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GFRAL/GFR alpha-like Protein, Cynomolgus, Recombinant (His & Avi), Biotinylated
(Synonyms: GRAL, GFRAL/GFR α-like Protein, GFRAL, GFR α-like, GFR alpha-like, C6orf144) Copy Product InfoSynonyms: GRAL, GFRAL/GFR α-like Protein, GFRAL, GFR α-like, GFR alpha-like, C6orf144
Catalog No. TMPK-01320 Copy Product Info
GFR alpha -like (GDNF receptor-alpha-like) is a distant member of the GDNFR family of proteins. Mature human GFR alpha-like is a 376 amino acid (aa) type I transmembrane protein. It contains a 333 aa extracellular domain, a 20 aa transmembrane domain and a 23 aa cytoplasmic domain.GFRAL is a brainstem-restricted receptor for GDF15 which regulates food intake, energy expenditure and body weight in response to metabolic and toxin-induced stresses. GFRAL/GFR alpha-like Protein, Cynomolgus, Recombinant (His & Avi), Biotinylated is expressed in HEK293 mammalian cells with N-His-Avi tag. The predicted molecular weight is 40.7 kDa and the accession number is XP_015304775.2.
| Pack Size | Price | USA Stock | Global Stock | Quantity |
|---|---|---|---|---|
| 10 µg | $168 | 7-10 days | 7-10 days | |
| 20 µg | $279 | 7-10 days | 7-10 days | |
| 50 µg | $552 | 7-10 days | 7-10 days | |
| 100 µg | $932 | 7-10 days | 7-10 days | |
| 200 µg | $1,680 | 7-10 days | 7-10 days | |
| 500 µg | $3,720 | 7-10 days | 7-10 days |
For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)
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For research use only—not for human use. No sales to individuals. Use as intended only.
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Product Introduction
Bioactivity
Chemical Properties
Storage & Solubility Information
| Bioactivity | Immobilized Cynomolgus GDF15, His Tag at 2μg/ml (100μl/well) on the plate. Dose response curve for Biotinylated Cynomolgus GFRAL, His Tag with the EC50 of 76.3ng/ml determined by ELISA. |
| Description | GFR alpha -like (GDNF receptor-alpha-like) is a distant member of the GDNFR family of proteins. Mature human GFR alpha-like is a 376 amino acid (aa) type I transmembrane protein. It contains a 333 aa extracellular domain, a 20 aa transmembrane domain and a 23 aa cytoplasmic domain.GFRAL is a brainstem-restricted receptor for GDF15 which regulates food intake, energy expenditure and body weight in response to metabolic and toxin-induced stresses. GFRAL/GFR alpha-like Protein, Cynomolgus, Recombinant (His & Avi), Biotinylated is expressed in HEK293 mammalian cells with N-His-Avi tag. The predicted molecular weight is 40.7 kDa and the accession number is XP_015304775.2. |
| Species | Cynomolgus |
| Expression System | HEK293 Cells |
| Tag | N-His-Avi |
| Accession Number | XP_015304775.2 |
| Construction | Gln20-Glu351 |
| Protein Purity | > 95% as determined by Tris-Bis PAGE; > 95% as determined by HPLC |
| Endotoxin | < 1.0 EU/μg of the protein as determined by the LAL method. |
| Formulation | Supplied as 0.22 μm filtered solution in 20 mM PB, 400 mM NaCl (pH 6.0). |
| Synonyms | GRAL, GFRAL/GFR α-like Protein, GFRAL, GFR α-like, GFR alpha-like, C6orf144 |
| Research Background | GFR alpha -like (GDNF receptor-alpha-like) is a distant member of the GDNFR family of proteins. Mature human GFR alpha-like is a 376 amino acid (aa) type I transmembrane protein. It contains a 333 aa extracellular domain, a 20 aa transmembrane domain and a 23 aa cytoplasmic domain.GFRAL is a brainstem-restricted receptor for GDF15 which regulates food intake, energy expenditure and body weight in response to metabolic and toxin-induced stresses. |
| Molecular Weight | 40.7 kDa (predicted). Due to glycosylation, the protein migrates to 50-70 kDa based on Tris-Bis PAGE result. |
| Shipping | Proteins are shipped with blue ice. |
| Storage | It is recommended to store the product under sterile conditions at -70°C or lower. Samples are stable for up to 12 months at -80°C. Please avoid multiple freeze-thaw cycles and store products in aliquots. |
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Related Tags: GFRAL/GFR alpha-like Protein, Cynomolgus, Recombinant (His & Avi), Biotinylated chemical structure | GFRAL/GFR alpha-like Protein, Cynomolgus, Recombinant (His & Avi), Biotinylated molecular weight
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