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Anti-SOCS3 Polyclonal Antibody
(Synonyms: suppressor of cytokine signaling 3, SSI-3, SSI3, SOCS-3, Cish3, CIS3, ATOD4) Copy Product Info
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Synonyms: suppressor of cytokine signaling 3, SSI-3, SSI3, SOCS-3, Cish3, CIS3, ATOD4
Catalog No. TMAB-01748 Copy Product Info
🥰Excellent
Anti-SOCS3 Polyclonal Antibody is a Rabbit antibody targeting SOCS3. Anti-SOCS3 Polyclonal Antibody can be used in FCM,WB.
Anti-SOCS3 Polyclonal Antibody
| Pack Size | Price | USA Stock | Global Stock | Quantity |
|---|---|---|---|---|
| 50 μL | $222 | 7-10 days | 7-10 days | |
| 100 μL | $373 | 7-10 days | 7-10 days | |
| 200 μL | $527 | 7-10 days | 7-10 days |
For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)
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For research use only—not for human use. No sales to individuals. Use as intended only.
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Product Introduction
Bioactivity
Antigen Details
Chemical Properties
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| Description | Anti-SOCS3 Polyclonal Antibody is a Rabbit antibody targeting SOCS3. Anti-SOCS3 Polyclonal Antibody can be used in FCM,WB. |
| Synonyms | suppressor of cytokine signaling 3, SSI-3, SSI3, SOCS-3, Cish3, CIS3, ATOD4 |
| Ig Type | IgG |
| Reactivity | Human,Mouse,Rat (predicted:Dog,Pig,Cow,Horse,Rabbit,Sheep) |
| Application | |
| Recommended Dose | WB: 1:500-2000; FCM: 1ug/Tes |
| Antibody Type | Polyclonal |
| Host Species | Rabbit |
| Subcellular Localization | Cytoplasm |
| Tissue Specificity | Widely expressed with high expression in heart, placenta, skeletal muscle, peripheral blood leukocytes, fetal and adult lung, and fetal liver and kidney. Lower levels in thymus. |
| Construction | Polyclonal Antibody |
| Purification | Protein A purified |
| Appearance | Liquid |
| Formulation | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| Concentration | 1 mg/mL |
| Research Background | Cytokines signal transduction pathway suppressor of cytokine signaling 3 positive cells in the brain are widely distributed, some of the cytoplasm of neurons, nerve fibers, glial cell line. suppressor of cytokine signaling 3 studies in recent years to prove: vascular endothelial cells also showed immune SOCS 3-positive. |
| Immunogen | KLH conjugated synthetic peptide: human SOCS3 |
| Antigen Species | Human |
| Gene Name | SOCS3 |
| Gene ID | |
| Protein Name | Suppressor of cytokine signaling 3 |
| Uniprot ID | |
| Biology Area | Response to hypoxia,STATs,IL6 Related,Hypoxia,Obesity,Cytoplasmic,Intracellular Molecules |
| Function | SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. SOCS3 is involved in negative regulation of cytokines that signal through the JAK/STAT pathway. Inhibits cytokine signal transduction by binding to tyrosine kinase receptors including gp130, LIF, erythropoietin, insulin, IL12, GCSF and leptin receptors. Binding to JAK2 inhibits its kinase activity. Suppresses fetal liver erythropoiesis. Regulates onset and maintenance of allergic responses mediated by T-helper type 2 cells. Regulates IL-6 signaling in vivo (By similarity). Probable substrate recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Seems to recognize IL6ST (By similarity). |
| Molecular Weight | Theoretical: 25 kDa. Actual: 26 kDa. |
| Stability & Storage | Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| Transport | Shipping with blue ice. |
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