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Anti-SOCS1 Antibody (9R848)
😃Good
Catalog No. TMAB-13016
Anti-SOCS1 Antibody (9R848) is a Mouse antibody targeting SOCS1. Anti-SOCS1 Antibody (9R848) can be used in IHC-P,IHC-Fr,IF.
Anti-SOCS1 Antibody (9R848)
Anti-SOCS1 Antibody (9R848)
😃Good
Catalog No. TMAB-13016
Anti-SOCS1 Antibody (9R848) is a Mouse antibody targeting SOCS1. Anti-SOCS1 Antibody (9R848) can be used in IHC-P,IHC-Fr,IF.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 50 μL | $222 | 7-10 days | 7-10 days | |
| 100 μL | $374 | 7-10 days | 7-10 days |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Product Introduction
Bioactivity
Antigen Details
Chemical Properties
| Description | Anti-SOCS1 Antibody (9R848) is a Mouse antibody targeting SOCS1. Anti-SOCS1 Antibody (9R848) can be used in IHC-P,IHC-Fr,IF. |
| Ig Type | IgG1 |
| Clone | 9R848 |
| Reactivity | Human,Rat (predicted:Mouse) |
| Application | |
| Recommended Dose | IHC-P: 1:100-500; IHC-Fr: 1:100-500; IF: 1:100-500 |
| Antibody Type | Monoclonal |
| Host Species | Mouse |
| Subcellular Localization | Nucleus. Cytoplasmic vesicle. Note=Detected in perinuclear cytoplasmic vesicles upon interaction with FGFR3. |
| Tissue Specificity | Expressed in all tissues with high expression in spleen, small intestine and peripheral blood leukocytes. |
| Construction | Hybridoma Monoclonal Antibody |
| Purification | Protein A purified |
| Appearance | Liquid |
| Formulation | PBS, pH7.4, containing 0.02% Proclin300 as Preservative and 50% Glycerol. |
| Concentration | 1mg/ml |
| Research Background | SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. SOCS1 is involved in negative regulation of cytokines that signal through the JAK/STAT3 pathway. Through binding to JAKs, inhibits their kinase activity. In vitro, also suppresses Tec protein-tyrosine activity (By similarity). Appears to be a major regulator of signaling by interleukin 6 (IL6) and leukemia inhibitory factor(LIF). Regulates interferon-gamma mediated sensory neuron survival. Implicated, through SOCS box binding, in ubiquitin-dependent protein degradation. High expression in thymus. Lower expression in lung and spleen. |
| Immunogen | KLH conjugated synthetic peptide: human Socs 1 |
| Antigen Species | Human |
| Gene Name | SOCS1 |
| Gene ID | |
| Protein Name | Suppressor of cytokine signaling 1 |
| Uniprot ID | |
| Function | SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. SOCS1 is involved in negative regulation of cytokines that signal through the JAK/STAT3 pathway. Through binding to JAKs, inhibits their kinase activity. In vitro, also suppresses Tec protein-tyrosine activity. Appears to be a major regulator of signaling by interleukin 6 (IL6) and leukemia inhibitory factor (LIF). Regulates interferon-gamma mediated sensory neuron survival (By similarity). Probable substrate recognition component of an ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Seems to recognize JAK2. SOCS1 appears to be a negative regulator in IGF1R signaling pathway. |
| Molecular Weight | Theoretical: 23 kDa. |
Stability & Storage
| Stability & Storage | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| Transport | Shipping with blue ice. |
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