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VVD-214

Name: VVD-214
Brand: TargetMol
SKU: T85309
Price: 397 USD
Availability: InStock
Rating: 5 (10 reviews)

🥰Excellent

Catalog No. T85309Cas No. 3026500-20-6

Alias VVD214, VVD-133214, VVD133214, RO-7589831, RO7589831

VVD-214 (RO7589831) is a WRN deconjugating enzyme lethal variant inhibitor with potential antitumor activity, inhibits ATP hydrolysis and deconjugating enzyme activity, and can be used in the study of proliferative diseases.

VVD-214

🥰Excellent

Purity: 99.93%

Catalog No. T85309Alias VVD214, VVD-133214, VVD133214, RO-7589831, RO7589831Cas No. 3026500-20-6

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$66	In Stock	In Stock
5 mg	$158	In Stock	In Stock
10 mg	$248	In Stock	In Stock
25 mg	$397	-	In Stock
50 mg	Preferential	-	In Stock
1 mL x 10 mM (in DMSO)	$176	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.93%

Resource Download

COA LCMS HNMR

Product Introduction

Bioactivity

Description	VVD-214 (RO7589831) is a WRN deconjugating enzyme lethal variant inhibitor with potential antitumor activity, inhibits ATP hydrolysis and deconjugating enzyme activity, and can be used in the study of proliferative diseases.
Synonyms	VVD214, VVD-133214, VVD133214, RO-7589831, RO7589831

Chemical Properties

Molecular Weight	437.46
Formula	C₂₀H₂₁F₂N₃O₄S
Cas No.	3026500-20-6
Smiles	O(C=1C(C(N[C@H](/C=C/S(C)(=O)=O)C2CC2)=O)=CN=C(C(C)(F)F)N1)C3=CC=CC=C3
Relative Density.	1.355 g/cm3 at 20℃ (Predicted)
Color	White
Appearance	Solid

Storage & Solubility Information

Storage

store at low temperature,keep away from direct sunlight | store at -20°C | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 80 mg/mL (182.87 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 3.3 mg/mL (7.54 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.2859 mL	11.4296 mL	22.8592 mL	114.2962 mL
5 mM	0.4572 mL	2.2859 mL	4.5718 mL	22.8592 mL
10 mM	0.2286 mL	1.1430 mL	2.2859 mL	11.4296 mL
20 mM	0.1143 mL	0.5715 mL	1.1430 mL	5.7148 mL
50 mM	0.0457 mL	0.2286 mL	0.4572 mL	2.2859 mL
100 mM	0.0229 mL	0.1143 mL	0.2286 mL	1.1430 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc