal carcinoma.
  • $132
In Stock
Size
QTY
Troleandomycin
T211482751-09-9
Troleandomycin (Triacetyloleandomycin), a macrolide antibiotic, is an orally active and specific CYP3A inhibitor that induces mnemonic speech, induces prolonged cholestasis, and can be used in the study of asthma.
  • $499
In Stock
Size
QTY
Avasimibe
T2753166518-60-1
Avasimibe (PD-148515) is an orally bioavailable inhibitor of acyl-Coenzyme A: cholesterol acyltransferase (ACAT, IC50: 3.3 μM) that prevents cholesterol deposition in the arterial wall. It also inhibits human P450 isoenzymes CYP2C9/1A2/2C19 (IC50: 2.9/13.9/26.5 μM).
  • $43
In Stock
Size
QTY
Naringenin
T2838480-41-1
Naringenin (NSC-11855) is a flavanone that is considered to have a bioactive effect on human health as antioxidant, free radical scavenger, antiinflammatory, carbohydrate metabolism promoter, immunity system modulater. This substance has also been shown to repair DNA.
  • $50
In Stock
Size
QTY
TargetMol | Citations Cited
Cobicistat
T62461004316-88-4
Cobicistat (GS-9350) is a carbamate and thiazole derivative that functions as a CYTOCHROME P450 CYP3A INHIBITOR to enhance the concentration of ANTI-HIV AGENTS, with which it is used in combination, for the treatment of HIV INFECTIONS.
  • $38
In Stock
Size
QTY
TargetMol | Inhibitor Sale
TargetMol | Citations Cited
Salvianolic Acid C
T3149115841-09-3
Salvianolic Acid C is extracted from the root of Salvia miltiorrhiza, a perennial plant in the genus Salvia.
  • $36
In Stock
Size
QTY
TargetMol | Citations Cited
(S)-(+)-N-3-Benzylnirvanol
T67926790676-40-3
(S)-(+)-N-3-Benzylnirvanol is a cytochrome P450 CYP2C19 inhibitor with a ki value of 82.5μM for CYP2C9 and 0.25μM for CYP2C19, which can be used to study HIV infection.
  • $147
In Stock
Size
QTY
Ginsenoside Rd
T287852705-93-8
Ginsenoside Rd (Gypenoside VIII) may have properties that inhibit or prevent the growth of tumors.
  • $33
In Stock
Size
QTY
TargetMol | Citations Cited
Amentoflavone
T34171617-53-4
Amentoflavone (3',8''-Biapigenin), as a potent inhibitor of CYP3A4 and CYP2C9, can interact with many other medications. CYP3A4 and CYP2C9 are proteins used for drug metabolism in the body. Amentoflavone also is an inhibitor of human cathepsin B. It has antimalarial activity in trials significant affinities towards the Delta-1, kappa opioid receptors (as an antagonist) and binds to benzodiazepine receptors. Amentoflavone may be a potential lead for a new type of anti-inflammatory agents having the dual inhibitory activity of group II phospholipase A2 and cyclooxygenase. Amentoflavone and quercetin differentially exerted suppression of PGE2 biosynthesis via downregulation of COX-2/iNOS expression.
  • $32
In Stock
Size
QTY
TargetMol | Inhibitor Sale
TargetMol | Citations Cited
Glabrol
TN169159870-65-4
5-Methylcytosine is a methylated nucleotide base found in eukaryotic DNA. It is an epigenetic modification formed by the action of DNA methyltransferases.
  • $73
In Stock
Size
QTY
Retrorsine
TN2147480-54-6
Retrorsine selectively inhibits hepatocyte proliferation and following liver injury evokes small hepatocyte-like progenitor cells. Retrorsine can be used for the research of hepatocellular injury.
  • $127
7-10 days
Size
QTY
Chrysosplenetin
TJS1159603-56-5
Chrysosplenetin is a metabolic inhibitor of artemisinin.
  • $55
In Stock
Size
QTY
Oxiconazole
T2069364211-45-6
Oxiconazole is a broad-spectrum imidazole antifungal agent with fungicidal activity against T. rubrum, T. mentagrophytes, T. tonsurans, T. violaceum, E. floccosum, M. canis, M. audouini, M. gypseum, C. albicans, and M. furfur. have fungicidal activity, inhibiting ergosterol biosynthesis and disrupting fungal cell membrane integrity by disrupting cytochrome P450 enzymes (lanosterol 14- α demethylase). It also inhibits DNA synthesis and suppresses intracellular ATP concentration.
  • $293
In Stock
Size
QTY
Galangin
T3668548-83-4
Galangin (Norizalpinin) is an agonist/antagonist of the arylhydrocarbon receptor, and also shows inhibition of CYP1A1 activity.
  • $30
In Stock
Size
QTY
TargetMol | Citations Cited
Ginsenoside C-K
T381139262-14-1
Ginsenoside C-K (Ginsenoside K) is a bacterial metabolite of G-Rb1 exhibiting anti-inflammatory effects by reducing iNOS and COX-2.
  • $30
In Stock
Size
QTY
TargetMol | Citations Cited