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GITR/TNFRSF18 Protein, Human, Recombinant (His & Avi), Biotinylated

Catalog No. TMPY-06411
Synonyms: CD357, GITR-D, tumor necrosis factor receptor superfamily, member 18, AITR, GITR

GITR/TNFRSF18 Protein, Human, Recombinant (His & Avi), Biotinylated is expressed in HEK293 mammalian cells with His and Avi tag. The predicted molecular weight is 17.79 kDa and the accession number is Q9Y5U5-3.

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GITR/TNFRSF18 Protein, Human, Recombinant (His & Avi), Biotinylated
Pack Size Availability Price/USD Quantity
20 μg 5 days $ 462.00
100 μg 5 days $ 1,070.00
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Biological Description
Technical Params
Product Properties
References and Literature
Description GITR/TNFRSF18 Protein, Human, Recombinant (His & Avi), Biotinylated is expressed in HEK293 mammalian cells with His and Avi tag. The predicted molecular weight is 17.79 kDa and the accession number is Q9Y5U5-3.
Species Human
Expression System HEK293 Cells
Tag C-His-Avi
Accession Number Q9Y5U5-3
Synonyms CD357, GITR-D, tumor necrosis factor receptor superfamily, member 18, AITR, GITR
Construction The Human TNFRSF18 (NP_683700.1) (Met1-Glu161) was expressed with a C-terminal polyhistidine tag followed by an AVI tag. The expressed protein was biotinylated in vivo by the Biotin-Protein ligase (BirA enzyme) which is co-expressed.
Protein Purity > 95 % as determined by SDS-PAGE.
Molecular Weight 17.79 kDa (predicted)
Endotoxin < 1.0 EU/μg of the protein as determined by the LAL method.
Formulation Lyophilized from a solution filtered through a 0.22 μm filter, containing PBS, pH 7.4. Typically, a mixture containing 5% to 8% trehalose, mannitol, and 0.01% Tween 80 is incorporated as a protective agent before lyophilization.
Reconstitution A Certificate of Analysis (CoA) containing reconstitution instructions is included with the products. Please refer to the CoA for detailed information.
Stability & Storage

It is recommended to store recombinant proteins at -20°C to -80°C for future use. Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at-80℃. For reconstituted protein solutions, the solution can be stored at -20°c to -80'c for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.

Shipping

In general, Lyophilized powders are shipping with blue ice.

Research Background GITR, also known as TNFRSF18(CD357), belongs to the tumor necrosis factor receptor (TNF-R) superfamily. It is the receptor for TNFSF18. GITR plays a key role in dominant immunological self-tolerance maintained by CD25(+)CD4(+) regulatory T cells. GITR may be involved in interactions between activated T-lymphocytes and endothelial cells and in the regulation of T-cell receptor-mediated cell death. GITR and its ligand are important costimulatory molecules in the pathogenesis of autoimmune diseases. It also mediates NF-kappa-B activation via the TRAF2/NIK pathway.Cancer ImmunotherapyCo-stimulatory Immune Checkpoint TargetsImmune CheckpointImmune Checkpoint Detection: ELISA AntibodiesImmune Checkpoint TargetsImmunotherapyTargeted Therapy

References and Literature

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Keywords

GITR/TNFRSF18 Protein, Human, Recombinant (His & Avi), Biotinylated CD357 CD 357 GITR-D tumor necrosis factor receptor superfamily, member 18 CD-357 AITR GITR recombinant recombinant-proteins proteins protein

 

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